ISSN:
1432-1440
Keywords:
Acquired immunodeficiency syndrome
;
Human immunodeficiency virus
;
Leishmania donovanii
;
Visceral leishmaniasis
;
Kala-azar
;
Intestinal pathogens
;
Kaposi's sarcoma
;
Parasites
;
Parasitic pathogens
;
Interferon-γ
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Visceral leishmaniasis (kala-azar) affecting HIV-infected patient is being reported in increasing frequency. A 40-year-old German bisexual patient with full-blown AIDS is described who presented with Kaposi's sarcoma, epigastric pain, diarrhea, and weight loss but without fever.Leishmania amastigotes were initially found in biopsies from stomach, duodenum, and a cutaneous Kaposi's sarcoma lesion but were later also recovered from bone marrow and lymph node. The patient received three courses of a combination of pentavalent antimony and interferon-γ. In addition to the common side effects such as fever, thrombocytopenia, and elevated amylase and lipase, a vivid progression of the Kaposi's sarcoma was noted. Tumor progression was temporally closely associated with treatment with interferon-γ. Because this phenomemon has also been observed in other patients, we advise caution when using interferon-γ in patients with Kaposi's sarcoma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00577752
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