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  • 1990-1994  (2)
  • K252a  (1)
  • butyrate  (1)
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  • 1990-1994  (2)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Increased assembly of cytoskeletal proteins associated with the transformation of human liver cells into fibroblast-like cells (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 495-497 
    Details
    ISSN: 1420-9071
    Keywords: Cytoskeletal proteins ; differentiation ; hepatocyte ; butyrate ; novobiocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A topoisomerase II inhibitor, novobiocin, and a deacetylase inhibitor, butyrate, synergistically transformed human liver cells into fibroblast-like cells. This morphological change was associated with an increased production of procollagen type III peptide and a simultaneous assembly of actin, tubulin, vimentin and cytokeratin. Novobiocin and butyrate had no marked effect on the phosphorylation state of cytokeratin proteins, but synergistically enhanced [3H]acetate uptake. From these results, it can be speculated that protein acetylation plays an important role in inducing the assembly of cytoskeletal proteins and the morphological transformation of human liver cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928172
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    K252a: A new blocker of the cell-cycle at G1 phase in a human hepatoma cell line (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 876-880 
    Details
    ISSN: 1420-9071
    Keywords: K252a ; G1 block ; cell size ; c-myc ; albumin ; HuH7
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The administration of 200 nM K252a to HuH7 suppressed the proliferation of the cells almost completely. The uptake of [3H]thymidine was inhibited, and flow cytometry revealed only one peak at 2C on day 3 after treatment with 100 nM K252a. The expression of proto-oncogene c-myc was not reduced. Despite the blockage at G1, both the size of the cells and the amount of cell protein had increased by 4 times by day 3 after treatment with K252a, while the cells secreted albumin and α-fetoprotein into the medium as usual. These results show that K252a can increase the cell size of HuH7 without losing its function by blocking the cell cycle at G1 phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952601
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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