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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 285 (1993), S. 415-417 
    ISSN: 1432-069X
    Keywords: Sphingolipids ; Ceramides ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We measured six stratum corneum sphingolipid species (ceramides 1–6) in 26 males and 27 females, and found a significant change in their percentage composition only among female subjects of different age groups. There was a significant increase in ceramide 1 and 2 with a corresponding decrease in ceramide 3 and 6 from prepubertal age to adulthood. Thereafter the ratio of ceramide 2 to total sphingolipids decreased with age in contrast to ceramide 3 which showed an increase. Such a pattern of change in the aging population is different from that observed in scaly skin experimentally induced by tape stripping. The present results suggest a significant influence of female hormones on the composition of stratum corneum sphingolipids. Moreover, the different patterns of change in sphingolipid composition of stratum corneum lipids between scales from inflammatory skin and those from aged skin also suggest that epidermal biosynthesis of sphingolipids is influenced by epidermal proliferative activity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 249 (1992), S. 181-184 
    ISSN: 1434-4726
    Keywords: Perilymphatic fistula ; Floating labyrinth ; Caloric tesing ; Caloric irregularities ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The term “caloric irregularity” was coined to refer to a gross irregularity in the amplitude and/or frequency of a caloric-induced nystagmus, having a variable slow-phase velocity and prolonged duration. Twelve of 46 guinea pigs with experimentally induced perilymphatic fistula had irregular responses to the ice-water caloric test 1 week after creation of a fistula. The long-term vestibular consequences in animals with caloric irregularities were either resolution and return to normal function (i.e. caloric return) or continuing deterioration to canal paresis. Morphological examination of ears with caloric irregularity revealed that there had been partial collapse of the membranous labyrinth and the creation of a floating labyrinth.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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