ISSN:
1420-9071
Keywords:
In vivo microdialysis
;
striatum
;
noradrenaline
;
L-threo-3,4-dihydroxyphenylserine
;
dopamine release
;
3,4-dihydroxyphenylacetic acid
;
homovanillic acid
;
high performance liquid chromatography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01948006
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