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  • 1
    Electronic Resource
    Electronic Resource
    The First Data from the MACHO Experiment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 688 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb43945.x
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  • 2
    Electronic Resource
    Electronic Resource
    Hypersensitivity pneumonitis induced by Penicillium expansum in a home environment (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An episode of fever, cough, shortness of breath and leucocytosis developed in a 31-year-old atopic housewife from mould exposure in her home environment is evaluated. A chest radiograph revealed diffuse tiny nodular infiltrations in both whole lung fields. Spirometry revealed a severe restrictive type of ventilation impairment. Bronchoalveolar lavage (BAL) showed an increased lymphocyte count with reversed CD4 +/CD8 + ratio and transbronchial lung biopsy showed markedly increased lymphocytic infiltration in alveolar septa. Fungal cultures in the air of her home were positive for Penicillium expansum and other fungi. Double immunodiffusion test with the patient's serum showed two precipitin bands to P. expansum antigens. Her symptoms, abnormal findings of radiograph, and spirometric abnormalities disappeared after 2 months' avoidance. The serum precipitin disappeared after 1 month's avoidance. This study indicates that the patient had hypersensitivity pneumonitis (HP) on exposure to P. expansum in her home environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00251.x
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  • 3
    Electronic Resource
    Electronic Resource
    Occupational asthma caused by chromium (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. We report four cases of occupational asthma caused by chromium salts, three of whom showed dual and one isolated early asthmatic responses on specific chromium bronchoprovocation test (BPT). All of them were ex–smokers. Two showed positive skin–prick tests to 10mg/ml of Cr2(SO4)3, but negative results on patch testing. The remaining two showed positive results on patch testing with Cr2(SO4)3. Three had airway hyperresponsiveness to methacholine on initial examination. Although initial methacholine airway challenge testing showed a negative result in the remaining patient, airway hyperresponsiveness developed transiently 24 h after an isolated immediate asthmatic reaction induced by chromium. Three patients were reassessed after complete avoidance of chromium. Two subjects showed marked improvement of their symptoms with significant increases of PC20 methacholine. We conclude that chromium induces occupational asthma in exposed workers. Further investigations are needed to clarify the pathogenetic mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00972.x
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  • 4
    Electronic Resource
    Electronic Resource
    Occupational asthma caused by two herb materials, Dioscorea batatas and Pinellia ternata (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. There have been very few cases of occupational allergies caused by herb materials. In this paper, we report a case of occupational asthma and rhinitis caused by two herb materials. Dioscorea batatas and Pinellia ternata which are known as Sanyak and Banha respectively. The patient had strong positive responses to grass pollens and cat fur, as well as to Sanyak and Banha extracts on skin-prick tests. Bronchoprovocation tests showed a dual asthmatic response to Sanyak whereas only an early asthmatic response to Banha. Serum specific IgE and IgG4 antibodies to Sanyak were detected by enzyme-linked immunosorbent assay (ELISA) but there was no specific IgE antibody binding to Banha. In order to further characterize the allergenie component of these extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were also performed. Three IgE binding components (29000, 57000, 63000 Da) were detected within the Sanyak extracts, but no IgE-binding component was noted within the Banha extracts. It is suggested that Sanyak can induce IgE-mediated bronchoconstriction in an exposed worker. Further studies are needed to investigate the pathogenetic mechanism triggered by Banha.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00955.x
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  • 5
    Electronic Resource
    Electronic Resource
    Heterogeneity of IgE antibody response to reactive dye in sera from four different sensitized workers (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied RAST and RAST inhibition tests to black GR, the most frequent sensitizer among several reactive dyes in our previous study, in order to evaluate the specificity of IgE antibodies to hapten or new antigenic determinants and the crossreactivity between two reactive dyes, black GR and orange 3R, in sera from four different sensitized workers. RAST inhibition studies with black GR-human serum albumin (HSA) conjugate discs demonstrated that black GR-HSA conjugates were the most effective inhibitors. Orange 3R-HSA conjugates, unconjugated forms of black GR and orange 3R were weak inhibitors in two patients and non-inhibitory in one patient, whereas they caused strong dose-dependent inhibitions in one patient. These results suggested that the IgE response to black GR-HSA conjugates might be heterogenous and the cross-reactivity between two reactive dyes differed from one patient to another.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00176.x
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  • 6
    Electronic Resource
    Electronic Resource
