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  • 1
    Electronic Resource
    Electronic Resource
    Cough due to ace inhibitors: a case-control study using automated general practice data (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 439-444 
    Details
    ISSN: 1432-1041
    Keywords: Key words ACE inhibitors; cough ; epidemiological study ; general practice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract. Objectives: To determine the risk of coughing as an adverse reaction to ACE inhibitors under everyday circumstances in a large population, and to study whether this adverse effect was duration or dose dependent. Design: A population-based case-control study. Setting: Ten general practices of 14 Dutch general practitioners (GP), in which all consultations, morbidity and medical interventions, including drugs prescribed, were registered over the 18 month period from 1st September, 1992 to 1st March, 1994. Subjects: 1458 patients with incident coughing and up to four controls per case were obtained (total 4182 controls), matched for GP. All cases and controls were 20 years or older and had no record of respiratory infection, influenza, tuberculosis, asthma, chronic bronchitis, emphysema, congestive heart failure, sinusitis, laryngitis, haemoptysis or respiratory neoplasms during the study period. Results: Cases were 2.1-times more likely than controls to have been exposed to ACE inhibitors (95% CI 1.5–3.1), but after adjustment the odds ratio was 1.4 (95% CI 0.9–2.1). The crude odds ratio for captopril was 1.3 (95% CI 0.7–2.5), for enalapril 2.6 (95% CI 1.6–4.2) and for lisinopril 2.0 (95% CI 0.5–9.3). The adjusted odds ratio for captopril was 0.9 (95% CI 0.4–1.7), for enalapril 1.7 (95% CI 1.03–2.8) and for lisinopril 1.7 (95% CI 0.4–7.9). For patients who had been on ACE inhibitor treatment for no longer than 2 months the odds ratio was 4.8 (95% CI 1.7–13.3). The odds ratio declined to 2.0 (95% CI 1.1–3.8) for those who had taken an ACE inhibitor for 2–6 months, and to 1.6 (95% CI 0.9–2.7) for those on ACE-inhibitors for more than 6 months. Conclusion: The risk of coughing was increased twofold among ACE inhibitor users, but the odds ratios were no longer significant after controlling for several confounding factors. The risk of developing cough due to ACE-inhibitors declines with the duration of treatment, possibly due to depletion of susceptible persons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050047
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  • 2
    Electronic Resource
    Electronic Resource
    Incidence and duration of total occlusion of the radial artery in newborn infants after catheter removal (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 275-277 
    Details
    ISSN: 1432-1076
    Keywords: Percutaneous radial artery cannulation ; Newborn infants ; Radial artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence and duration of total occlusion of the radial artery after catheter removal was determined using repeated Doppler flow measurements. Thirty-two newborn infants with birthweights ranging from 945 g to 3890 g (median 1935 g) and gestational age ranging from 26 to 40 weeks (median 32 weeks) were studied. In 20 out of 32 infants (63%), complete occlusion of the radial artery occurred. The number of occlusions were not related to birthweight, gestational age or duration of cannulation. In all infants, blood flow in the radial artery resumed within 1–29 days after catheter removal. The duration of occlusion was directly related to the duration of cannulation and inversely related to birthweight. This study demonstrates a high frequency of total occlusion of the radial artery in newborn infants after percutaneous radial artery cannulation. In the majority of infants with a radial artert catheter, blood flow to the tissue distal to the cannulation site is dependent solely on the existence of an adequate arterial palmar collateral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106293
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  • 3
    Electronic Resource
    Electronic Resource
    Cough due to ace inhibitors: a case-control study using automated general practice data (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 439-444 
    Details
    ISSN: 1432-1041
