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  • 1
    Electronic Resource
    Electronic Resource
    Sympathetic Sprouting: Time Course of Changes of Noradrenergic, Cholinergic, and Serotonergic Markers in the Denervated Rat Hippocampus (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: As a first step for experiments investigating the presynaptic characteristics of sympathetic fibers grown into the denervated hippocampus, we studied the time course of changes of neurochemical markers in the rat hippocampus, subsequent to aspiration lesions of the fimbria-fornix and the overlying callosal and cortical structures. At various postsurgical delays (1, 2, 8, 24, and 40 weeks), the activity of choline acetyltransferase, the high-affinity synaptosomal uptake of choline and noradrenaline, and the concentrations of noradrenaline, serotonin, and 5-hydroxyindoleacetic acid were measured in a dorsal, an intermediate, and a ventral part of the hippocampus. Levels of all markers were significantly reduced shortly (1–2 weeks) after the lesions. However, whereas the cholinergic (choline uptake and choline acetyltransferase activity) and the serotonergic (concentrations of serotonin and 5-hydroxyindoleacetic acid) markers remained significantly reduced for up to 40 weeks, both noradrenergic markers recovered to near-normal (noradrenaline uptake) or even supranormal (noradrenaline concentration) levels, although with clear-cut differences in the time course and the regional characteristics. The noradrenaline content reached control levels already 8 weeks after lesion surgery and was about two to three times higher 40 weeks later, with the most dramatic effects in the ventral hippocampus. In contrast, high-affinity noradrenaline uptake reached control values only 24 weeks after lesion and exceeded them only in the ventral hippocampus 40 weeks after surgery. It is concluded (a) that hippocampal noradrenaline concentration is a more sensitive marker for sympathetic sprouting than high-affinity noradrenaline uptake and (b) that functional in vitro studies on hippocampal sympathetic ingrowth appear to fit optimal conditions in the ventral hippocampus at a delay of at least 40 weeks after surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65010329.x
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  • 2
    Electronic Resource
    Electronic Resource
    Einfluß von frühem frontoorbitalem Advancement auf das Wachstum von Stirnhöhle und Supraorbitalregion (1998)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. S41 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Kraniosynostose ; Frontoorbitales Advancement ; Wachstumsstörungen der Stirnhöhle und Supraorbitalregion ; Key words Craniosynostosis ; Fronto-orbital advancement ; Disturbance of growth in the frontal region
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 12 patients with craniosynostosis the influence of early fronto-orbital advancement on the growth of the frontal sinus and supraorbital region was examined. A follow-up examination at the age of 8 years showed a lack of pneumatisation of about 50%. However, there was no correlation between this score and the external contour. The frontal sinus has no dominant influence on the growth of the supraorbital region. In 9 out 12 of cases the very early operation time did not lead to disturbances of growth. A further follow-up examination of the patients after termination of growth at the age of 16 is planned.
