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  • 1
    Electronic Resource
    Electronic Resource
    Kinetic oscillations in the catalytic CO oxidation on Pt(100): Computer simulations (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 85 (1986), S. 5328-5336 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The previously observed phenomena of temporal and spatial self-organization during the catalytic oxidation of CO on a Pt(100) surface were computer simulated by use of the cellular automaton technique. The underlying model is footed on the knowledge about the individual reaction steps (adsorption, desorption, surface structural transformation, etc.), which in turn formed the basis of a previous theoretical treatment in terms of the formulation and solution of a set of coupled differential equations. The present result nicely show the formation and propagation of two-dimensional patterns, and they reproduce qualitatively well all the experimental observations. The development of macroscopic patterns even with an a priori perfectly homogeneous surface is a particularly interesting effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.451676
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetic oscillations in the catalytic CO oxidation on Pt(100): Periodic perturbations (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 742-749 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Periodic modulations of oxygen pressure or temperature were applied in the catalytic oxidation of CO on a Pt(100) surface under isothermal, low pressure conditions. Transitions from aperiodic autonomous oscillations to regular phase-locked behavior could be observed. Computer simulations using a stochastic cellular automaton model yielded qualitatively similar results. The spatial distribution in both experiment and simulation varies essentially in phase over the whole surface area under the influence of the periodic perturbation, while wave propagation in the autonomous system causes more irregular overall behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453572
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanisms of spatial self-organization in isothermal kinetic oscillations during the catalytic CO oxidation on Pt single crystal surfaces (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 510-521 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The rate of catalytic CO oxidation on Pt(100) and (110) surfaces at low pressures (≤10−4 Torr) and under isothermal conditions may exhibit sustained temporal oscillations which are coupled with periodic transformations of the surface structures between reconstructed and nonreconstructed phases, the latter exhibiting higher oxygen sticking coefficients and hence higher reactivity. With Pt(100) the two surface phases exhibit a much larger difference in reactivity (=oxygen sticking coefficient) than with Pt(110), which effect accounts for the qualitative differences in the oscillatory behavior: if two of the control parameters (say pO2, T) are kept fixed, the third (pCO) may be varied with Pt(100) over a fairly wide range without leaving the oscillatory region. Minor (〈1%) fluctuations of the partial pressures associated with the varying reaction rate are hence without any noticeable effect. Coupling between surface reaction and diffusion causes wave propagation of the surface phase transformations and therefore spatial self-organization, as demonstrated by scanning LEED experiments. With Pt(110), on the other hand, the oscillatory region is very narrow. In this case mass transport through the gas phase as caused by the small pressure variations associated with the reaction lead to synchronization between different parts of the surface. Computer simulations with the cellular automaton technique confirm qualitatively the experimental findings and support the conclusions reached.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456501
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  • 4
    Electronic Resource
    Electronic Resource
    THE INFORMATION CONTENT OF CORPORATE DISCLOSURES OF DIVISIONALIZATION DECISIONS [1] (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 22 (1985), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1985.tb00078.x
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of cortical and medullary thymic epithelial antigens in thymomas. An immunohistological study of 14 cases including a characterization of the lymphocytic compartment (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Four monoclonal antibodies against antigens expressed differentially by the normal thymus epithelium, which define the cortical, medullary and subcapsular compartments, were used for immunohistological characterization of the epithelial cells in 14 thymomas. Furthermore, thymoma-associated lymphocytes were studied with monoclonal antibodies directed against T-lymphocyte differentiation antigens (CD1a, CD3, T-cell antigen receptor). Only four of the 14 thymomas could be classified into either medullary or cortical type thymoma based on the immunophenotype of epithelial cells. Ten cases escaped immunophenotypical classification due to co-expression of medullary and cortical antigens by the tumour cells. This aberration from the normal phenotype might indicate the failure of differentiation of such tumours. The immunophenotype of the associated lymphocytes, on the other hand, made it possible to classify the tumours as cortical (5 cases), mixed (2) and medullary (3) thymomas. Four thymomas escaped this classification scheme due to the absence of lymphocytes (2) or to a hybrid immunophenotype (2). Nevertheless, thymocytes of cortical type clearly predominated and were seen in all thymomas with associated lymphocytes. This feature may constitute a good diagnostic tool in differential diagnosis since, in 28 mediastinal or extramediastinal metastasis of tumours not derived from thymic epithelium and associated with various numbers of lymphocytes, none of them were found to contain CD1a positive lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02181.x
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  • 6
    Electronic Resource
    Electronic Resource
    The distribution of fibronectin in lymph nodes infiltrated by Hodgkin's disease (1983)
    Springer
    Virchows Archiv 400 (1983), S. 319-329 
    Details
    ISSN: 1432-2307
