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  • 1
    Electronic Resource
    Electronic Resource
    Auto-oxidative damage in cement dermatitis (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 288-292 
    Details
    ISSN: 1432-069X
    Keywords: Cement dermatitis ; Oxygen intermediates ; Dapsone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxygen intermediates (OIs) generated by stimulated polymorphonuclear leukocytes (PMNs) are known to induce auto-oxidative tissue damage at the site of inflammation. PMNs from five patients with severe and chronic cement dermatitis generated markedly increased levels of OIs. However, only a slight increase in OI generation by PMNs was observed in cement workers without cement dermatitis. Dapsone, which has recently been shown to decrease OI levels, was found to be clinically effective in the treatment of cement dermatitis in these five patients. After treatment, a significant decrease in OI generation was observed in all patients studied. In skin tissues from the cement workers without cement dermatitis, enhanced superoxide-dismutase (SOD) activities as well as increased OI generation by PMNs were noted. In spite of the greatly increased OI generation by PMNs, the SOD activities in the patients were comparable to those in healthy controls. These findings suggest that the severe skin manifestations in patients with cement dermatitis can partly be explained by a defective capacity for enhancing SOD activity which removes increased PMN-derived OIs and thus prevents subsequent tissue injury by OIs at the site of inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509082
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The fate of experimental cutaneous candidiasis in guinea pigs under the suppressed polymorphonuclear leukocyte chemotaxis by colchicine (1981)
    Springer
    Archives of dermatological research 271 (1981), S. 373-380 
    Details
    ISSN: 1432-069X
    Keywords: Candida albicans ; Polymorphonuclear leukocyte ; Colchicine ; Chemotaxis ; Candida albicans ; polymorphonucleäre Leukocyte ; Colchicin ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Experimentelle Hautinfektion mit Candida albicans bei Meerschweinchen wird histologisch durch intensive epidermische Akkumulation der polymorphonuclearen Leukocyten (PMN) charakterisiert. Um die Rollen der PMN in vivo zu studieren, injizierten wir i.p. 250 μg Colchicin/kg, einen potenten Inhibitor der PMN-Chemotaxis, und beobachteten Einflüsse der reduzierten PMN-Migration bei der experimentellen Candidiasis, mit spezialem Interesse am Eliminationsverlauf des Organismus. Es gab bei der Colchicin-behandelten Gruppe eine signifikante Verzögerung mit der Abnahme der epidermischen PMN-Infiltration und der Verlängerung des sichtbaren Schuppenprozesses. Unsere Daten zeigen, daß die Verzögerung der epidermischen PMN-Migration dem Verschwinden des Organismus aus der infizierten Haut entspricht und daß PMN in der Abwehr gegen die Candida-Infektion, besonders in dem Eliminationsverlauf, eine wichtige Rolle spielen.
    Notes: Summary Experimental cutaneous Candida albicans infections in guinea pigs are histologically characterized by intense epidermal polymorphonuclear leukocyte (PMN) accumulation. To study the role of PMNs in vivo, we injected 250 μcolchicine/kg i.p., a strong inhibitor of PMN chemotaxis, and observed the influence of reduced PMN migration in experimental cutaneous candidiasis with special interest in the elimination course of the organisms. There was a significant delay in the clearance of the organisms in the colchicine-treated group with decreased epidermal PMN infiltration and prolonged visible scaling process. Our data suggest that the delay of epidermal PMN migration parallels the disappearance of the organisms from the infected skin and that PMNs play an important part in defense against candida infections especially in the elimination process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406681
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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