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  • 1
    Electronic Resource
    Electronic Resource
    Glycaemic responses to commonly ingested breakfasts in children with insulin-dependent diabetes mellitus (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 353-355 
    Details
    ISSN: 1432-1076
    Keywords: Insulin-dependent diabetes ; Children ; Glycaemic index ; Diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The glycaemic response to commonly ingested breakfast with different glycaemic index (cornflakes, white bread, dark rye bread and muesli) was investigated in 14 children with insulin-dependent diabetes mellitus. The blood glucose response after cornflakes was significantly higher than after the other breakfasts, whereas the areas under the blood glucose curve were not statistically different. We observed no difference in blood glucose rise between the other breakfast types. Conclusion Postprandial blood glucose measurements after meals with high glycaemic index may be useful in order to minimize the postprandial rise in blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072101
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: Effect on growth, IGF-I and IGFBP-3 concentrations (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 437-444 
    Details
    ISSN: 1432-1076
    Keywords: Turner syndrome ; Growth hormone ; Anabolic steroids ; IGF-I, IGFBP-3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-nine girls with Ullrich-Turner syndrome (UTS) (median age 9.5 years) were treated with growth hormone (GH) with either 12 or 18 IU/m2 per week for 12 months followed by combination therapy with either oxandrolone (Ox) (0.0625 mg/kg/day po) or low-dose testosterone (T) (5 mg im every 2 weeks). Growth velocity improved significantly after 12 IU/m2 per week (6.4±1.7 cm/year vs 4.0±1.3 cm/year, x±SD,P〈0.001) and 18 IU/m2 per week of GH (6.5±1.3 cm/year vs 4.5±1.4 cm/year,P〈0.001). Ox, but not T was effective in maintaining growth velocity during the 2nd year of therapy (6.9±1.3 vs 5.3±1.5 cm/year). Basal insulin-like growth factor-I (IGF-I) concentrations were in the lower normal range and increased significantly in patients treated with 18 IU/m2 per week (357±180 ng/ml vs 160±84 ng/ml) and 12 IU/m2 per week (273±121 ng/ml vs 140±77 ng/ml). IGF-I concentrations increased further after addition of Ox (533±124 ng/ml,P〈0.001) or T (458±158,P〈0.05). IGFBP-3 concentrations were in the upper normal range before therapy and increased only moderately in both GH dosage groups. However, IGF binding protein-3 (IGFBP-3) concentrations were not affected by additional Ox or T treatment. Conclusions 1. Conventional GH doses are effective in increasing growth velocity in UTS, especially, when combined with Ox. This additive effect is not evident when GH is combined with low dose T. 2. Changes in growth velocity are accompanied by an increase of the IGF-I/IGFBP-3 ratio. 3. Ox obviously acts by increasing IGF-I levels independent of the GH status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02029351
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: effect on growth, IGF-I and IGFBP-3 concentrations (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 437-444 
    Details
    ISSN: 1432-1076
    Keywords: Key words Turner syndrome ; Growth hormone ; Anabolic steroids ; IGF-I ; IGFBP-3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-nine girls with Ullrich-Turner syndrome (UTS) (median age 9.5 years) were treated with growth hormone (GH) with either 12 or 18 IU/m2 per week for 12 months followed by combination therapy with either oxandrolone (Ox) (0.0625 mg/kg/day po) or low-dose testosterone (T) (5 mg im every 2 weeks). Growth velocity improved significantly after 12 IU/m2 per week (6.4 ± 1.7 cm/year vs 4.0 ± 1.3 cm/year, x ± SD, P 〈 0.001) and 18 IU/m2 per week of GH (6.5 ± 1.3 cm/year vs 4.5 ± 1.4 cm/year, P 〈 0.001). Ox, but not T was effective in maintaining growth velocity during the 2nd year of therapy (6.9 ± 1.3 vs 5.3 ± 1.5 cm/year). Basal insulin-like growth factor-I (IGF-I) concentrations were in the lower normal range and increased significantly in patients treated with 18 IU/m2 per week (357 ± 180 ng/ml vs 160 ± 84 ng/ml) and 12 IU/m2 per week (273 ± 121 ng/ml vs 140 ± 77 ng/ml). IGF-I concentrations increased further after addition of Ox (533 ± 124 ng/ml, P 〈 0.001) or T (458 ± 158, P 〈 0.05). IGFBP-3 concentrations were in the upper normal range before therapy and increased only moderately in both GH dosage groups. However, IGF binding protein-3 (IGFBP-3) concentrations were not affected by additional Ox or T treatment. Conclusions 1. Conventional GH doses are effective in increasing growth velocity in UTS, especially, when combined with Ox. This additive effect is not evident when GH is combined with low dose T. 2. Changes in growth velocity are accompanied by an increase of the IGF-I/IGFBP-3 ratio. 3. Ox obviously acts by increasing IGF-I levels independent of the GH status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02029351
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Glycaemic responses to commonly ingested breakfasts in children with insulin-dependent diabetes mellitus (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 353-355 
    Details
    ISSN: 1432-1076
    Keywords: Key words Insulin-dependent ; diabetes ; Children ; Glycaemic ; index ; Diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The glycaemic response to commonly ingested breakfast with different glycaemic index (cornflakes, white bread, dark rye bread and muesli) was investigated in 14 children with insulin-dependent diabetes mellitus. The blood glucose response after cornflakes was significantly higher than after the other breakfasts, whereas the areas under the blood glucose curve were not statistically different. We observed no difference in blood glucose rise between the other breakfast types. Conclusion Postprandial blood glucose measurements after meals with high glycaemic index may be useful in order to minimize the postprandial rise in blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050302
