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  • 1
    Electronic Resource
    Electronic Resource
    Formation of a New Biogenic Aldehyde Adduct by Incubation of Tryptamine with Rat Brain Tissue (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Tryptamine was degraded by incubation with rat brain homogenate to an unknown product. The reaction was stimulated by the nonionic detergents Triton X-100 and Lubrol PX and less by the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio] 1 -propanesulfonate (CHAPS). The same results were obtained with pig brain and bovine brain. The monoamine oxidase inhibitor pargyline inhibited the reaction strongly, indicating the partici pation of the enzyme on the reaction. Addition of 17,000 g supernatant from rat brain homogenate increased the for mation effectively whereas phospholipids or chloroform/methanol (7:3) extract from the 17,000 g supernatant showed only little or no effect. Chromatographic and electrophoretic properties as well as the chemical reaction of the product with specific reagents suggest that the compound consists of an indole part and an amino acid part. The product could be identified by fast atom bombardment mass spectrometry and by comparison with the synthetic substance (4R)-2-(3-indolylmethyl)-1,3-thiazolidine-4-carboxylic acid. It is formed by the enzymatic oxidation of tryptamine producing indole-3-acetaldehyde which sponta neously cyclizes with free l-cysteine from the tissue. The results suggest that the reaction of biogenic aldehydes with brain macromolecules may proceed via an analogous reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb02483.x
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  • 2
    Electronic Resource
    Electronic Resource
    UV multiphoton excitation: An access to the energy dependence of unimolecular reactions and collisional energy transfer (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 3564-3570 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Repetitive absorption of UV (or visible) photons followed by fast internal conversions allows to deposit large amounts of vibrational energy in polyatomic molecules. Intra- and intermolecular processes with relatively weak energy dependences can be studied by this excitation over broad energy ranges. The technique is illustrated for the unimolecular isomerization azulene → naphthalene and collisional energy transfer of vibrationally excited azulene. With ns excimer laser pulses, up to three photons at λ=308 nm were deposited in the molecule, and collisional quenching competing with isomerization was studied. The results can be modeled conveniently by a multistep mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453905
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  • 3
    Electronic Resource
    Electronic Resource
    Electron microscope study of superconductor YBa2Cu3O6+δ (1987)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 20 (1987), S. 505-506 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Electron microscopic observations of small single-crystal grains of YBa2Cu3O6+δ confirmed the orthorhombic symmetry and revealed very fine domain structure with twin boundaries parallel to (110) crystallographic planes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889887086138
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  • 4
    Electronic Resource
    Electronic Resource
    Über den Einfluß verschiedener Pharmaka auf die Eiweißbindung von Phenolrot und Digitoxin (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 277-287 
    Details
    ISSN: 1432-1912
    Keywords: Protein Binding ; Phenol Red ; Digitoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The binding of phenol red and digitoxin to bovine albumin has been measured by means of equilibration dialysis and characterized by the following parameters: binding constant K 1, number of binding sites per albumin molecule n, and free binding energy DF o. Protein binding of phenol red yields a saturation type curve with saturation at about 11.3 mmole/l. Phenylbutazon and probenecid were able to displace phenol red from albumin binding sites in concentrations which are regularly reached after therapeutic doses. With digitoxin because of its hydrophobic character plasma binding could not be measured beyond concentrations of 0.82 mmole/l. Though in principle there is no difference between phenol red and digitoxin binding (a digitoxin binding curve could be calculated also for high concentrations) no displacement effect was seen with probenecid, phenylbutazon, salicylic acid and benzbromaron up to tenfold therapeutic plasma levels. These drugs were effective, however, in the displacement of digitoxin in diluted plasma albumin solutions. This indicates that for an effective displacement multiple molar concentrations of bound and displacing drug with respect to the binding protein are necessary. Displacement from plasma protein therefore plays no role in the possible interference of drugs if one of them is applied in doses far below the molar concentration of the binding proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500056
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  • 5
    Electronic Resource
    Electronic Resource
    Die Wirkung von Probenecid auf die Verteilung von Digitoxin, Digoxin und Ouabain an der Maus (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 267-279 
    Details
    ISSN: 1432-1912
