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  • 1990-1994  (4)
  • 1965-1969
  • 1900-1904
  • Immunohistochemistry  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Sinonasal non-Hodgkin's lymphomas and Wegener's granulomatosis: A clinicopathological study (1991)
    Springer
    Virchows Archiv 418 (1991), S. 235-240 
    Details
    ISSN: 1432-2307
    Keywords: Non-Hodgkin's lymphoma ; Wegener's granulomatosis ; Immunohistochemistry ; Nasal cavity ; Paranasal sinuses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reports of sinonasal non-Hodgkin's lymphomas, analysed with monoclonal antibodies, are scarce, and differentiation of these lymphomas from Wegener's granulomatosis can be difficult. In this study, we investigated histopathologically and immunohistologically 20 cases of non-Hodgkin's lymphoma, primary in the sinonasal region, and sinonasal biopsies from 11 patients with Wegener's granulomatosis. All T-cell lymphomas (n=7) and plasmacytomas (n=4) were stage I at clinical presentation, while all B-cell lymphomas (n=9) presented at higher stages. T-cell lymphomas tended to be more frequent in the nasal cavity and paranasal sinuses; B-cell lymphomas more often presented in the nasopharynx. Remarkably, 1 B-cell lymphoma expressed MT1, and 1 T-cell lymphoma expressed L26 (CD 20). The follow-up of 2 patients with a clinical diagnosis of Wegener's granulomatosis was suggestive of non-Hodgkin's lymphoma. Retrospective immunohistochemical analysis revealed that the original histological diagnosis of non-specific inflammation had to be changed to T-cell lymphoma, pleomorphic small cell type. We conclude that a biopsy from the sinonasal region with a dense inflammatory infiltrate, consisting predominantly of Tlymphocytes, renders a diagnosis of Wegener's granulomatosis unlikely and is at least suspicious of T-cell lymphoma. Immunohistochemical analysis is warranted for this type of biopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606061
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis (1991)
    Springer
    Virchows Archiv 418 (1991), S. 271-278 
    Details
    ISSN: 1432-2307
    Keywords: Epithelioid sarcoma ; Soft tissue sarcoma ; Immunohistochemistry ; Marker co-expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606067
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistological and immunoelectron microscopic identification of TNFα in normal human and murine epidermis (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 154-158 
    Details
    ISSN: 1432-069X
    Keywords: TNFα ; Immunohistochemistry ; Immunoelectron microscopy ; Epidermis ; Sebaceous glands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNFα) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane and cytoplasmic labelling of the epidermal keratinocytes, but no labelling of Langerhans cells, melanocytes and Merkel cells. Large amounts of TNFα were regularly found in the sebaceous glands. These findings demonstrate that epidermal keratinocytes and especially sebocytes produce and release TNFα and that this keratinocytederived cytokine may be important for the structural and functional homeostasis of normal epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372709
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Morphology of neurons in the white matter of the adult human neocortex (1992)
    Springer
    Experimental brain research 88 (1992), S. 204-212 
    Details
    ISSN: 1432-1106
    Keywords: Cerebral cortex of man ; Morphology of white matter neurons ; Subplate cells ; Golgi method ; Immunohistochemistry ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurons in the human cerebral cortical white matter below motor, visual, auditory and prefrontal orbital areas have been studied with the Golgi method, immunohistochemistry and diaphorase histochemistry. The majority of white matter neurons are pyramidal cells displaying the typical polarized, spiny dendritic system. The morphological variety includes stellate forms as well as bipolar pyramidal cells, and the expression of a certain morphological phenotype seems to depend on the position of the neuron. Spineless nonpyramidal neurons with multipolar to bitufted dendritic fields constitute less than 10% of the nuerons stained for microtubule associated protein (MAP-2). Only 3% of the MAP-2 immunoreactive neurons display nicotine adenine dinucleotide-diaphorase activity. The white matter pyramidal neurons are arranged in radial rows continuous with the columns of layer VI neurons. Neuron density is highest below layer VI, and decreases with increasing distance from the gray matter. White matter neurons are especially abundant below the primary motor cortex, and are least frequent below the visual cortex area 17. In contrast to other mammalian species, the white matter neurons in man are not only present during development, but persist throughout life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259143
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    Paper (German National Licenses)
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