ISSN:
1432-1238
Keywords:
Key words Continuous hemofiltration
;
Cortisol
;
Catecholamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: To assess the influence of continuous hemodiafiltration (CHDF) on cortisol and catecholamine kinetics in multiple organ dysfunction syndrome. Design: Consecutive clinical study. Setting: General intensive care unit of a university hospital. Patients: Ten adult patients with multiple organ dysfunction syndrome requiring CHDF. Measurements and results: A total of 40 samples were collected during CHDF for cortisol and catecholamine assays. The clearances for cortisol, epinephrine, norepinephrine and dopamine were 2.5±1.7 ml/min, 26.3±2.7 ml/min,16.7±4.2 ml/min and 26.3± 2.6 ml/min (Mean±SE), and their daily extractions were 1.8± 0.2 mg/day, 11.4±4.8 μg/day, 1.0±0.1 μg and 2.3±0.3 μg/day, respectively. There were no significant changes in blood cortisol and catecholamine levels during CHDF conducted for 48 h. Conclusions: The cortisol and catecholamine losses during CHDF were small and unlikely to lead to hemodynamic disturbances.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01709332
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