    Notes: Zusammenfassung Bei 12 Patienten mit Kraniosynostosen wurde der Einfluß eines frühen frontoorbitalen Advancements auf das Wachstum von Stirnhöhle und Supraorbitalregion untersucht. Dabei zeigte sich bei einer Untersuchung im 8. Lebensjahr eine Verminderung der Pneumatisation um 50%. Dieser Wert korrelierte jedoch nicht mit der äußeren Kontur. Der Stirnhöhle kann kein dominierender Einfluß auf das Wachstum der Supraorbitalregion zugeschrieben werden. Der sehr frühe Operationszeitpunkt führte in 9 von 12 Fällen nicht zu Wachstumsstörungen. Eine weitere Untersuchung des Patientenkollektivs mit 16 Jahren nach vollständigem Abschluß des Wachstums wäre wünschenswert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014477
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear levels in228Th populated in the decay of228Pa (1995)
    Springer
    The European physical journal 352 (1995), S. 47-67 
    Details
    ISSN: 1434-601X
    Keywords: 23.20 ; 25.40 ; 27.90.+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The electron-capture decay of228Pa to levels in228Th has been studied using mass-separated sources and high-resolutionγ-ray and conversion-electron spectroscopy. A level at 979.5 keV is assigned as 2+ member of a second excited Kπ=0+ band, with the 0+ band head at 938.6 keV. The 2+ and 3+ members of a second excited Kπ=2+ band at 1153.5 and 1200.5 keV, which decay by strongE0 transitions to the 969 keVγ-vibrational band, are confirmed. In addition we tentatively propose a Kπ=1+ band at 944 keV. The Kπ=0−, 1− and 2− members of the octupole quadruplet are confirmed, and theγ decay of these levels is analysed in an approach, in which the mixing of the octupole bands by the Coriolis interaction is taken into account. It is suggested that octupole correlations might be important for theE1 transition moments. A total of 29 levels is observed between ∼1.4 and ∼2.0 MeV, for which the nuclear structure, and the possible assignment to rotational bands, is unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292760
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  • 4
    Electronic Resource
    Electronic Resource
    Behavioural and neurochemical effects of superior cervical ganglionectomy in rats with septo-hippocampal lesions (1995)
    Springer
    Experimental brain research 102 (1995), S. 429-444 
    Details
    ISSN: 1432-1106
    Keywords: Fimbria-fornix lesion ; Hippocampus ; Radial-arm maze ; Spatial memory ; Sympathetic sprouting ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This longitudinal study, extending over 12 months, assessed the behavioural and biochemical effects of hippocampal sympathetic ingrowth (HSI) into the partially denervated hippocampus. Male Long-Evans rats received fimbria-fornix lesions (FIFO) or sham operations at 90 days of age. At the same time half of the rats from each group sustained bilateral ablation of the superior cervical ganglia (SCGX). A battery of behavioural tests, measuring spontaneous alternation, activity in the open field and home cage, and radial-maze performance, were employed, starting after one very short (16 days) and one extended (216 days) postoperative delay. Neurochemical analyses measuring choline acetyltransferase (ChAT) activity, high-affinity choline (HACU) and noradrenaline uptake by hippocampal synaptosomes (HANU), hippocampal noradrenaline ([NA]), serotonin ([5-HT]) and 5-hydroxyindoleacetic acid ([5-HIAA]) concentrations were carried out in a dorsal, a “middle” and a ventral region of the hippocampus. Lesion of the FIFO induced a significant and enduring deficit in radial-maze performance, in addition to a persistent locomotor hyperactivity. ChAT and HACU were significantly depleted in all three regions of the hippocampus at 12 months, and these deficits were negatively correlated with maze performance. SCGX in the presence of the FIFO lesion significantly reduced [NA] in the middle region of the hippocampus, as compared to SCGX rats, and contributed to a restoration of lesion-induced depletions in [5-HT] and [5-HIAA] in the middle and ventral hippocampal regions, whilst failing to elicit any behavioural changes at either time point. It is concluded that if lesion-induced HSI indeed occurred, as is suggested by neurochemical evidence, it had no effect upon the observed behavioural deficits elicited by transection of the FIFO in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230648
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular/cell engineering approach to autocrine ligand control of cell function (1995)
    Springer
    Annals of biomedical engineering 23 (1995), S. 208-215 
    Details
    ISSN: 1573-9686
    Keywords: Receptors ; Cell proliferation ; Cancer therapy ; Tissue engineering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Tissue engineering, along with other modern celland tissue-based health care technologies, depends on successful regulation of cell function by molecular means, including pharmacological agents, materials, and genetics. This regulation is generally mediated by cell receptor/ligand interactions providing primary targets for molecular intervention. While regulatory ligands may often be exogenous in nature, in the categories of endocrine and paracrine hormone systems, they are being increasingly appreciated as crucial in local control of cell and tissue function. Improvements in design of health care technologies involving autocrine ligand interactions with cell receptors should benefit from increased qualitative and quantitative understanding of the kinetic and transport processes governing these interactions. In this symposium paper we offer a concise overview of our recent efforts combining molecular cell biology and engineering approaches to increase the understanding of how molecular and cellular parameters may be manipulated for improved control of cell and tissue function regulated by autocrine ligands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00000002
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