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  • 1
    Electronic Resource
    Electronic Resource
    DIFFERENTIAL CONTROL OF VASCULAR TONE AND HEART RATE BY DIFFERENT AMINO ACID NEUROTRANSMITTERS IN THE ROSTRAL VENTROLATERAL MEDULLA OF THE RAT (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 21 (1994), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. To test the hypothesis that a central mechanism may play a role in the minimal reflex tachycardia noted in response to peripheral converting enzyme inhibition, we compared the effects of intravenous (i.v.) ceronapril (CER) with nitroglycerin (NTG) on neurotransmitter release in the rostral ventrolateral medulla (RVLM), using an in vivo microdialysis method in pentobarbital anaesthetized rats.2. CER (0.1 mg/kg, i.v.) caused a progressive decrease in glutamate (GLU) release (CER 65 ± 7%vs NTG 83 ± 3% of each baseline at 140 min, P〈0.05) and attenuated the increase in glycine (GLY) release (CER 100 ± 8%vs NTG 122 ± 9%, P〈0.05).3. Prevention of blood pressure reduction due to i.v. CER by concomitant infusion of a subpressor dose of angiotensin II (AII) attenuated the progressive reduction of GLU release (87 ± 4%, P〈0.05 compared with NTG group), whereas GLY release was not affected (106±5%, NS compared with NTG group).4. Perfusion of GLU into this area at approximately physiological concentrations resulted in a sustained tachycardia with an attenuation of the depressor effect of i.v. CER and perfusion of GLY solely lowered blood pressure.5. These results demonstrate that i.v. converting enzyme inhibitor reduces the release of GLU in the RVLM, which was specifically caused by reducing circulating AII, without any effect on GLY release, thus resulting in the reduction of blood pressure with minimal effect on the heart rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1994.tb02554.x
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  • 2
    Electronic Resource
    Electronic Resource
    Photochemistry of N-aryl-2(1H)-pyrimidin-2-ones
    Amsterdam : Elsevier
    Tetrahedron Letters 20 (1979), S. 4211-4212 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(01)86546-1
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Novel synthesis of 2,4-diphenylquinolines
    Amsterdam : Elsevier
    Tetrahedron Letters 21 (1980), S. 2825-2826 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)78617-5
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Cromakalim (BRL 34915) on hemodynamic and electrocardiographic changes induced by endothelin in dogs (1991)
    Springer
    Basic research in cardiology 86 (1991), S. 49-55 
    Details
    ISSN: 1435-1803
    Keywords: endothelin ; electrocardiogram ; hemodynamics ; potassium channel opener ; voltage-dependentcalcium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated whether cromakalim (BRL 34915), a vasorelaxant agent which acts by opening potassium channels, could affect the systemic effects of endothelin, a newly discovered vasoconstrictive peptide. Intravenous administration of endothelin alone (400 pmol/kg) to anesthetized dogs produced blood pressure elevation, which was associated with an increase in cardiac output in the early phase, and was associated with an increase in total peripheral resistance in the late phase. Electrocardiogram showed significant ST-elevation in II, III, and aVL, and ST-depression in a VR and aVL. The same dose of endothelin given to dogs pretreated with cromakalim did not induce these hemodynamic and electrocardiographic changes. Thus, cromakalim, a potassium activator, inhibited the hemodynamic and electrocardiographic actions of endothelin, suggesting that hyperpolarization due to potassium channel activation inhibited the voltage-dependent calcium channel, which is thought to be a major mechanism for the pressor action of endothelin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02193871
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of ouabain on hemodynamics in acute volume expanded hypertensive dogs (1989)
    Springer
    Basic research in cardiology 84 (1989), S. 319-325 
    Details
    ISSN: 1435-1803
    Keywords: volumeexpansion ; vasoconstriction ; autoregulation ; Na+−K+-ATPaseinhibitor ; ouabainlike substance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate possible roles of endogenous Na+−K+-ATPase inhibitors in vasoconstricted blood pressure elevation produced by acute volume expansion, we administered ouabain (Na+−K+-ATPase inhibitor) intravenously (30 μg/kg) for 10 min to dogs, 3 h after volume expansion with dextran in lactated Ringer's solution (20 ml/kg, for 1 h). Acute volume expansion resulted in the elevation of blood pressure associated with an increase in cardiac output. In some dogs the blood pressure remained elevated with gradual increase in total peripheral resistance (Group I) or with sustained high cardiac output (Group II), and in other dogs (Group III) it returned to the control level. Ouabain administration elevated the blood pressure and total peripheral resistance in these groups and sham dogs which did not have volume expansion. And these effects of ouabain were not correlated with the degree of blood pressure or vasoconstriction produced by volume expansion. Thus, it is not likely that endogenous Na+−K+-ATPase inhibitors increased to produce vasoconstricted hypertension after acute volume expansion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907979
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  • 6
    Electronic Resource
    Electronic Resource
    Spectral change in heart rate variability in response to mental arithmetic before and after the beta-adrenoceptor blocker, carteolol (1992)
    Springer
    Clinical autonomic research 2 (1992), S. 267-270 
    Details
    ISSN: 1619-1560
    Keywords: Mental stress ; Sympathetic nervous system ; Spectral analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spectral analysis of heart rate fluctuation was evaluated before and after administration of carteolol, a non-selectiveβ-adrenoceptor-blocker, to investigate the neural regulatory mechanisms underlying the haemodynamic changes induced by mental stress. Mental stress increased blood pressure and heart rate, with an increased low frequency band, and low frequency/high frequency ratio of the power spectral analysis which are indices of sympathetic activity. Carteolol did not change basal and pre-mental stress measurements of blood pressure, heart rate and spectral density. However, carteolol altered the response to mental stress with a decrease in spectral density of the low frequency band and low frequency/high frequency ratio, and an increase in the high frequency component. These results confirm that mental stress elevates blood pressure by activating the sympathetic nervous system, and suggest that blockade of theβ-adrenoceptor attenuates the pressor response by preventing the autonomic responses to mental stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01819547
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    Paper (German National Licenses)
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