ISSN:
1440-1681
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
1. The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists.2. Arotinolol, at concentrations of 10−8 to 10−4 mol/l, inhibited the increasing effect of 10−6 mol/l IP on renin release, in a concentration-dependent manner. Similar results were observed with AC-623, propranolol or labetalol, although the inhibitory potencies of these agents were considerably lower than that of arotinolol.3. The blocking effect of arotinolol on the 10−5 mol/l NE-induced decrease in renin release was much less potent than seen with other α-adrenoceptor blocking agents such as prazosin, phenoxybenzamine and labetalol.4. These data suggest that the potent blocking effects of arotinolol and its metabolite on the increased renin release in response to β-adrenoceptor stimulation may contribute to the antihypertensive effect of this agent.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1440-1681.1986.tb00931.x
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