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  • 1
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 176-180 
    Details
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175768
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  • 2
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 156-159 
    Details
    ISSN: 1619-7089
    Keywords: Immunoscintigraphy ; Technetium 99m-labelled antibodies ; CD4-specific (T-lymphocyte) antibodies ; Rheumatoid arthritis ; Localisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P〈0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P 〉 0.01) and only weakly with the late bone scan (P 〉 0.05). According to these data we conclude that99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811445
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  • 3
    Electronic Resource
    Electronic Resource
    Vergleichende Untersuchungen an temperaturbeständigen Pigmenten auf Basis 3-Amino-phthalsäureimid. I (1971)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 313 (1971), S. 301-308 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurden hochtemperaturbeständige Azopigmente auf der Basis von 3-Amino-phthalsäureimid hergestellt. Durch Einführung von Chlorsubstituenten konnte die Lichtechtheit günstig beeinflußt werden. Die Migrationsechtheit wurde durch Molekülverdopplung entscheidend verbessert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19713130215
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  • 4
    Electronic Resource
    Electronic Resource
    Source of the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of cambendazole (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 190-191 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined gas chromatography-mass spectrometry and isotope labeling techniques have been employed to demonstrate that the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of 2-thiazolyl-5-isopropoxycarbonylaminobenzimidazole (cambendazole), is derived wholly from the parent drug. [15N] Thiazole-labeled cambendazole was administered to a rat and the metabolite isolated from urine. Trideutero-2-carboxamido-5-isopropoxycarbonylaminobenzimidazole was employed as a carrier to isolate the metabolite in sufficient purity for isotope ratio measurements using multiple ion detection. The metabolite was converted to its tetramethyl derivative by on-column reaction with trimethylanilium hydroxide to permit satisfactory gas chromatography.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010308
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  • 5
    Electronic Resource
    Electronic Resource
    Zur chemisch-thermischen Modifizierung von Kieselgel mit B2O3 (1972)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 393 (1972), S. 50-58 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the chemically thermal modification of gelatinous silica with B2O3The chemically thermal modification of gelatinous silica with boron oxide was studied in dependence on the quantity of impregnated boron oxide, on time, and temperature of the treatment. A. condensation mechanism is discussed on the basis of structure variation of the modification samples.
    Notes: Die chemisch-thermische Modifizierung von Kieselgel mit Boroxid wurde untersucht in Abhängigkeit von der Menge an aufgetränktem Boroxid, von der Zeit und der Temperatur der Thermobehandlung. Ein Kondensationsmechanismus wird im Zusammenhang mit Strukturveränderungen diskutiert.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19723930106
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  • 6
    Electronic Resource
    Electronic Resource
    Zum Ionenaustausch in porösen Gläsern (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 408 (1974), S. 237-246 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Ionexchange on Porous GlassesPorous alkali-boron-silicate glasses show the following sequence of coefficients of the ionexchange-selectivity: \documentclass{article}\pagestyle{empty}\begin{document}$$ {\rm Ti}^{\rm + } 〉 {\rm Ag}^{\rm + } 〉 {\rm K}^{\rm + } 〉 {\rm Na}^{\rm + } 〉 {\rm Li}^{\rm + } . $$\end{document} The degree of ionexchange for divalent ions is only very little. The ionexchange capacity is influenced by the degree of phase-separation of the original glasses and has the origin in BOH groups. The energies of activation for the ionexchange reactions are 10.6-11.8 kcal/mol.
    Notes: An porösen Alkali-Bor-Silikatgläsern konnte folgende Abstufung der Ionenaustausch-Selektivitätskoeffizienten ermittelt werden: \documentclass{article}\pagestyle{empty}\begin{document}$$ {\rm Ti}^{\rm + } 〉 {\rm Ag}^{\rm + } 〉 {\rm K}^{\rm + } 〉 {\rm Na}^{\rm + } 〉 {\rm Li}^{\rm + } . $$\end{document} Der Ionenaustausch für 2wertige Ionen ist nur gering. Die Ionenaustauschkapazität läßt sich auf den Grad der Phasentrennung in den Ausgangsgläsern zurückführen und beruht auf dem Vorhandensein von BOH-Gruppen. Die Aktivitätsenergien für die Ionenaustausch-Reaktionen liegen zwischen 10,6-11,8 kcal/Mol.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19744080303
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