    Keywords: ACE inhibitors ; cough ; epidemiological study ; general practice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: To determine the risk of coughing as an adverse reaction to ACE inhibitors under everyday circumstances in a large population, and to study whether this adverse effect was duration or dose dependent. Design: A population-based case-control study. Setting: Ten general practices of 14 Dutch general practitioners (GP), in which all consultations, morbidity and medical interventions, including drugs prescribed, were registered over the 18 month period from 1st September, 1992 to 1st March, 1994. Subjects: 1458 patients with incident coughing and up to four controls per case were obtained (total 4182 controls), matched for GP. All cases and controls were 20 years or older and had no record of respiratory infection, influenza, tuberculosis, asthma, chronic bronchitis, emphysema, congestive heart failure, sinusitis, laryngitis, haemoptysis or respiratory neoplasms during the study period. Results: Cases were 2.1-times more likely than controls to have been exposed to ACE inhibitors (95% CI 1.5–3.1), but after adjustment the odds ratio was 1.4 (95% CI 0.9–2.1). The crude odds ratio for captopril was 1.3 (95% CI 0.7–2.5), for enalapril 2.6 (95% CI 1.6–4.2) and for lisinopril 2.0 (95% CI 0.5–9.3). The adjusted odds ratio for captopril was 0.9 (95% CI 0.4–1.7), for enalapril 1.7 (95% CI 1.03–2.8) and for lisinopril 1.7 (95% CI 0.4–7.9). For patients who had been on ACE inhibitor treatment for no longer than 2 months the odds ratio was 4.8 (95% CI 1.7–13.3). The odds ratio declined to 2.0 (95% CI 1.1–3.8) for those who had taken an ACE inhibitor for 2–6 months, and to 1.6 (95% CI 0.9–2.7) for those on ACE-inhibitors for more than 6 months. Conclusion: The risk of coughing was increased twofold among ACE inhibitor users, but the odds ratios were no longer significant after controlling for several confounding factors. The risk of developing cough due to ACE-inhibitors declines with the duration of treatment, possibly due to depletion of susceptible persons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195928
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  • 4
    Electronic Resource
    Electronic Resource
    Differential expression of the rat homeobox genes in neural cell lines
    Amsterdam : Elsevier
    Molecular and Cellular Neuroscience 2 (1991), S. 172-178 
    Details
    ISSN: 1044-7431
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/1044-7431(91)90010-L
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  • 5
    Electronic Resource
    Electronic Resource
    A heavy ion beam probe for the Madison Symmetric Torus : Proceedings of the 12th topical conference on high temperature plasma diagnostics (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 963-966 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A heavy ion beam probe (HIBP) is being developed for application on the Madison Symmetric Torus (MST). It will be used to make measurements of the plasma space potential Φ(r), fluctuations in potential Φ˜(r), the electron density ne(r), fluctuating electron density ñe(r), and radial electric field Er(r) from the core to the edge region of the plasma in MST. While information on these quantities can and has been obtained with probes inserted in the surface region, none of the above measurements have been made in the core of a hot reversed field pinch. Measurements of Φ(r), Er(r), and ne(r) have been well established in previous HIBP systems on tokamaks such as Impurities Studies Experiment, Texas Experimental Tokamak (TEXT), and TEXT Upgrade, stellarators such as Advanced Toroidal Facility and Compact Helical System and Bumpy Tori such as Elmo Bumpy Torus and Nagoya Bumpy Torus. Less well developed in terms of HIBP measurements are equilibrium and fluctuating magnetic fields. Because the confining field on MST is determined by plasma conditions, some effort has been made in the design of the MST beam probe to make it possible to characterize B before, during, and after the plasma discharge. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149477
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  • 6
    Electronic Resource
    Electronic Resource
    Sweep system design for a heavy ion beam probe on Madison Symmetric Torus : Proceedings of the 12th topical conference on high temperature plasma diagnostics (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 967-970 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The sweep system for the heavy ion beam probe on the Madison Symmetric Torus (MST) is described. The two components of the system are the primary sweep optics and secondary collimation plates. Key issues in the sweep system design are the small entrance and exit ports available on MST, the significant toroidal beam motion induced by the strong poloidal magnetic field, and the excessive current loading due to plasma and ultraviolet (UV). The design accommodates these issues using a crossover sweep plate design in two dimensions for the primary beam as well as two dimensional sweeping on the secondary beam. The primary beam sweep design results in a sweep range of ±20° in one direction and ±5° in the perpendicular direction. The secondary beam sweep design results in entrance angles to the energy analyzer of 〈3° in radial and ∼0° in toroidal directions. The procedure for calculating sweep performance including fringe fields, a system for active trajectory control, and initial experiments on plasma and UV loading are also discussed. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149418