    Keywords: Hodgkin's disease ; Fibronectin ; Fibroblast ; Immunoperoxidase study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tissue distribution of fibronectin (FN) was examined using a commercial anti-FN serum, the peroxidase-anti-peroxidase (PaP) technique, and paraffin sections of 22 lymph nodes affected by Hodgkin's disease. Vascular basement membranes and reticulin fibres are selectively stained and their structural changes in this pathological condition become readily visible. In contrast to the normal lymph node and to Hodgkin's disease with lymphocytic predominance, cases of mixed cellularity disease contain individual and focally grouped cells displaying intracytoplasmic FN. In nodular sclerosis these cells with fibroblast morphology are consistently numerous in the marginal zones of the cellular nodes. Strongly reacting mastocytes probably absorbed the applied anti-serum non-immunologically. All the other cell types giving rise to the varying appearances of Hodgkin's lesions are consistently negative with respect to intracellular FN, including all forms of Hodgkin cells. We conclude that in Hodgkin's disease the immigration of FN-secreting fibroblasts is an integral part of the early sclerosing reaction, which in itself is a defence/repair mechanism closely related to scar formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00612193
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  • 7
    Electronic Resource
    Electronic Resource
    J-chain-producing immunoblastic lymphoma in a case of Richter's syndrome (1982)
    Springer
    Virchows Archiv 396 (1982), S. 213-224 
    Details
    ISSN: 1432-2307
    Keywords: B-CLL ; B-immunoblastic lymphoma ; Richter's syndrome ; J chain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 66-year old male with Richter's syndrome died 52 month after diagnosis of chronic lymphocytic leukaemia (CLL). The clinical course was characterized by a marked IgM hypoglobulinaemia which paralleled a chronically relapsing Herpes simplex infection. Autopsy showed a large retroperitoneal and intraabdominal tumour mass and well defined supradiaphragmatic lymphomas. Histological examination revealed a composite tumour consisting of CLL B-cell type (B-CLL) and immunoblastic malignant lymphoma of B-cell type (B-IbL). The lymphocytes bear μ-chains on their surface and to a lesser extend within their cytoplasm, the obviously defective immunoblasts produce J chains exclusively. Flow cytophotometric data seem to indicate an identical diploid stem line of the two tumours. The majority of the cells are in G0/1 phase. The CLL rarely produces mitoses, however, the IbL has a mitotic rate of 7% and a considerable proportion (33%) of cells in the phase of DNA-synthesis. This is the fourth malignant lymphoma and the second immunoblastic lymphoma to be reported that produces J chain in the absence of immunoglobulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431242
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  • 8
    Electronic Resource
    Electronic Resource
    Lymphoepithelial carcinoma (Schmincke type) as a derivate of the tonsillar crypt epithelium (1984)
    Springer
    Virchows Archiv 405 (1984), S. 85-93 
    Details
    ISSN: 1432-2307
    Keywords: Lymphoepithelial carcinoma ; Peanut lectin ; Ulex europaeus lectin ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten tumours of tonsillar or epipharyngeal localization showing the histological picture of “lymphoepithelial carcinoma” (Schmincke 1921) were examined immunohistochemically using Peanut lectin, Ulex europaeus lectin-I and an antiserum to S-100 protein. The findings suggest a close relationship of this type of carcinoma to the normal tonsillar crypt epithelium. The majority of tumour cells are UEA-I-positive and PNL-negative, as is the crypt epithelium, while oral mucosa is both PNL- and to a lesser extent UEA-I-reactive. Tumour areas expressing this pattern contain a large number of asteroid-shaped PNL-positive histiocytes and arachnoid-shaped histiocytes reacting with anti-S-100 protein; both cell types being probably identical and representing typical elements of the normal tonsillar crypt epithelium. Consequently, the WHO-term “nasopharyngeal carcinoma, undifferentiated type” seems to be inadequate for this type of tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694927
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  • 9
    Electronic Resource
    Electronic Resource
    Conspicuous enterocytic binding pattern for peanut lectin and malignant histiocytosis of the intestine (1983)
    Springer
    Virchows Archiv 399 (1983), S. 245-253 
    Details
    ISSN: 1432-2307
    Keywords: Coeliac disease ; peanut lectin ; malignant histiocytosis of the intestine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present a case of a 33 year old male with a history of early childhood diarrhoea and more recently diagnosed gluten sensitive enteropathy, who died with active disease, ulcerative proctosigmoiditis and desquamative erythrodermia associated with toxin induced shock. Autopsy revealed a tumour restricted to lymph nodes of the mesentery and the retroperitoneum. This is considered to be malignant histiocytosis of the intestine (MIH). Immunohistological examination of the diagnostic jejunal biopsy showed a pathological binding pattern for peanut lectin (PNL) within the enterocytes. This may be an expression of disturbed production or secretion of a product rich in non-reducing terminal D-galactosyl residues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619585
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  • 10
    Electronic Resource
    Electronic Resource
    Primary mediastinal clear cell lymphoma (1986)
    Springer
    Virchows Archiv 409 (1986), S. 79-92 
    Details
    ISSN: 1432-2307
    Keywords: Mediastinal lymphoma ; Clear cell lymphoma ; Immunoglobulin-deficient B cell lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This is a report on 8 mediastinal tumours that occurred in young adults (19–43 years, mean: 29.4); predominantly in females (6/8). Initial symptoms consisted of thoracic pain and venectasia and in only one case in B symptoms. After surgical tumour reduction, radiation and/or chemotherapy, local recurrence was observed in each case under clinical care; abdominal spread is presently suspected in 3 patients; 3 died 11, 13 and 22 months after diagnosis. None developed leukaemia. The tumours are B-cell neoplasms with a characteristic immunophenotype: leucocyte common antigen+, common acute lymphoblastic leukaemia antigen−, B 1-antigen+, surface and cytoplasmic immunoglobulin−. Flow cytometry revealed DNA-diploidy in 7 cases and a moderately (3.2–3.8%) to extremely high (8.0–20.6%) S-phase component. The proliferation associated antigen Ki67 was detectable in 10–60% of the tumour cell nuclei, thus stressing the considerable or rapid growth. Histopathology is characterized by a diffuse growth pattern and a clearness and abundance of cytoplasm of the pleomorphic tumour cells, which vary in size and nuclear morphology from patient to patient. Apoptoses are more numerous than mitoses. Fibrosis and focal necrosis are common, sclerosis is present in 3 cases. We suggest that primary mediastinal lymphoma of B cell type is a novel B-lymphoma variant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00705408
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