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Digitale Medien

Granular cell brain tumors of the laboratory rat: an immunohistochemical approach (1991)

Perentes, E. ; Maraziotis, T. ; Qureshi, S. R.

Springer

Acta neuropathologica 82 (1991), S. 112-117

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Details

ISSN: 1432-0533

Schlagwort(e): Rat brain tumors ; Granular cell tumors ; Immunohistochemistry ; Astrocytoma

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00293953

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