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  • 1
    Electronic Resource
    Electronic Resource
    A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 372-376 
    Details
    ISSN: 1432-1076
    Keywords: Respiratory distress syndrome ; Surfactant ; Follow up studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The postnatal growth, respiratory status and neurodevelopmental outcome of surviving babies enrolled in the first European multicentre trial of porcine surfactant (Curosurf) replacement for severe neonatal respiratory distress syndrome, were assessed at corrected ages of 1 and 2 years. Follow up rates of survivors were 93% at 1 year and 89% at 2 years. Treated and control groups were similar at both 1 and 2 years in terms of physical growth, the prevalence of persistent respiratory symptoms and the occurrence of major and minor disability. Serum antibodies recognising Curosurf and surfactant-anti-surfactant immune complexes were detected in both treated and control babies, the titres showing no difference between groups. Examination of histological lung sections from non-survivors revealed a higher incidence of severe pulmonary interstitial emphysema in control babies than in those treated with surfactant. Surfactant treatment for severe respiratory distress syndrome reduces neonatal mortality and air leaks and is not associated with an increase in disability 2 years later.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113261
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maternal haemolysis, elevated liver enzymes and low platelets syndrome: Specific problems in the newborn (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 160-163 
    Details
    ISSN: 1432-1076
    Keywords: HELLP syndrome ; Neonate ; Infant ; Preterm ; Pre-eclampsia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the effects of maternal haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome on the fetus and neonate we retrospectively investigated the outcome of 87 pregnancies. All women showed thrombocytopenia, elevated liver enzymes and haemolysis. None of them died. Nine infants were stillborn (9.9%). Of the 82 liveborn infants, 66 were delivered by caesarian section. Median gestational age of the liveborn infants was 32.6 weeks, mean birth weight was 1576g±699 g (mean±SD). Of these infants, 44% were small for gestational age. Perinatal asphyxia rate was 21.6%. Nine infants died in the 1 st week after birth. Complications during admission included neonatal respiratory disease (43.2%), hyperbilirubinaemia (44.7%), persistent ductus arteriosus (16.2%), thrombocytopenia (34%) and hypoglycaemia (16.2%). Artificial ventilation was necessary in 37 infants. Mean duration of admission was 51 days. HELLP syndrome is associated with poor perinatal outcome; the incidence of caesarian section is high and there is an increased risk for preterm birth and growth retardation. No specific neonatal pathology due to maternal HELLP syndrome was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072496
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Incidence and duration of total occlusion of the radial artery in newborn infants after catheter removal (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 275-277 
    Details
    ISSN: 1432-1076
    Keywords: Percutaneous radial artery cannulation ; Newborn infants ; Radial artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence and duration of total occlusion of the radial artery after catheter removal was determined using repeated Doppler flow measurements. Thirty-two newborn infants with birthweights ranging from 945 g to 3890 g (median 1935 g) and gestational age ranging from 26 to 40 weeks (median 32 weeks) were studied. In 20 out of 32 infants (63%), complete occlusion of the radial artery occurred. The number of occlusions were not related to birthweight, gestational age or duration of cannulation. In all infants, blood flow in the radial artery resumed within 1–29 days after catheter removal. The duration of occlusion was directly related to the duration of cannulation and inversely related to birthweight. This study demonstrates a high frequency of total occlusion of the radial artery in newborn infants after percutaneous radial artery cannulation. In the majority of infants with a radial artert catheter, blood flow to the tissue distal to the cannulation site is dependent solely on the existence of an adequate arterial palmar collateral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106293
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Incidence of forearm and hand ischaemia related to radial artery cannulation in newborn infants (1990)
    Springer
    Intensive care medicine 16 (1990), S. 50-53 
    Details
    ISSN: 1432-1238
    Keywords: Radial artery catheter ; Ischaemia ; Newborn infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the incidence of transient and permanent ischaemia of the forearm and hand caused by radial artery cannulation in a series of 98 newborn infants. Birth weight ranged from 550 to 3920 g (median 1600 g) and gestational age ranged from 26 to 40 weeks (median 31 weeks). In 4 of the 98 infants transient ischaemia of the forearm and/or hand occurred. In three infants the onset of ischaemia was probably related to thrombo-embolic events and in one infant to inadequate palmar collateral circulation. Permanent ischaemic damage with tissue loss did not occur in any infant. It is concluded that permanent ischaemic damage to the forearm and/or the hand with tissue loss, attributable to radial artery cannulation, is seldom encountered in newborn infants. In minimizing the risk of ischaemia, careful assessment of palmar collateral circulation prior to cannulation and of all factors predisposing to the onset of ischaemia is essential. Immediate removal of the catheter at the earliest signs of ischaemia, is essential to prevent ensuing tissue loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01706325
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    Paper (German National Licenses)
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