    The significance of specific IgG and IgG4 antibodies to a reactive dye in exposed workers (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To evaluate the significance of specific IgG and specific IgG4 in the development of work-related respiratory symptoms, specific IgG and specific IgG4 to Black GR-human serum albumin (HSA) conjugate were measured by ELISA in 309 dye-exposed workers and 63 unexposed patients as negative controls. A survey revealed that 78 (25.2%) had work-related lower respiratory symptoms with or without nasal, skin or eye symptoms. Specific IgG and specific IgG4 were detected in 23% and 14% of the exposed workers, respectively. The prevalence of specific IgG and specific IgG4 was significantly higher in smokers and workers with specific IgE or those with lower respiratory symptoms (P 〈 0.05), but was not associated with work station, duration of dye exposure or atopy. These results suggested that the existence of specific IgG to Black GR HSA might represent a response to Black GR exposure and be closely related with work-related respiratory symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01668.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of exogenous and endogenous histamine on the respiratory system (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 991-996 
    Details
    ISSN: 1432-1440
    Keywords: Histamine ; Obstructive air way disease (OAD) ; Oversensitive bronchial system ; Histamine receptors ; Histamin ; Bronchokonstriktion ; überempfindliches Bronchialsystem ; Histamin-Rezeptoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es besteht eine statistisch strenge Korrelation zwischen dem Anstieg der Histaminkonzentration im arteriellen Plasma und dem Anstieg der Strömungswiderstände in den Atemwegen bei experimentell verursachter allergischer Atemwegsobstruktion. Das Histamin wird an sensorischen Rezeptoren im Sinne einer Reflexbronchokonstriktion wirksam. Histamin verursacht in geringen Konzentrationen im Bronchialsystem eine unspezifische Empfindlichkeitssteigerung. Diese kann auch durch Allergene in sehr geringer Konzentration hervorgerufen werden. Patienten mit chronisch obstruktiver Bronchitis haben hohe Histamin-Konzentrationen im Sputum. Durch Waschungen der inneren Oberfläche des Bronchialbaums lassen sich hohe Histamin-Konzentrationen in der Spülflüssigkeit nachweisen. Die Gabe gleicher Histamin-Konzentrationen intravenös verursacht Bronchokonstriktion. Es ist anzunehmen, daß Histamin-Rezeptoren nahe der Oberfläche der Bronchialschleimhaut vorhanden sind. Ebenso müssen in der Oberfläche oder auf der Oberfläche der Bronchialschleimhaut Mastzellen vorhanden sein.
    Notes: Summary There is a statistically strong correlation between the increase of the histamine concentration in the arterial plasma and the increase of airway resistance. The histamine causes a reflex bronchoconstriction on the sensory receptors. Histamine in low concentration increases the unspecific reaction in the bronchial system. This can also be achieved using low concentrations of allergen aerosols. Patients with chronic obstructive bronchitis show high concentrations of histamine in the sputum. The bronchoconstrictive potency of this histamine was found to be not always active. Higher concentrations of histamine can be liberated by washing the inner surface of the bronchial tree. Histamine injected in similar concentrations as that measured in the sputum causes bronchoconstriction. There should be high concentrations of histamine receptors as well as mast cells near the surface of the mucosa of the bronchial wall. There are many questions remaining open, which will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716960
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  • 8
    Electronic Resource
    Electronic Resource
    Possible gravitational microlensing of a star in the Large Magellanic Cloud (1993)
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 621-623 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The MACHO Project7'8 uses the gravitational microlens signature to search for evidence of MACHOs in the Galactic halo, which is thought to be at least three times as massive as the visible disk2. (Two other groups are attempting a similar search9'10.) If most of our Galaxy's dark matter resides ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/365621a0
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  • 9
    Electronic Resource
    Electronic Resource
    Feline immunodeficiency virus infection: plasma, but not peripheral blood mononuclear cell virus titer is influenced by zidovudine and cyclosporine (1993)
    Springer
    Archives of virology 132 (1993), S. 67-81 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The plasma and peripheral blood mononuclear cell (PBMC) titer of feline immunodeficiency virus (FIV) in experimentally infected cats was assessed following administration of either zidovudine or cyclosporine. Treatments were begun 24 h post infection (p.i.) and continued for 4 weeks. Zidovudine treatment did not prevent establishment of infection with FIV, but plasma virus titers were significantly lower than controls at 2 weeks p.i. This reduction of plasma virus titer by zidovudine was not maintained at subsequent sampling times. Similarly, cyclosporine treatment initially lowered plasma virus titers at 2 weeks p.i., but at 4 weeks p.i. the plasma virus titers in cyclosporine-treated cats were significantly higher than in the untreated group. In the untreated group, plasma virus titers declined rapidly to an undetectable level by 14 weeks p.i. Neither zidovudine or cyclosporine treatment significantly influenced the titer of FIV in PBMCs. In all groups (untreated, zidovudine and cyclosporine) the titers in PBMC were high for the duration of the experiment. The decline in plasma virus titers in immunocompetent cats combined with the effect of cyclosporine on plasma titers strongly suggests that the immune system plays a major role in clearing FIV from plasma. In contrast, it appears that the immune response has little impact on PBMC virus titers. This shows that for complete assessment of antiviral agents, both cell-free and cell-associated virus titers must be examined. We also suggest that the limitation of viral titers in PBMC may be of critical importance in the control of lentiviral infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309844
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  • 10
    Electronic Resource
    Electronic Resource
    Consolidation of amorphous powders by the forced rolling process (1990)
    Springer
    Journal of materials science 9 (1990), S. 195-197 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00727713
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