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The influence of growth hormone monotherapy and growth hormone in combination with oxandrolone or testosterone on thyroxid hormone parameters and thyrxine binding globulin in patients with Ullrich- Turner syndrome (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 99-103 
    Details
    ISSN: 1432-1076
    Keywords: Key words Ullrich-Turner syndrome  ;  Growth hormone therapy  ;  Thyroid hormone regulation  ;  Insulin-like growth factor I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Administration of human growth hormone (GH) has yielded conflicting results concerning its role on thyroid function in patients with Ullrich-Turner syndrome. Therefore, we investigated the course of thyroid hormone parameters and thyroxin binding globulin in relation to GH therapy, IGF-I and additional oxandrolone-(Ox) or testosterone (T) treatment in 20 patients with Ullrich-Turner syndrome. During the 1st year the patients received only GH. There was no change in T4, fT4, and TSH levels, T3 increased significantly (P 〈  0.01) after 6 and 12 months, resulting in a higher T3/T4 ratio. TBG (P 〈 0.05) and IGF-I (P 〈 0.01) increased after 6 months and remained elevated at 12 months. A significant positive correlation was found between the change of T4 and TBG after 6 months (r = 0.47, P 〈 0.05) and after 12 months (r = 0.69, P 〈 0.005). Thirteen patients were further investigated after addition of an anabolic compound; 7 received Ox (0.0625 mg/kg/day po) and 6 low dose T (5 mg i.m. every 14 days). Chronological age was comparable in these groups (10.7 ±  2.7 vs 10.7  ± 3.6 years). After 6 months of combination therapy with Ox, T4, T3 and TSH decreased. As T4 and T3 showed a parallel decrease the T3/T4 ratio remained elevated. TBG declined after 6 and 12 months (P 〈 0.05), while IGF-I showed a further increment (P 〈 0.05). There was no correlation between the changes in T4 and IGF-I, TSH and TBG, respectively. In the T-treated group only IGF-I increased (P 〈 0.05) to the same extent as in the Ox-treated patients, whereas the thyroid parameters did not change. Conclusion The observed changes in thyroid hormone and TBG levels in the Ox group were not mediated by GH or IGF-I. The Ox-induced TBG decrease might be linked to altered pancreatic functions regulating carbo-hydrate metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050563
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  • 6
    Electronic Resource
    Electronic Resource
    Short- and long-term (final height) data in children with normal variant short stature treated with growth hormone (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 680-683 
    Details
    ISSN: 1432-1076
    Keywords: Key words Growth hormone therapy ; Normal variant short stature ; Height prediction ; Target height
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventeen children with normal variant short stature and a predicted height below −2 SDS were treated with growth hormone (GH) six times a week for a period of 5 years. Patients were randomly selected to receive three different doses of GH, group 1 (n=6) 3␣IU/m2 per day, group 2 (n=6) 4.5 IU/m2 per day and group 3 (n=5) 3 IU/m2 per day in the 1st year and 4.5␣IU/m2 per day thereafter. There was a significant increase in height after 1 and 2 years for all patients and for all subgroups. However, this increase was not dependent on GH dose. The decrease in height velocity during the 2nd year was not prevented by the increase of GH dose in group 3. The change of predicted height after 2 years was +0.75 SDS (according to Tanner Whitehouse). Fourteen children have been treated for 4␣years and 8 children for 5 years without a further change in height prediction. Nine patients have reached final height which was 2.4 cm (+0.41 SDS) above pretreatment height prediction. Final height was nearly identical to predicted height after 1 year of therapy. Conclusion An increment in height prediction was observed during the first 2 years of GH treatment and maintained thereafter. However, there was only a minor increase in final height over predicted height which does not justify the general use of GH in children with normal variant short stature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050689
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Risk factors for type I diabetes mellitus in children in Austria (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 362-366 
    Details
    ISSN: 1432-1076
    Keywords: Key words Type 1 diabetes ; Children ; Risk factors ; Case control ; Environmental
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate environmental risk factors in the development of type 1 diabetes mellitus in a population-based case-control study. Parents of all patients with manifestation of type 1 diabetes between 1989 and 1994 in Vienna were asked to complete a questionnaire (n = 114). Control children (n = 495), matched for age and sex, were randomly recruited from all schools in Vienna. Fathers of diabetic children were significantly older at the time their children were born than fathers of control children (P = 0.015). Children with diabetes were more likely to be second- or third-born children (P 〈 0.05) and fewer went to kindergarten than the control group children (P = 0.007). No significant difference in duration of gestation, percentage of delivery by caesarean section, birth weight or length was found. Neonatal jaundice was more often observed in the patient group (P = 0.038). Breast feeding was reported by 82.7% of mothers of diabetic children and by 81% of mothers of control children, and the duration of breast feeding was longer in patients than in controls (n.s.). Conclusion In our study, the development of type 1 diabetes mellitus was associated with higher paternal age and neonatal jaundice. No correlation could be found with dietary intake of cow's milk products in early infancy, vaccination and other environmental factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051092
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    Paper (German National Licenses)
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