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  • 7
    Electronic Resource
    Electronic Resource
    Calibration and initial operation of the HIBP on the MST : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 564-567 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the first time, a heavy ion beam probe (HIBP) has been installed on a reversed field pinch, i.e., Madison symmetric torus (MST), to measure the plasma potential profile, potential, and electron density fluctuations, etc. The application of a HIBP on MST has presented new challenges for this diagnostic. The primary sources of difficulty are small access ports, high plasma, and, ultraviolet (UV) flux and a confining magnetic field produced largely by plasma currents. The requirement to keep ports small so as to avoid magnetic field perturbations led to the development of the cross-over sweep system. The effectiveness and calibration of this sweep system will be reported. In addition, this diagnostic is now operating with greater plasma/UV loading effects than most previous Rensselaer HIBPs. The plasma flux is reduced by using a magnetic suppression structure. The UV flux appears to be the dominant cause of the remaining loading, which is substantial. The magnetic field being largely produced by the plasma makes determination of measurement locations exclusively from trajectory calculations difficult. Initial operation results have shown that the magnetic field model we are using to calculate our ion trajectories has an inaccuracy of about 10%, and thus subsequent development of improved confining field models is important. Secondary signals have been detected, and the levels are smaller than that from the UV induced noises. Methods to increase the signal levels are discussed. A very rough estimation of the potential at a typical MST core location is 0.8–2 kV. Fluctuations in the frequency range 100–20 kHz have also been observed. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1310590
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  • 8
    Electronic Resource
    Electronic Resource
    Suppression of plasma electrons in the diagnostic ports of the MST : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 568-571 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The recent application of a heavy ion beam probe (HIBP) to the Madison Symmetric Torus (MST) has motivated the development of permanent magnet plasma suppression structures. Unconfined plasma at the MST diagnostic ports is free to flow out the ports and into adjoining diagnostic chambers. The HIBP system incorporates seven pairs of high voltage, electrostatic steering plates. Stray charged particles that exit the MST-HIBP ports are attracted to these biased steering plates, loading down the power supplies, and detrimentally affecting the desired operation of the plates. A second source of loading is electron current generated by UV light emitted from the MST plasma. Structures comprised of steel keepers and nickel plated magnets were designed to conform to the walls of the two HIBP diagnostic ports. The magnetic fields in the keeper aperture are able to suppress most of the plasma that would otherwise flow into the HIBP chambers. The fields external to the keeper structure are sufficiently small to avoid perturbing the confining fields at the plasma edge. Analysis indicates that electron current from UV radiation dominates the remaining loading of the HIBP steering plates. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1318247
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  • 9
    Electronic Resource
    Electronic Resource
    In-plane orientation control of (001)YBa2Cu3O7−δ grown on (001)MgO by pulsed organometallic beam epitaxy (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 68 (1996), S. 3037-3039 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Thin films of (001) YBCO are grown on epitaxially polished (001) MgO by pulsed organometallic beam epitaxy. The in-plane orientation of the film is controlled by the thickness of a BaO layer, grown in situ, prior to the YBCO growth. For thin BaO layers (〈≈7×1014 Ba/cm2) the films grown [110]YBCO(parallel)[100]MgO. For thick BaO layers ((approximately-greater-than)≈11×1014 Ba/cm2) the films grow [100]YBCO(parallel)[100]MgO. A mechanism that relates the change in YBCO in-plane orientation to a change in the structure of the initial BaO layers with BaO thickness is described. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.115569
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  • 10
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary x-ray analysis of the auto-inhibited twitchin kinase
    Amsterdam : Elsevier
    Journal of Molecular Biology 236 (1994), S. 1259-1261 
    Details
    ISSN: 0022-2836
    Keywords: X-ray crystallography ; auto-inhibition ; crystals ; pseudosubstrate ; twitchin kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-2836(94)90026-4
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