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  • 1990-1994  (5)
  • 1985-1989  (1)
  • 1965-1969  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Reconstruction of symmetry-related molecules from protein data bank (PDB) files (1994)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 27 (1994), S. 1006-1009 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Many natural proteins are active as multimers. Crystallographic protein databases, however, generally store only part of the native multimer, the asymmetric unit, along with symmetry information. As a result of inaccuracies in the data, it is not always possible to reconstruct the native multimer. Here, a set of methods is presented that are designed to cope with inconsistencies in symmetry information. Applications include the validation of Protein Data Bank entries and the automatic generation of symmetry contacts for inspection and analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889894007764
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  • 2
    Electronic Resource
    Electronic Resource
    Quality control of protein models: directional atomic contact analysis (1993)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 26 (1993), S. 47-60 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Branden & Jones state, in Nature: `Protein crystallography is an exacting trade, and the results may contain errors that are difficult to identify. It is the crystallographer's responsibility to make sure that incorrect protein structures do not reach the literature.' [Branden & Jones. (1990). Nature (London), 343, 687–689.] One of several available methods of checking structures for correctness is the evaluation of atomic contacts. From an initial hypothesis that atom-atom interactions are the primary determinant of protein folding, any protein model can be tested for proper packing by the calculation of a contact quality index. The index is a measure of the agreement between the distributions of atoms around each residue fragment in the model and equivalent distributions derived from the database of known structures solved at high resolution. The better the agreement, the higher the contact quality index. This empirical test, which is independent of X-ray data, is applied to a series of successively refined crystal structures. In all cases, the model known or expected to be better (the one with the lower R-factor) has a better contact quality index, indicating that this type of contact analysis can be used as an independent quality criterion during crystallographic refinement. Modelled proteins and predicted mutant structures can also be evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889892008240
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  • 3
    Electronic Resource
    Electronic Resource
    Eitrige Vulvovaginitis bei einem neugeborenen Mädchen als seltene Form einer Trichomonas vaginalis-Infektion und ihre Behandlung (1967)
    Springer
    European journal of pediatrics 98 (1967), S. 364-369 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In vulvovaginitis of the child the percentage of infections by Trichomonas vaginalis is much smaller than in adult patients. A case of trichomonas — colpitis in a newborn girl is reported, presumably acquired paranatally. After a review of the organisms causing vulvovaginitis the developmental changes of the vagina are discussed. In addition to epidemiologic factors these seem to be important for the rare occurrence of trichomonas-colpitis in childhood. Finally the problems of therapy are discussed: Clont® (Metronidazol) is effective and well tolerated in infants and children.
    Notes: Zusammenfassung Der durch Trichomonadeninfektion bedingte Anteil ist bei kindlichen Vulvovaginitiden viel geringer als im gebärfähigen Alter. Es wird der Fall einer Trichomonadenkolpitis bei einem neugeborenen Mädchen dargestellt, bei dem eine Infektion unter der Geburt anzunehemen ist. Nach Besprechung der Erreger werden die entwicklungsbedinten Änderungen von Scheidenschleimhaut und-milieu behandelt. Neben epidemiologischen Gesichtspunkten scheinen diese für das seltenere Vorkommen der Trichomonadenkolpitis im Kindesalter wichtig zu sein. Zuletzt wird auf Fragen der Therapie eingegangen; mit Clont® steht ein auch im Säuglings-und Kindesalter gut wirksames und verträgliches Medikament zur Verfügung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00523647
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  • 4
    Electronic Resource
    Electronic Resource
    Die Frühtetanie des jungen Säuglings als Ausdruck eines transitorischen, idiopathischen Hypoparathyreoidismus (1967)
    Springer
    European journal of pediatrics 99 (1967), S. 211-223 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From neonatal tetany of the first days as syndrome of adaptation a form of tetany of early infancy can be distinguished. It usually becomes manifest between the 1st and 4th week showing convulsions. Three cases of early tetany are reported, they are diagnosed as transitory hypoparathyroidism from the results of serum-chemical examinations, positive parathormonetests and clinical course. After showing the differential diagnosis of early tetany the problems of calcium homoeostasis and the regulation by parathormone as well as diagnostic problems of hypoparathyroidism are discussed. The concepts of pathogenesis of early tetany are shown. Finally the data of therapy, that was applied in our cases, are given: 3–5 weeks, clinically and serum-chemically controlled, therapy with Vitamin D (2000–30000 units daily), which is reduced and discontinued during the next 3–4 weeks.
