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  • 1990-1994  (2)
  • Aerobic exercise  (1)
  • Cysteamine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus (1994)
    Springer
    Journal of comparative physiology 175 (1994), S. 677-685 
    Details
    ISSN: 1432-1351
    Keywords: Circadian rhythm ; Suprachiasmatic nucleus ; Cysteamine ; Somatostatin ; Brain slice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Somatostatin is synthesized in the suprachiasmatic nucleus (SCN), a circadian pacemaker in mammals. To explore the functional significance of somatostatin in the circadian system, we examined rhythms of rat locomotor activity and electrical firing rate of SCN neurons in the brain slice after temporal depletion of somatostatin levels in the SCN. Intraperitoneal administration of cysteamine (200 mg/kg), a somatostatin depletor, significantly reduced somatostatin level in the in vivo SCN 5 min after injection and kept low level as long as 3 to 4 days. This administration, on the other hand, induced significant phase advances of about 51 min in the subsequent free-running rhythm of locomotor activity of the rat. A marked phase advance in the circadian rhythm of firing rate in the SCN was also observed after administration of cysteamine in coronal hypothalamic slices. These persistent phase shifts after administration of a somatostatin depletor may suggest that the change of somatostatin level in the SCN have a feedback influence on the circadian pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191840
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of 12 weeks of aerobic exercise plus dietary restriction on body composition, resting energy expenditure and aerobic fitness in mildly obese middle-aged women (1994)
    Springer
    European journal of applied physiology 68 (1994), S. 258-265 
    Details
    ISSN: 1439-6327
    Keywords: Aerobic exercise ; Resting metabolic rate ; Body composition ; Obese women ; Loss of mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the effects of 12 weeks of aerobic exercise plus voluntary food restriction on the body composition, resting metabolic rate (RMR) and aerobic fitness of mildly obese middle-aged women. The subjects were randomly assigned to exercise/diet (n = 17) or control (n = 15) groups. The exercise/diet group participated in an aerobic training programme, 45–60 min · day −1 at 50%–60% of maximal oxygen uptake (VO2max), 3–4 days · week−1, and also adopted a self-regulated energy deficit relative to predicted energy requirements (−1.05 MJ · day −1 to −1.14 MJ · day −1 ). After the regimen had been followed for 12 weeks, the body mass of the subjects had decreased by an average of 4.5 kg, due mainly to fat loss, with little change of fat free mass (m ff). The absolute RMR did not change, but the experimental group showed significant increases in the RMR per unit of body mass (10%) and the RMR per unit of m ff (4%). The increase in RMR/m ff was not correlated with any increase in VO2max/m ff. The resting heat production per unit of essential body mass increased by an average of 21%, but the resting heat production rate per unit of fat tissue mass remained unchanged. We concluded that aerobic exercise enhances the effect of moderate dietary restriction by augmenting the metabolic activity of lean tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376775
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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