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  • 1985-1989  (5)
  • 1975-1979  (1)
  • blood pressure  (3)
  • Carbamazepine  (1)
  • Circadian rhythm  (1)
  • Drug treatment of hypertension
  • Night shift
Datenquelle
Materialart
Erscheinungszeitraum
  • 1985-1989  (5)
  • 1975-1979  (1)
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Haben ACE-Hemmer und Calciumantagonisten die Therapie der Hypertonie verbessert? (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 920-923 
    Details
    ISSN: 1432-1440
    Schlagwort(e): ACE-inhibitors ; Calcium antagonists ; Beta-blockers ; Diuretics ; Drug treatment of hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Angiotensin converting enzyme (ACE)-inhibitors combined with diuretics and, if necessary, with calcium antagonists can be used with good success for the treatment of otherwise resistant hypertension. Calcium antagonists are an alternative for physically active hypertensive patients who complain of muscular fatigue during treatment with beta-receptor-blocking agents. The calcium antagonist nifedipine has made the treatment of hypertensive emergencies much easier than with the use of clonidine and particularly sodium nitroprusside. In order to determine the place of ACE-inhibitors and of calcium antagonists in the treatment of hypertension-particularly in comparison with beta-blockers and diuretics- controlled long-term studies on the prognosis of patients with mild to moderate hypertension and on the incidence of side effects would be required.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01728955
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  • 2
    Digitale Medien
    Digitale Medien
    Diurnal variations of blood pressure in shift workers during day and night shifts (1989)
    Springer
    International archives of occupational and environmental health 61 (1989), S. 463-466 
    Details
    ISSN: 1432-1246
    Schlagwort(e): Shift work ; Night shift ; Blood pressure ; 24-h blood pressure monitoring ; Circadian rhythm
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The dependence of blood pressure upon internal rhythms and the short-term effects of shift rota on the blood pressure were investigated in shift workers. Blood pressure was measured every 30 min using automatic recorders for 24 h in 17 physically working men in a chemical factory during their morning and night shifts. Mean 24-h blood pressures were identical in the morning and night shifts. There were no differences of the mean blood pressure between the respective sleeping phases or between the working periods. The amplitudes of circadian blood pressure variations were equal. There was a phase difference of 8 h corresponding to the lag between the working periods. At this 8-h lag the hourly means of the 24-h blood pressure were closely correlated (r = 0.69). Comparisons of 24-h blood pressure profiles during the first and last days of a night shift week showed that the effects of night work on the blood pressure were already fully developed within the first 24h (r = 0.86). Thus the diurnal variations of the blood pressure are determined by the working and sleeping periods and largely independent of endogenous rhythm. There is no short-term alteration of the mean 24-h blood pressure after shift rota.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00386480
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  • 3
    Digitale Medien
    Digitale Medien
    Plasma dopamine-β-hydroxylase activity and the pressor effect of dopamine infusion in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 197-200 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Dopamine-β-hydroxylase ; dopamine infusion ; blood pressure ; plasma ; man ; inter-individual variation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In order to study the function of dopamine-β-hydroxylase (DBH) in human plasma, dopamine, its natural substrate, was infused intravenously in 22 healthy volunteers. Their plasma DBH activities showed great interindividual variations (31–301 units/ml). The infusion rates of dopamine required to increase systolic blood pressure (BP) by 30 mm Hg differed considerably between the subjects, and ranged from 3,0 to 11,6 µg/kg/min. No correlation could be shown between the various dopamine doses and individual plasma levels of DBH. It was concluded, therefore, that plasma DBH in the blood stream was enzymatically inactive. Experiments with human plasma DBH in vitro also support this interpretation. Consequently, interindividual differences in the effects on BP during dopamine infusion cannot be due to pressor effects of noradrenaline synthesized by plasma DBH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00558329
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  • 4
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of verapamil in patients with renal failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 405-410 
    Details
    ISSN: 1432-1041
    Schlagwort(e): verapamil ; renal failure ; norverapamil ; pharmacokinetics ; haemodialysis ; ECG ; blood pressure ; heart rate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of verapamil was studied in patients with end-stage chronic renal failure and in normal subjects after i.v. injection of 3 mg and a single oral dose of 80 mg. Plasma levels of verapamil and its active metabolite norverapamil were measured by HPLC. After i.v. injection, the terminal phase half-life and total plasma clearance of verapamil in both groups were similar. Haemodialysis did not change the time course of plasma verapamil levels after i.v. administration. After a single oral dose, the plasma levels of verapamil and norverapamil in both groups of subjects were similar. Subsequently, normal volunteers and patients with renal failure were treated for 5 days with oral verapamil 80 mg t.d.s. There was no difference between the 2 groups of subjects in the trough and peak levels of verapamil or of norverapamil. Intravenous and oral administration of the calcium channel blocking agent had similar effects on blood pressure, heart rate and the PR-interval in the electrocardiogram in both groups. The study demonstrated that the disposition of verapamil was similar in normal subjects and in patients with renal failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00544358
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  • 5
    Digitale Medien
    Digitale Medien
    Total and free steady-state plasma levels and pharmacokinetics of nifedipine in patients with terminal renal failure (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 185-189 
    Details
    ISSN: 1432-1041
    Schlagwort(e): nifedipine ; renal failure ; pharmacokinetics ; protein binding ; blood pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The total and free steady-state plasma levels of nifedipine in patients with renal failure have been compared with those in subjects with normal renal function. Studies were done after administration of nifedipine 10 mg t.d.s. p.o. for 5 days, after i.v. infusion of 4·4 mg, and after a single 10 mg oral dose. The systemic clearance of nifedipine after a single i.v.-dose was higher in subjects with renal insufficiency (854 ml/min) than in those with normal renal function (468 ml/min). After the single oral dose the AUC (6100 ng·min·ml−1) and maximum plasma concentration (75.0 ng·ml−1) were lower than in subjects with normal renal function (19300 ng·ml−1; 122 ng·ml−1). The plasma protein binding of nifedipine averaged 95.5% in normal subjects and 94.8% in patients with renal failure. Although free and total steady-state plasma levels of nifedipine tended to be somewhat lower than normal in renal failure, the changes in pharmacokinetics and decreased protein binding of nifedipine did not result in a significantly different steady-state plasma level of the drug. The blood pressure response to a given plasma nifedipine level appeared to be enhanced in renal failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00558229
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  • 6
    Digitale Medien
    Digitale Medien
    Plasma protein binding of drugs (1986)
    Springer
    Pharmacy world & science 8 (1986), S. 302-304 
    Details
    ISSN: 1573-739X
    Schlagwort(e): Blood specimen collection ; Carbamazepine ; Dialysis ; Digitoxin ; Lipolysis ; Protein binding ; Therapeutic drug monitoring ; Ultrafiltration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02280056
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