ISSN:
1573-8221
Keywords:
pharmacokinetics
;
antipyrine
;
individual resistance to hypoxia
;
cold stress
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia. High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics under conditions of cold stress.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02447243
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