    Notes: Zusammenfassung Von der Neugeborenentetanie als Adaptationssyndrom der ersten Lebenstage ist die meist zwischen der 1. und 4. Woche sich mit Krampfanfällen manifestierende Frühtetanie des jungen Säuglings zu unterscheiden. Es wird über drei Kinder mit Frühtetanie berichtet, bei denen nach serumchemischen Befunden, positiven Parathormontesten und klinischem Verlauf ein transitorischer Hypoparathyreoidismus anzunehmen ist. Nach Aufzeigen der Differentialdiagnose der Frühtetanie wird auf Probleme der Regulation des Calciumstoffwechsels und der Klinik und Diagnostik des Hypoparathyreoidismus eingegangen. Nach einer Besprechung der pathogenetischen Vorstellungen über die Frühtetanie wird die in den Fällen von transitorischem Hypoparathyreoidismus angewendete Therapie dargestellt: drei- bis fünfwöchige Gabe von täglich 20000 bis 30000 E Vitamin D unter laufender klinischer und serumchemischer Kontrolle; innerhalb von 3–4 Wochen dann zunächst Reduktion auf Dosen der laufenden Rachitisprophylaxe und späteres Absetzen des Vitamin D bei weiterer ambulanter Kontrolle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00522703
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  • 5
    Electronic Resource
    Electronic Resource
    A human cDNA coding for the Leydig insulin-like peptide (Ley I-L) (1994)
    Springer
    Human genetics 〈Berlin〉 94 (1994), S. 91-94 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract cDNA clones for the human Leydig insulin-like peptide (Ley I-L) have been isolated and characterized. The nucleotide sequence of the 743-bp cDNA includes an incomplete 7-bp 5′-noncoding region, an open reading frame of 393 bp, and a 343-bp 3′-noncoding region. By primer extension analysis, the transcription start site was determined as being 14-bp upstream of the translation start site. The underlying gene is expressed in the testis but not in other organs. From the cDNA sequence, it can be deduced that the Ley I-L protein is synthesized as a 131-amino-acid (aa) preproprotein and that it contains a 24-aa signal peptide. Comparison of the pro Ley I-L protein with members of the insulin-like hormone superfamily predicts that the biologically active hormone, after proteolytic processing of the C peptide, consists of a 31-aa long B chain and a 26-aa long A chain, and that it has a molecular weight of 6.25 kDa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272850
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  • 6
    Electronic Resource
    Electronic Resource
    Methämoglobinvergiftung nach Spinatgenuß bei einem zweijährigen Knaben (1967)
    Springer
    European journal of pediatrics 98 (1967), S. 222-226 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A case of nitrite-poisoning after ingestion of spinach in a 2 year old boy is reported. He developed severe methaemoglobinaemia of 53%. In 100 g of the spinach, which had been stored in the refrigerator after preparation for 3 days, 150 mg of nitrite-ion was found. It had been fed in unusually great amount because of obstipation. A congenital methaemoglobinaemia (haemoglobin-anomaly or deficiency of reducing enzymes) was excluded. After injection of Thionin there was quick recovery, the level of methaemoglobin got normal.
    Notes: Zusammenfassung Es wird über eine Nitritvergiftung nach Genuß von Spinat berichtet, die bei einem zweijährigen Knaben auftrat. Es kam zu einer schweren Methämoglobinämie von 53%. Der nach Zubereitung 3 Tage im Eisschrank aufbewahrte Spinat wies in 100 g 150 mg Nitrition auf. Das Gemüse war wegen Obstipation in ungewöhnlich großer Menge gefüttert worden. Eine angeborene Methämoglobinämie (Hämoglobinanomalie und Reduktaseinsuffizienz) wurde ausgeschlossen. Nach Thionininjektion kam es zu rascher Besserung des klinischen Bildes und Normalisierung des Methämoglobinspiegels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00518039
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  • 7
    Electronic Resource
    Electronic Resource
    Über das Auftreten oxacillinresistenter Staphylokokken auf einer Frühgeborenenstation (1969)
    Springer
    European journal of pediatrics 106 (1969), S. 163-170 
    Details
    ISSN: 1432-1076
    Keywords: Oxacillinresistenz ; Staphylokokken-Hospitalismus ; Frühgeboreneninfektionen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über das Auftreten von 14 oxacillinresistenten Staphylococcus aureus-Stämmen, in einem Fall bei einer Osteomyelitis isoliert, berichtet, die innerhalb von 3 Monaten auf einer Frühgeborenenstation gefunden wurden. In den vorangegangenen Jahren wie auch bei Umgebungsuntersuchungen im folgenden Halbjahr war Oxacillinresistenz bei Staphylococcus aureus auf dieser Station nicht feststellbar. Das Phagspektrum der Stämme war ähnlich, jedoch nicht identisch; Phaggruppe III war vorherrschend. Probleme der Oxacillinresistenz, insbesondere die Frage der Kreuzresistenz in ihrer Ausprägung für die einzelnen halbsynthetischen Penicilline und Cephalosporine und die klinische Bedeutung werden besprochen. Zuletzt werden die Folgerungen für die Therapie erörtert.
