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  • 1990-1994  (2)
  • 1985-1989  (1)
  • 1920-1924
  • Amino acids  (2)
  • Neurofilaments  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Amino acids and the kidney (1991)
    Springer
    Amino acids 1 (1991), S. 183-192 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Kidney ; Nutrition ; Phenylalanine ; Tyrosine ; Uraemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney has an important role in the metabolism of amino acids and control of plasma concentrations. Reabsorption by the tubules recovers about 70g/day of amino acids, derived from both the diet and metabolism in other tissues. Amino acids regulate haemodynamics and proteolysis and maintain integrity of the kidney. Abnormal plasma and muscle amino acid profiles in chronic renal failure (i.e. low essentials and tyrosine with high nonessentials) first indicated malnutrition, which can be partially corrected by supplementation. The loss of effective kidney tissue and uraemia, in addition to nutrition, have been considered in studies of phenylalanine hydroxylation used to investigate low tyrosine. Investigations in normal kidney have shown that glutamine uptake maintains acid-base homeostasis, glycine and citrulline are removed, and serine and arginine are released into the circulation. These metabolic processes are impaired in chronic renal failure. Uraemia affects most tissues and causes malnutrition, whilst acidosis activates catabolism of amino acids and proteins in muscle. Hyperinsulinaemia probably depresses plasma branchedchain amino acids and particularly valine. These abnormalities are less likely to respond to dietary supplementation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806915
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses (1994)
    Springer
    Amino acids 6 (1994), S. 283-293 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Chronic renal failure ; Plasma ; Urine ; D-amino acids ; CAPD ; D-Tyrosine ; D-Phenylalanine ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Total D-amino acids were measured in plasma for 20 non-dialysed patients (creatinine clearance 〈 12 ml/minute), 20 on CAPD, 20 on haemodialysis and 20 normals. Plasma D-tyrosine and D-phenylalanine were measured in 8 of each group by HPLC. Total D-amino acids, D-tyrosine and D-phenylalanine were significantly greater for patients than normals. D-amino acids and D-tyrosine correlated with creatinine and were decreased during HD. During dialysis, the mean losses for D-tyrosine and D-phenylalanine were similar, about 0.2 mg/CAPD exchange and 3 mg/4 hour haemodialysis (i.e. 2% of the total amino acid, as in plasma). Clearance was unaffected by stereochemical configuration. Urinary losses/24 hour in the non-dialysed patients were 0.35 mg D-tyrosine and 0.25 mg D-phenylalanine. Clearance for D-phenylalanine was greater than for the L-enantiomer. Increases in D-amino acids in renal failure are probably due to depletion of D-amino acid oxidase, but may be enhanced by a D-amino acid rich diet, peptide antibiotics and D-amino acid oxidase inhibiting drugs and metabolites. Possible toxic effects need further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00813748
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Neuronal intranuclear hyaline inclusion disease in a nine year old (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 327-332 
    Details
    ISSN: 1432-0533
    Keywords: Neurons ; Hyaline ; Inclusions ; Neurofilaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen previous cases have been reported as neuronal intranuclear hyaline inclusion disease. The majority of patients have presented with movement disorders at less than 12 years of age followed by a progressive worsening of symptoms and, frequently, loss of cognitive function. Death has usually occurred by the second or third decade. Three have presented in the fifth through seventh decade with either movement disorders or dementia. These cases have been linked by the presence of eosinophilic neuronal intranuclear inclusions diffusely within the CNS and in peripheral ganglion cells. The patient in this case report also presented with a rapidly progressive movement disorder and at autopsy showed the characteristic intranuclear inclusions. Investigation of these inclusions did not reveal shared epitopes with neurofilaments or other intermediate filaments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686092
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    Paper (German National Licenses)
    Fulltext
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