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  • 1
    Digitale Medien
    Digitale Medien
    Effect of ouabain on hemodynamics in acute volume expanded hypertensive dogs (1989)
    Springer
    Basic research in cardiology 84 (1989), S. 319-325 
    Details
    ISSN: 1435-1803
    Schlagwort(e): volumeexpansion ; vasoconstriction ; autoregulation ; Na+−K+-ATPaseinhibitor ; ouabainlike substance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To evaluate possible roles of endogenous Na+−K+-ATPase inhibitors in vasoconstricted blood pressure elevation produced by acute volume expansion, we administered ouabain (Na+−K+-ATPase inhibitor) intravenously (30 μg/kg) for 10 min to dogs, 3 h after volume expansion with dextran in lactated Ringer's solution (20 ml/kg, for 1 h). Acute volume expansion resulted in the elevation of blood pressure associated with an increase in cardiac output. In some dogs the blood pressure remained elevated with gradual increase in total peripheral resistance (Group I) or with sustained high cardiac output (Group II), and in other dogs (Group III) it returned to the control level. Ouabain administration elevated the blood pressure and total peripheral resistance in these groups and sham dogs which did not have volume expansion. And these effects of ouabain were not correlated with the degree of blood pressure or vasoconstriction produced by volume expansion. Thus, it is not likely that endogenous Na+−K+-ATPase inhibitors increased to produce vasoconstricted hypertension after acute volume expansion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01907979
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of two angiotensin II analogues on blood pressure, plasma aldosterone concentration, plasma renin activity and creatinine clearance in normal subjects on different sodium intakes (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 295-299 
    Details
    ISSN: 1432-1041
    Schlagwort(e): angiotensin II analogues ; aldosterone ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; dietics sodium ; plasma renin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Two angiotensin II analogues (AIIA), 1-sarcosine, 8-isoleucine angiotensin II ([Sar1, Ile8]-AII) and 1-sarcosine, 8-alanine angiotensin II ([Sar1, Ala8-AII), were infused in six normal volunteers on high, regular and low sodium diets. The agonist and antagonist activities of these AIIA on blood pressure (BP), plasma aldosterone concentration (PAC), creatinine clearance and plasma renin activity were examined. Both AIIA had agonistic pressor activities in subjects on high and regular sodium diets, [Sar1, Ile8]-AII being more potent than [Sar1, Ala8]-AII. Both AIIA caused similar elevation of PAC in subjects on high and regular sodium diets, and an equally fall in PAC in subjects on a low sodium diet. Both AIIA strongly antagonized the rise in BP, the increase in PAC and the reduction of Ccr induced by AII administration in subjects on all three sodium diets. The results indicate that both AIIA can be used to examine the activity of the renin-angiotensin system in patients with hypertension, and they also suggest that AII interaction with its receptors differs in different target tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561385
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  • 3
    Digitale Medien
    Digitale Medien
    Reserpine, hydrochlorothiazide and pituitary-gonadal hormones in hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 329-332 
    Details
    ISSN: 1432-1041
    Schlagwort(e): reserpine ; hydrochlorothiazide ; pituitary hormones ; gonadal hormones ; hypertension ; serum concentration ; antihypertensive therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Sex histories and serum samples were obtained from 27 hypertensive men before and after 3 months of therapy with either 100 mg of hydrochlorothiazide or 0.25 mg of reserpine daily. Sera were analyzed for testosterone, dihydrotestosterone, estradiol, luteinizing hormone and prolactin. Both drugs effectively lowered blood pressure. The incidence of impaired sexual performance was low and insignificantly different in the two treatment groups. There were no significant changes in serum hormone concentrations as a result of drug therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00558444
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]-and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 7-10 
    Details
    ISSN: 1432-1041
    Schlagwort(e): angiotensin II analogues ; angiotensin II receptors ; 1-sarcosine ; 8-threonine angiotensin II ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; plasma aldosterone concentration ; plasma renin activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The biological effects of 1-Sarcosine, 8-Threonine angiotensin II ([Sar1, Thr8]ANG II) on blood pressure, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were investigated in six normal subjects on an unrestricted diet, and compared with those of 1-Sarcosine, 8-Isoleucine ANG II ([Sar1, Ile8]ANG II) and 1-Sarcosine, 8-Alanine ANG II ([Sar1, Ala8]ANG II). All three ANG II analogues (A II A) showed agonistic pressor activity, that of [Sar1, Ile8]ANG II being greater than that of [Sar1, Thr8]ANG II or [Sar1, Ala8]ANG II. The antagonistic effect of [Sar1, Thr8]ANG II on blood pressure was less than [Sar1, Ile8]ANG II or [Sar1, Ala8]ANG II. Both [Sar1, Ile8]ANG II and [Sar1, Ala8]ANG II increased PAC and blocked the steroidogenic action of ANG II, while [Sar1, Thr8]ANG II showed little effect on PAC. All three A II A caused similar suppression of PRA and showed no inhibitory effect on the decrease in PRA produced by ANG II. These results indicate that [Sar1, Thr8] ANG II is an A II A with weak agonistic pressor action and that it has vascular selective properties. It is also suggested that ANG II receptors in a variety of target organs are heterogeneous.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01061369
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