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  • 1
    Electronic Resource
    Electronic Resource
    Conductivité électrique totale de sels doubles de type iodure d'argent—polydiiodure de N pentylène N′ alkylène tétraméthyl N, N, N′, N′, diammonium (1986)
    Springer
    Journal of applied electrochemistry 16 (1986), S. 505-512 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Description / Table of Contents: Abstract Ionenes with the formula {[NMe2(CH2)5NMe2(CH2) n ]2I}p (where Me=methyl group;n=3, 4, 5; andp the degree of polymerization) have been prepared. Their NMR and IR spectra are shown and discussed. When these compounds are associated with silver iodide they give conducting compounds which obey the Arrhenius law. The highest conductivity of the AgI−N-pentylene, N′-alkylene, N, N, N′, N′-tetramethyl diammonium polyiodide system, at 25°C, is 0.01 Ω cm−1, corresponding to a compound containing 80% of AgI equivalent. This study has been carried out with the purpose of achieving solid generators.
    Notes: Résumé Les ionènes de formule {[NMe2(CH2)5NMe2(CH2) n ]2I}p (avec Me=radical méthyl;n=3, 4, 5; etp le degré de polymérization) ont été préparés. Leur spectre RMN et IR est présenté et discuté. Associés à de l'iodure d'argent, ils donnent des composés conducteurs qui suivent la loi d'Arrhénius. Le système AgI-polydiiodure de N pentylène N′ propyléne tétraméthyl N, N, N′, N′ diammonium possède à 25°C une conductivité maximale de 0.01 Ω cm−1 pour une composition renfermant 80% en équivalent de AgI. Cette étude se place dans une perspective de mise au point de générateurs tout solide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006845
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  • 2
    Electronic Resource
    Electronic Resource
    Tierexperimentelle Erfahrungen mit einer neuen transvenösen Katheter-Elektrode (1973)
    Springer
    Research in experimental medicine 161 (1973), S. 298-303 
    Details
    ISSN: 1433-8580
    Keywords: The behaviour of the catheter electrode in animal experiments ; Transvenöse Katheter-Elektrode im Tierexperiment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Tierexperimentelle Untersuchungen mit der transvenösen Katheter-Elektrode MIP 2000 bei insgesamt 20 Hunden (Verweildauer der Elektroden zwischen 1 und 12 Wochen) ergaben, daß durch den dargestellten Mechanismus der Elektrode der Elektrodenkopf am Myokard fest verankert war. Eine überschießende Bindegewebsreaktion durch „Ausfahren” von 4 Kunststoffborsten in das Myokard findet nicht statt, ebenso bewirkt der Mechanismus der Elektrode keine erhöhte Reizschwelle.
    Notes: Summary Experimental investigations with the transvenous catheter electrode MIP 2000 (the electrodes remained inserted from 1 to 12 weeks) on 20 dogs proved the tight fastening of the electrode point to the myocardium by the outlined mechanism. There is neither an excessive reaction of the connective tissue by the “intrusion” of the 4 plastic bristles into the myocardium nor does the electrode mechanism produce an elevated stimulus threshold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851453
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  • 3
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Untersuchungen über das Verhalten glatter Muskelzellen in der Arterienwand unter verschiedenen experimentellen Bedingungen (1973)
    Springer
    Virchows Archiv 359 (1973), S. 171-184 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Verhalten glatter Muskelzellen unter experimenteller Hypertonie, Hypercholesterinämie und Transplantation wird untersucht und verglichen. Glatte Muskelzellen können sich in Abhängigkeit von den experimentellen Bedingungen transformieren und die charakteristischen morphologischen Merkmale glatter Muskelzellen weitgehend verlieren. Es wird aufgezeigt, daß die in pathologisch veränderten Gefäßarealen anzutreffenden Zellen von glatten Muskelzellen abstammen.
