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  • 1990-1994  (3)
  • 32.80.Fb  (1)
  • Bone dysplasia  (1)
  • Molecular biophysics  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Scaling in the aggregation behaviour of zinc-free insulin studied by small-angle neutron scattering (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 1447-1455 
    Details
    ISSN: 0392-6737
    Keywords: Disperse systems ; Molecular biophysics ; Physical chemistry of solutions of biological macromolecules ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary The aggregation behaviour of zinc-free insulin has been studied by small-angle neutron scattering as a function of protein concentration,pH, and ionic strength of the solution. The distance distribution functions for the 12 samples have been obtained by indirect Fourier transformation. The weight-averaged molecular mass and thez-averaged radius of gyration were determined. Both quantities vary systematically with the experimental conditions. They increase with decreasingpH and with increasing ionic strength. The radius of gyration scales as a power law of the weight-average mass with the exponent 0.44. A similar scaling is found for a set of oligomers structures based on the crystal structure of zinc-free insulin. The mass distribution between the oligomers was determined by a model based on these oligomers. The results from this model and the Fourier transformations have been compared to an equilibrium model recently introduced by Kadimaet al. The model takes into account the variation of the effective charge of the monomer withpH and ionic strength. The neutron scattering results agree well with the predictions of the model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462029
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Campomelic dysplasia — an underdiagnosed condition? (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 331-333 
    Details
    ISSN: 1432-1076
    Keywords: Campomelic dysplasia ; Bone dysplasia ; Incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Campomelic dysplasia (CD) is a rare skeletal dysplasia. The incidence, reported in the literature, is 0.05–0.09 per 10000 live, births. During the period December 1985–December 1990 there were 18350 live births with 4 cases of CD at Aker University Hospital in Oslo, Norway. This gives an incidence of CD in our observation period of 2.2 per 10000. Eliminating our first case, because of Pakistani decent, the total incidence is 1.6 per 10000 among Norwegian infants which is much higher than the incidence previously mentioned. Perhaps CD is under-reported and a high proportion of patients remain undiagnosed. We present four cases and discuss the incidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956747
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plasmon profiles and shapes of sodium cluster ions (1993)
    Springer
    The European physical journal 26 (1993), S. 281-283 
    Details
    ISSN: 1434-6079
    Keywords: 32.80.Fb ; 36.40.+d ; 33.20.Kf
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Photo-absorption cross-sections for charged sodium clusters (14 to 48 atoms) have been measured for photon energies from 2.0 eV to 3.5 eV. The spectra are dominated by surface plasma oscillations of the valence electrons exhausting 70–100% of the dipole sum rule. The mean resonance energy of ≃2.75 eV is nearly independent of cluster size. A splitting of the resonance peaks is observed for non-“magic” clusters and discussed in terms of a deformation picture involving prolate and oblate shapes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01429169
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    Paper (German National Licenses)
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