    Notes: Summary The isolation of 14 Oxacillin-resistant strains of Staph. aureus is reported. They were found over a period of 3 months on a ward for premature infants. One strain was isolated from a case of osteomyelitis. During the preceeding years as well as during the 6 months following the isolation of these strains Oxacillin-resistant Staph. aureus had not been demonstrated in environmental investigations on this ward. The phage pattern of the strains was similar, but not identical. Phage group III was predominant. The problems of Oxacillin resistance, particularly the cross-resistance to the various semi-synthetic penicillins and cephalosporins, and their clinical implications are discussed. Finally, the consequences on the therapy, with special reference to infections in premature infants, are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00476254
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  • 8
    Electronic Resource
    Electronic Resource
    Variability in clinical expression of Menkes syndrome (1988)
    Springer
    European journal of pediatrics 148 (1988), S. 132-135 
    Details
    ISSN: 1432-1076
    Keywords: Menkes syndrome ; Genetic heterogeneity ; Copper therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six patients with Menkes syndrome are described, who differ from patients with the classical form of Menkes syndrome because of their longer survival; some of them also exhibited a milder manifestation of symptoms. Based on the present data and a summary of seven case reports describing Menkes patients with long survival, it may be possible to divide these patients into two subgroups:one group of severely affected patients with long survival and another group of very mildly affected patients with late onset of symptoms. Perhaps only the latter represents a true subgroup of Menkes syndrome. The possible benefits of copper therapy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445920
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  • 9
    Electronic Resource
    Electronic Resource
    The structure of ColE1 rop in solution (1991)
    Springer
    Journal of biomolecular NMR 1 (1991), S. 71-82 
    Details
    ISSN: 1573-5001
    Keywords: rop ; Protein conformation ; 2D NMR ; Molecular dynamics ; Repressor proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The structure of the ColE1 repressor of primer (rop) protein in solution was determined from the proton nuclear magnetic resonance data by a combined use of distance geometry and restrained molecular dynamics calculations. A set of structures was determined with low internal energy and virtually no violations of the experimental distance restraints. Rop forms homodimers: Two helical hairpins are arranged as an antiparallel four helix bundle with a left-handed rope-like twist of the helix axes and with left-handed bundle topology. The very compact packing of the side chains in the helix interfaces of the rop coiled-coil structure may well account for its high stability. Overall, the solution structure is highly similar to the recently determined X-ray structure (Banner, D.W., Kokkinidis, M. and Tsernoglou, D. (1987)J. Mol. Biol.,196, 657–675), although there are minor differences in regions where packing forces appear to influence the crystal structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01874570
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  • 10
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of rhodanese (1990)
    Springer
    Journal of molecular histology 22 (1990), S. 197-200 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The role of rhodanese in the detoxication of acute cyanide exposure is controversial. The debate involves questions of the availability of rhodanese to cyanide in the peripheral circulation. Blood-borne cyanide will distribute to the brain and may induce lesions or even death. The present study addresses the dispute by determining the distribution of rhodanese in tissues considered to have the highest rhodanese activity and thought to serve as major detoxication sites. The results indicate that rhodanese levels are highest in (1) hepatocytes that are in close proximity to the blood supply of the liver (2) epithelial cells surrounding the bronchioles (a major entry route for gaseous cyanide) and (3) proximal tubule cells of the kidney (serving to facilitate cyanide detoxication and elimination as thiocyanate). Rhodanese activity in the brain is low compared with liver and kidney (Mimoriet al., 1984; Drawbaugh & Marrs, 1987); the brain is not considered to be a major site of cyanide detoxication. The brain, however, is the target for cyanide toxicity. In this study our goal was also to differentiate the distribution of rhodanese in an area of the brain. We found that the enzyme level is highest in fibrous astrocytes of the white matter. Cyanide-induced brain lesions may thus occur in areas of the brain lacking sufficient sites for detoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02386005
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