    Notes: Summary Morphologic studies with the electron microscope were undertaken to point out the role of smooth muscle cells in experimental hypertension, hypercholesterinemia, and transplantation. Fine structural alterations are described and compared. It is shown that smooth muscle cells are able to transform under experimental conditions by loss of their characteristic morphological features. It is assumed that smooth muscle cells play an important role in the formation of pathologic intimal thickenings by migration into the subendothelial space and producing intercellular substances such as acid mucopolysaccharides, collagen and elastic. The smooth muscle cell is also considered to be capable of conversion into foam cell during lipid accumulation in the arterial wall following hypercholesterinemia. Smooth muscle cells are also important in the reparation of alterations in aortic grafts and hosts caused by ischemic and immunological reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548263
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  • 4
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopischer Beitrag zur Kenntnis des Glomus caroticum (Katze) (1971)
    Springer
    Cell & tissue research 112 (1971), S. 494-515 
    Details
    ISSN: 1432-0878
    Keywords: Carotid body (Cat) ; Chemoreceptor cells ; Nerve terminals ; Osmiophilic granules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die submikroskopische Morphologie des Glomus caroticum der Katze wird beschrieben. Zur Anwendung kamen zwei Fixationsmedien: 1.5%iges Glutaraldehyd in 1/15 m Sørensen-Puffer (pH 7,35; 520 Milliosmol) und 2.1%ige Osmiumsäure in 0,1m s-CollidinPuffer (pH 7,35; 310 Milliosmol). Ein Vergleich der Strukturen nach Behandlung mit den beiden Mitteln ergibt erhebliche Differenzen, die in einer Entleerung der osmiophilen Bläschen, Eluation der Gewebsmatrix und der Anwesenheit von inocytosebläschen an den Hüllzell- und Endothelmembranen nach Osmiumsäurefixation (s-Collidin-gepuffert) bestehen. Nach Fixation in Glutaraldehyd (in Sørensen-Puffer) sind diese Erscheinungen nicht vorhanden, hingegen stellen sich die osmiophilen Bläschen immer gefüllt dar. Sie sind auch in Nervenendigungen und in den präterminalen Nervenfasern zu finden. Nach Iversen (1967a, b) enthalten die osmiophilen Bläschen wahrscheinlich ATP und Katecholamine im molaren Verhältnis von 1∶4. Zur Aktivierung von ATP bei einer hypoxischen Stoffwechsellage ist ein Einstrom von Ca2+ Ionen notwendig, die das Membranpotential der Chemorezeptorzellen verändern. Es wird ein Innervationsmechanismus aufgrund dieser Elektrolytverschiebung diskutiert.
    Notes: Summary Ultrastructure of the cat carotid body was studied after fixation in either 1.5% glutaraldehyde in 1/15 Sørensen buffer (pH 7.35; 520 milliosmol), or 2.1% osmium tetroxide in 0.1 M s-collidine buffer. After fixation in osmium tetroxide, the content of osmiophilic granules was depleted, elution of the tissue matrix was observed, and pinocytotic vesicles appeared at covering and endothelial cell membranes. After fixation in glutaraldehyde, these characteristics were not observed and osmiophilic granules were always filled. Osmiophilic granules were also present in nerve endings and preterminal nerve fibers. According to Iversen (1967a, b), the osmiophilic granules probably contain ATP and catecholamines in a 1∶4 molar ratio. To activate ATP in hypoxic states, it appears that Ca2+ ions must diffuse into the chemoreceptor cells to alter their membrane potential. The resulting electrolytic changes appear to be related to carotid body excitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01033376
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  • 5
    Electronic Resource
    Electronic Resource
    Beitrag zur Kenntnis der Glomera coronaria der Katze (1971)
    Springer
    Cell & tissue research 118 (1971), S. 532-554 
    Details
    ISSN: 1432-0878
    Keywords: Glomera coronaria ; Cat ; Chemoreceptor cell ; Blood supply ; Synapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Gefäße der zwischen Aorta ascendens und Truncus pulmonalis, an der Vorder- und Hinterwand des Truncus pulmonalis gelegenen Glomera, sowie das sogenannte „Glomus pulmonale“ der Katze lassen sich von den Coronararterien aus durch Tusche-Gelatine-Lösungen füllen. Die erwähnten Paraganglien sind als Chemoreceptorenfelder dem Coronarkreislauf angeschlossen und daher als Glomera coronaria zu bezeichnen. Licht- und elektronenmikroskopische Untersuchungen ergaben eine morphologische Übereinstimmung mit dem Glomus caroticum. Vagusdurchtrennungen verursachen eine Degeneration der an den Glomuszellen gelegenen synaptischen Formationen sowie Veränderungen in Glomuszellen.
