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  • 1990-1994  (2)
  • Fibroblast  (1)
  • Optokinetic eye movement response  (1)
  • Purkinje cell  (1)
  • Rabbit  (1)
  • [abr] EDTA; ethylenediaminetetraacetic acid
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  • 1
    ISSN: 1432-069X
    Keywords: Intracellular free calcium ; PSS ; Fibroblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular Ca2+ concentrations ([Ca2+]i) in cultured skin fibroblasts from normal subjects and progressive systemic sclerosis (PSS) patients were determined by using Fura-2 and fluorescent videomicroscopy. With the exception of fibroblasts from one PSS patient showing a higher [Ca2+]i, no significant difference was observed in resting [Ca2+]i between the two groups of fibroblasts. Bradykinin (BK) (10 ΜM) induced a transient [Ca2+]i increase in normal fibroblasts, whereas the BK-induced [Ca2+]i increase was reduced or not detectable in PSS fibroblasts. Removal of extracellular Ca2+ did not eliminate the BK-induced [Ca2+]i increase in normal fibroblasts. These findings suggest that BK stimulates Ca2+ release from intracellular stores in human fibroblasts, and also that the BK-mediated Ca2+ release is impaired in PSS fibroblasts.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 80 (1990), S. 221-224 
    ISSN: 1432-1106
    Keywords: Vestibulo-ocular reflex ; Optokinetic eye movement response ; Flocculus ; Purkinje cell ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single-unit activities were recorded from floccular Purkinje cells in 29 alert pigmented rabbits. The floccular areas specifically related to horizontal eye movement (H-zone) were identified by the effects of local stimulation and later confirmed histologically. Most of the 53 H-zone Purkinje cells responded to both vestibular stimulation with turntable oscillation (5° peak-to-peak, 0.1 Hz) in darkness and optokinetic stimulation with dot screen oscillation (2.5°, 0.33 Hz), often showing a preference either for turntable oscillation or screen oscillation. Since these responses were not correlated with the velocity of evoked eye movements or eye position shift, it is concluded that the major inputs to flocculus H-zone Purkinje cells are head velocity or retinal slip signals rather than eye velocity or position signals.
    Type of Medium: Electronic Resource
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