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  • 1990-1994  (2)
  • adrenoceptor blockers  (1)
  • thromboxane A2  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 265-268 
    Details
    ISSN: 1432-1041
    Keywords: Diabetes mellitus ; Drug protein binding ; Catecholamines ; adrenoceptor blockers ; prazosin ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In the present study equilibrium dialysis has been used to determine the degree of protein binding of the catecholamines adrenaline and noradrenalin and the adrenergic receptor blockers, prazosin and propranolol in diabetics. The binding of the catecholamines in plasma from Type I and II diabetic patients was not significantly different from that of healthy subjects. The ratio of the bound and free catecholamine concentrations was correlated with the level of albumin (HSA). Significantly reduced protein binding of prazosin was observed in Type I and II diabetic subjects compared to healthy volunteers. The binding of propranolol was significantly reduced in Type I patients. The ratios between the bound and unbound concentrations of prazosin and propranolol were significantly correlated with the levels of a,-acid glycoprotein (AAG). The results suggest that non-enzymatic glycosylation of plasma proteins may increase the unbound fraction of the adrenergic blockers prazosin and propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333020
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Therapeutic lidocaine concentrations have no effect on blood platelet function and plasma catecholamine levels (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 109-111 
    Details
    ISSN: 1432-1041
    Keywords: Lidocaine ; Platelet function ; beta-thromboglobulin ; thromboxane A2 ; catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of therapeutic plasma concentrations of lidocaine on blood platelet function and plasma catecholamine levels were assessed in 9 healthy subjects. There were no significant effects on plasma levels ofβ-thromboglobulin, collagen and adenosine diphosphate-stimulated platelet aggregation, thromboxane-B2-concentration in plasma after collagen and ADP stimulated platelet aggregation, or on plasma nor-adrenaline and adrenaline. No significant correlation could be demonstrated between any of the variables tested. Thus, it appeared that lidocaine had no effect on platelets that could be of benefit in acute myocardial infarction. It should be possible to use lidocaine, in combination with thrombolytic therapies without increasing the risk of bleeding complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280766
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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