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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 277 (1985), S. 288-292 
    ISSN: 1432-069X
    Keywords: Cement dermatitis ; Oxygen intermediates ; Dapsone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxygen intermediates (OIs) generated by stimulated polymorphonuclear leukocytes (PMNs) are known to induce auto-oxidative tissue damage at the site of inflammation. PMNs from five patients with severe and chronic cement dermatitis generated markedly increased levels of OIs. However, only a slight increase in OI generation by PMNs was observed in cement workers without cement dermatitis. Dapsone, which has recently been shown to decrease OI levels, was found to be clinically effective in the treatment of cement dermatitis in these five patients. After treatment, a significant decrease in OI generation was observed in all patients studied. In skin tissues from the cement workers without cement dermatitis, enhanced superoxide-dismutase (SOD) activities as well as increased OI generation by PMNs were noted. In spite of the greatly increased OI generation by PMNs, the SOD activities in the patients were comparable to those in healthy controls. These findings suggest that the severe skin manifestations in patients with cement dermatitis can partly be explained by a defective capacity for enhancing SOD activity which removes increased PMN-derived OIs and thus prevents subsequent tissue injury by OIs at the site of inflammation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-069X
    Keywords: Lipid peroxides ; Superoxide dismutase ; Glutathione peroxidase ; Skin burn ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lipid peroxide levels and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in skin lesions, liver, and serum of mice were measured from the 15th min to 6th day after burns were inflicted on their skin. The lipid peroxide levels in the skin lesions were increased at the 24th h and on the 3rd day after the burns were inflicted. However, the SOD activity did not increase but was significantly decreased from the 30th min to 24th h. GSH-Px activity was almost undetectable in both skin and serum. The lipid peroxide levels in the serum were significantly increased and SOD activity slightly increased at the 4th h. The lipid peroxide levels in the liver were elevated at the 4th h and on the 3rd day although a slight decrease was observed at the 8th h. SOD and GSH-Px activities in the liver increased from the 4th to 24th h. The present study illustrates the changes in both burn-induced lipid peroxides in each organ and the induction mechanisms of the activities of oxygen radical scavenging enzyme, SOD, and lipid peroxide processing enzyme, GSH-Px, which responded to oxygen stress.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research/DNA Repair 255 (1991), S. 273-280 
    ISSN: 0921-8777
    Keywords: Cultured fish cells ; Growth arrest ; Host cell reactivation ; Inducible repair ; Photoreactivation ; UV
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research/DNA Repair 236 (1990), S. 77-84 
    ISSN: 0921-8777
    Keywords: CAT assay ; Cultured fish cells ; Host cell reactivation ; Photoreactivation ; UV
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0921-8777
    Keywords: Excision repair ; Fish cells ; Photoreactivation ; Pyrimidine dimers
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied biopsies from twenty-nine patients with pityriasis rosea. All specimens showed features of subacute or chronic dermatitis as previously reported, but sixteen cases (55%) had dyskeratotic cells within the epidermis. Ultrastructurally, these cells contained an aggregation of tonofilaments, many vacuoles and intracytoplasmic desmosomes. Previously, only non-speci fic histological changes had been described in pityriasis rosea, but the presence of dyskeratotic cells seems to be a significant feature.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0031-9422
    Keywords: Calypogeia azurea ; Calypogeiaceae ; anti-inflammatory activity ; anti-ulcer activity. ; cell culture ; sesquiterpenoid ; water-soluble azulene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 9 (1994), S. 287-289 
    ISSN: 1437-9813
    Keywords: Prepubic sinus ; Duplication of urethra ; Infants and children ; Embryology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Congenital prepubic sinus is a rare anomaly: only five pediatric cases have to our knowledge been reported to date. We report two further cases with the sinus extending from the overlying skin through the rectus fascia to the anterior bladder wall. In our first case the opening of the sinus was just 3 cm below the midline inferior to the navel, with concentric, thin smooth-muscle layers. This lesion may represent a mild forme fruste of a midline closure defect. In our second case, the sinus was lined by transitional epithelium in its distal portion with stratified squamous epithelium near the surface, and was also surrounded by a thin smooth-muscle layer. These two cases may represent a variant of epispadiac urethral duplication. Our observations suggest that congenital prepubic sinus and urethral duplication are related embryologically.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 271 (1981), S. 55-61 
    ISSN: 1432-069X
    Keywords: Spontaneously regressing plane warts ; Activated Langerhans cells ; Unusual Langerhans cell granule ; Ultrastructure ; Spontan zurückgehende Plattenwarze ; Aktivierte Langerhanssche Zellen ; Ungewöhnliche Körner der Langerhansschen Zellen ; Ultrastruktur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden die ultrastrukturellen Veränderungen der Langerhansschen Zellen während der spontanen Involution der Plattenwarze untersucht. In den Gebieten mit aktivierten Makrophagen und epidermischen Zellen zeigten die Langerhansschen Zellen, wie in der Kontaktdermatitis, ein Zeichen erhöhter cellulärer Aktivität mit Vermehrung der cellulären Körner. Ungewöhnlich an der feinen Struktur der Körner der Langerhansschen Zellen war, daß der vesiculäre Teil innen mit einer Membrane umgeben wurde und daß dieser Teil häufig in Gestalt einer Schlinge vorkam.
    Notes: Summary Ultrastructural changes of Langerhans cells during spontaneous involution of plane warts were examined. In areas with activated macrophages and epidermal cell interaction, Langerhans cells showed signs of enhanced cellular activity with an increased number of Langerhans cell granules, as in contact dermatitis. The fine structure of Langerhans cell granules, however, was unusual in that the vesicular portion was surrounded internally by a membrane, and this portion frequently occurred independently taking the shape of a loop.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-069X
    Keywords: Azelaic acid ; Neutrophil functions ; Free radical generation ; Acne inflammation ; Hyperpigmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been shown that acne, hyperpigmentation and lentigo malignant are more or less related pathogenetically to reactive oxygen species (ROS). It has recently been reported that azelaic acid is effective in treating these conditions and that it possesses anti-enzymatic and anti-mitochondrial activity, including cytochrome-P450 reductase and 5α-reductase in microsomal preparations with nicotinamide adenine dinucleotide phosphate (NADPH). We therefore investigated the effects of azelaic acid on human neutrophil functions, such as chemotaxis, phagocytosis and ROS generation. ROS generation in a cell-free system was also assessed. The results revealed that neutrophil chemotaxis and phagocytosis as well as ROS generated in a xanthine — xanthine-oxidase system were not significantly changed in the presence of azelaic acid. However, azelaic acid markedly decreased O 2 − and OH generated by neutrophils. It may be concluded that the reported clinical effectiveness of azelaic acid is partly due to its inhibitory action on neutrophil-generated ROS, leading to a reduction both in oxidative tissue injury at sites of inflammation and in melanin formation.
    Type of Medium: Electronic Resource
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