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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 4351-4357 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 4617-4618 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 33 (1987), S. 531-534 
    ISSN: 1432-1041
    Keywords: ketoconazole ; pharmacokinetics ; antimycotic drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of the anti-mycotic ketoconazole in seven patients who took it for 1–6 months at a dose of 200 mg daily. The mean elimination half-life of the drug was 3.3 h, and although the ketoconazole was given only once daily, a satisfactory clinical response was obtained in all seven individuals. Only a small fraction of the absorbed drug (mean 0.22%) was excreted unchanged in the urine, suggesting almost complete metabolism. Our results support the concept that anti-mycotic activity in the tissues continues after the plasma drug concentration has fallen below a critical level. Our results also support the concept of a change in pharmacokinetics with chronic dosing.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 17 (1976), S. 0 
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The three Senior Visiting Dermatologists at the Royal Adelaide Hospital are in substantial agreement regarding the management of psoriasis, with only minor variations in prescriptions for topical applications. This paper attempts to set out our present views and practice in the management of psoriasis at both in-patient and out-patient levels.The place of various local applications such as tar preparations, dithranol and corticosteroids in the various types and phases of psoriasis is discussed.The indications for and contra-indications to the use of methotrexate are considered. These are now becoming reasonably clear. The use of hydroxyurea, which is a more recent introduction, is also discussed. The use of a combination of these two drugs sequentially or at the same time in the light of our limited experience is also mentioned.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-7217
    Keywords: adjuvant therapy ; breast cancer ; ovarian irradiation ; prednisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following mastectomy, patients with operable breast cancer underwent postoperative irradiation of the chest wall and regional lymph nodes. They were then assigned at random to receive no further therapy, ovarian irradiation (2000 rad in five days) or ovarian irradiation in the same dosage plus prednisone, 7.5 mg daily. A total of 705 patients received the randomly assigned treatment and were followed for up to 15 years. In premenopausal patients who received ovarian irradiation, the recurrence of breast cancer was delayed and survival prolonged, but not significantly. In premenopausal women aged 45 years or more, ovarian irradiation plus prednisone therapy significantly delayed the recurrence of breast cancer (p = 0.04) and prolonged survival (p = 0.02). No value was demonstrated for ovarian irradiation with or without prednisone therapy in postmenopausal patients.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 22 (1994), S. 692-706 
    ISSN: 1573-9686
    Keywords: Magnetic resonance imaging ; Segmental parameters ; Mass ; Center of mass ; Moment of inertia ; Trunk ; Thorax ; Abdomen ; Pelvis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The purpose of this study was to evaluate the segmental parameters of the human trunk of malesin vivo using magnetic resonance imaging (MRI). In addition, the efficacy of volumetric estimation and existing prediction formulas to produce segmental properties similar to those produced by MRI was evaluated. As opposed to finding one representative normal value for these parameters, a range of normal values was defined. For instance, the average trunk mass was 42.2%±3.5% (x±SD) of body mass, but values ranged from 35.8% to 48.0%. To account for segment parameters more accurately, specific anthropometric measures need to be considered in addition to overall measures of body height and mass. These specific measures included segment length, circumference, width, and depth. Studies reporting general percentages based on height and/or mass were found to be inadequate predictors of segmental parameters of the trunk compared with MRI estimates. Volumebased estimates, which assume a uniform density distribution within a segment, were found to correspond closely to MRI values except for the thorax. However, the use of density values reflective of the livingin vivo state would likely alleviate this disparity, thus indicating that the volumetric technique may be effective for deriving segmental parameters for large segments of the trunk. Future research should adopt noninvasive techniques such as MRI and/or volumetric estimation to enhance the predictability of segmental parameters of the body for specific population groups characterized by gender, developmental age, body type, and fitness level. Further efforts should be made to establish standardized boundary definitions for trunk segments to avoid unnecessary confusion, from which substantial errors may be introduced into biomechanical linked-segment analyses of human movement.
    Type of Medium: Electronic Resource
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