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  • 1985-1989  (1)
  • 1970-1974
  • ranitidine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 239-242 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; ranitidine ; imipramine demethylation ; desmethylimipramine hydroxilation ; human liver microsomes ; debrisoquine hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cimetidine and ranitidine on the demethylation of imipramine (IMI) and on the hydroxylation of desmethylimipramine (DMI) was studied in microsomes from four human livers. Cimetidine inhibited both demethylation of IMI and 2-hydroxylation of DMI, whilst the effect of ranitidine was not statistically significant. 2-hydroxylation of DMI is probably mediated by debrisoquine hydroxylase, a cytochrome P-450 isozyme that is monogenically controlled. The results suggest that cimetidine inhibits this enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614311
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