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CURRENT PRACTICE AT THE ROYAL ADELAIDE HOSPITAL SKIN CLINIC (1976)

Hunter, G. A. ; Kirk, J. ; Reid, J. G.

Oxford, UK : Blackwell Publishing Ltd

Australasian journal of dermatology 17 (1976), S. 0

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ISSN: 1440-0960

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The three Senior Visiting Dermatologists at the Royal Adelaide Hospital are in substantial agreement regarding the management of psoriasis, with only minor variations in prescriptions for topical applications. This paper attempts to set out our present views and practice in the management of psoriasis at both in-patient and out-patient levels.The place of various local applications such as tar preparations, dithranol and corticosteroids in the various types and phases of psoriasis is discussed.The indications for and contra-indications to the use of methotrexate are considered. These are now becoming reasonably clear. The use of hydroxyurea, which is a more recent introduction, is also discussed. The use of a combination of these two drugs sequentially or at the same time in the light of our limited experience is also mentioned.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1440-0960.1976.tb00799.x

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The pharmacokinetics of ketoconazole after chronic administration in adults (1987)

Badcock, N. R. ; Bartholomeusz, F. D. ; Frewin, D. B. ; [et al.]

Springer

European journal of clinical pharmacology 33 (1987), S. 531-534

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ISSN: 1432-1041

Keywords: ketoconazole ; pharmacokinetics ; antimycotic drug

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary We have studied the pharmacokinetics of the anti-mycotic ketoconazole in seven patients who took it for 1–6 months at a dose of 200 mg daily. The mean elimination half-life of the drug was 3.3 h, and although the ketoconazole was given only once daily, a satisfactory clinical response was obtained in all seven individuals. Only a small fraction of the absorbed drug (mean 0.22%) was excreted unchanged in the urine, suggesting almost complete metabolism. Our results support the concept that anti-mycotic activity in the tissues continues after the plasma drug concentration has fallen below a critical level. Our results also support the concept of a change in pharmacokinetics with chronic dosing.