    Notes: Summary The vessels of the glomera that lie between the aorta and the pulmonary trunk, on the anterior and posterior wall of the pulmonary trunk, as well as the so-called glomus pulmonale of the cat have been injected with gelatine-india ink mixture. The paraganglia mentioned above are associated with the coronary circulation as chemoreceptors and are designated as the glomera coronaria. The investigations demonstrate a morphologic similarity with the glomus caroticum. Section of the vagus causes a degeneration of the synaptic structures on the glomus cells as well as changes in the cells themselves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324619
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  • 6
    Electronic Resource
    Electronic Resource
    Immunocytochemical evidence for intragranular processing of pro-opiomelanocortin in the melanotropic cells of the rabbit (1985)
    Springer
    Cell & tissue research 242 (1985), S. 365-370 
    Details
    ISSN: 1432-0878
    Keywords: Melanotrophs ; Immunogold technique ; Secretory vesicles ; γ3-MSH ; α-MSH ; Endorphins ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunogold technique, employing antisera with clear-cut specificities, was used to localise different processing stages of pro-opiomelanocortin (POMC) in rabbit melanotropic cells. While the antiserum against γ 3-MSH labelled all the secretory granules including intrasaccular condensations in the Golgi apparatus, antisera against α-MSH only labelled extra-Golgi secretory vesicles (SV). All extra-Golgi SV were likewise labelled with the three antisera against α-MSH used, despite their different specificities for the desacetylated, N-acetylated or C-amidated forms of the peptide. The antibody against β-endorphin also labelled the extra-Golgi SV, while only some SV were labelled with the antibody against γ-endorphin. These results correlate with biochemical data in favour of mainly — if not exclusively — intragranular processing of POMC. Except for γ3-MSH, the cleavage of which could coincide with Golgi packaging of secretory material, other post-translational modifications of the precursor seem to occur when SV are discharged outside the Golgi area. The cleavage of γ-endorphin appears to be a later step in POMC processing, occurring in some mature SV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214549
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  • 7
    Electronic Resource
    Electronic Resource
    Gase (1931)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 85 (1931), S. 438-454 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441523
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  • 8
    Electronic Resource
    Electronic Resource
    Liver uptake of 99mTc-labeled diphosphonate (DPD) by metastatic lesions from large bowel carcinoma (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 467-468 
    Details
    ISSN: 1619-7089
    Keywords: 99mTc-DPD uptake ; metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Accumulation of 99mTc-diphosphonate was observed in 2 of 12 patients with liver metastases who had primary adenocarcinoma of the large bowel. The area of excessive radionuclide concentration corresponded well to the location of the hepatic metastases. The literature on this subject is reviewed and a possible mechanism of radionuclide accumulation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256594
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  • 9
    Electronic Resource
    Electronic Resource
    The effects of different fixatives for immunofluorescent and immunoperoxidase localization of Factor VIII-related antigen in canine carotid artery and vascular prostheses (1986)
    Springer
    Journal of molecular histology 18 (1986), S. 351-356 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The evaluation of vascular grafts seeded with autologous endothelial cells requires a reliable method of endothelial cell identification. Previous attempts to identify positively tissue Factor VIII-related antigen, found in relatively large amounts in vascular endothelial cells, proved to be inconsistent when immunoperoxidase and immunofluorescent staining techniques were tried. Because the Factor VIII antigen is very labile, this study was performed to determine an optimal fixation technique for demonstrating this antigen in frozen sections of endothelial tissue. Unfixed, acetone-fixed, and formalin-fixed sections of canine carotid artery as well as vascular grafts fixed in 1-ethyl-3-(3-diaminopropyl)-carbodiimide were examined by an indirect immunofluorescence technique. Also, the immunoperoxidase method of Factor VIII identification was applied to unfixed, acetone-fixed, and carbodiimide-fixed endothelial cell seeded vascular grafts. Acetone was the preferred fixative, resulting in excellent antigen preservation with minimal background staining. The immunoperoxidase technique of Factor VIII-related antigen identification was found to be the method of choice because of its sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01675215
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  • 10
    Electronic Resource
    Electronic Resource
    180. Chirurgisch-internistische Kooperation bei der Therapie mit Herzschrittmachern (1971)
    Springer
    Langenbeck's archives of surgery 329 (1971), S. 621-622 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aus der Erfahrung an 497 Herzschrittmacheroperationen in den Jahren 1961\2-1970 m\:ochten wir folgende Punkte hervorheben: 1. Die Behandlung mit Herzschrittmachern ist im wesentlichen ein geriatrisches Problem mit den sich daraus ergebenden Konsequenzen für Indikation, Vorbehandlung, Operation und Nachsorge. Das kann die vergleischweise hohe Letalität erklären. 2. Die Möglichkeit, die letalen and anderen Komplikationen intra- and postoperativ mittels „Vorstimulation” zu verringern, ist gegeben, statistisch ist sie jedoch in Ermangelung ausreichender Fallzahlen noch icht zu sichern. 3. Bei den Fallen von Thorakotomie and Mediastinotomie zur myokardialen Elektrodenfixierung läßt sich die Tendenz eines Unterschiedes zugunsten der Mediastinomie annehmene, auch hier steht der statistische Nachweis aus.
    Notes: Summary Based on our experience gained from 497 cardiac pacemaker implantations carried out in the years 1961–1970, we would like to emphasize the following points: 1. Treatment with cardiac pacemakers is essentially a geriatric problem and therefore these are particular factors to be considered with regard to indications, premedication, surgery and after-care. This also helps to explain the high mortality rate. 2. It is possible to reduce the incidence of fatal and other complications which arise during and after the operation, by means of “preliminary stimulation”. This cannot yet be assessed statistically as the number of cases so treated is not large enough. 3. In the cases where thoracotomy or mediasinotomy was carried out for the purpose of myocardial electrode implantation, a difference in the results, favouring mediatinotomy, was observed, but here again, statistics are not yet available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01770606
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