    Keywords: Probenecid ; Cardiac Glykosides ; Distribution ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Distribution studies have been performed on mice with tritium labelled Digitoxin, Digoxin and Ouabain. Contrary to many other species Digitoxin does not lead to an accumulation of radioactivity in the mouse organs. Neither the liver, nor the muscle, nor the kidney concentrations ever reached plasma radioactivity levels; the highest organ concentrations in steady state were found in the liver,and attained between 40 and 50% of plasma radioactivity concentrations. Radiochromatographic controls of these experiments in the liver, bile and plasma showed that Digitoxin is metabolized to a very small extent only and is especially not subject to 12-β-hydroxylation: no Digoxin is demonstrable in liver, bile, plasma, and urine of the mouse following Digitoxin administration. Unlike with Digitoxin is the concentration of Digoxin and Ouabain in the mouse liver very effective. Liver radioactivity after 3H-Digoxin administration is found mostly to be 2–3 fold above plasma level concentrations whereas Ouabain—not metabolized in the mouse—may reach liver concentrations up to 35 times the plasma level. Radioactivity in bile reflects this behaviour: Ouabain bile levels reach the highest values (up to 200 fold) whereas Digitoxin never exceeds plasma radioactivity. When Probenecid was given together with the cardiac glykosides, Digitoxin plasma radioactivity fell to about half of the control values with a slight rise in liver and muscle concentrations. With Digoxin and even more with Ouabain Probenecid inhibited their accumulation in the liver leading to a redistribution into the plasma and muscles with subsequent higher muscle concentrations. The general Probenecid effect was to level out concentration gradients mostly pronounced in the Ouabain experiments where also the effect was achieved with the lowest Probenecid dose (20 mg/kg). A satisfactory explanation for this effet is not yet possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505665
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  • 6
    Electronic Resource
    Electronic Resource
    Increased excretion of harman by alcoholics depends on events of their life history and the state of the liver (1985)
    Springer
    Psychopharmacology 87 (1985), S. 64-68 
    Details
    ISSN: 1432-2072
    Keywords: Alcoholics ; Harman ; Trace amines ; β-carbolines ; Liver histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Based on the hypothesis of a relationship between the concentration of trace amines like tetrahydroisoquinolines (TIQ's) and β-carbolines (BC's) in the brain and an increased voluntary ingestion of ethanol, the concentrations of ethanol, acetaldehyde and harman (a β-carboline) were examined in a group of 20 alcoholics. The patients excreted a higher amount of harman into the urine than non-alcoholics on the day of admission (harman-1) as well as at the end of the detoxication period, 14 days later (harman-14). Certain factors were related to the increased excretion of harman by alcoholics: The younger the patient when he/she consumed ethanol for the first time, the higher the concentration of acetaldehyde in the blood and the amount of harman (harman-14) excreted in the urine. Furthermore, the younger the patient when he/she was intoxicated with ethanol for the first time the higher the amount of harman (harman-14) in the urine. Patients with first grade relatives who were alcoholics excreted more harman (harman-14) than those without such relatives. The following variables were not related to harman-14: The average amount of ethanol consumed daily during the 6 months prior to admission, the presence of signs of intoxication and symptoms of withdrawal at admission to hospital, and the consumption of other psychotropic substances. A negative correlation was found between the state of the liver, as assessed by liver histology and γ-glutamate transferase (γ-GT) levels, and the concentration of harman in the urine. Thus, some events in the patient's history as well as the state of the liver are important for the increased excretion of harman into urine of alcoholics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431780
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation and characterization of the human pulmonary surfactant apoprotein gene (1985)
    [s.l.] : Nature Publishing Group
    Nature 317 (1985), S. 361-363 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently we isolated a full-length cDNA encoding the canine 32K PSAP8; we used this cDNA in reduced stringency hybridization conditions to screen a human genomic library constructed in bacteriophage Charon 28 (Fig. 1 legend). One hybridizing clone was chosen as the most likely candidate for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/317361a0
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  • 8
    Electronic Resource
    Electronic Resource
    The c- erb -A protein is a high-affinity receptor for thyroid hormone (1986)
    [s.l.] : Nature Publishing Group
    Nature 324 (1986), S. 635-640 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/324635a0
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  • 9
    Electronic Resource
    Electronic Resource
    Protein encoded by v- erbA functions as a thyroid-hormone receptor antagonist (1989)
    [s.l.] : Nature Publishing Group
    Nature 339 (1989), S. 593-597 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive represser and, when ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/339593a0
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  • 10
    Electronic Resource
    Electronic Resource
    Oviposition-deterring pheromone inRhagoletis cerasi L.: Purification and determination of the chemical constitution (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 157-164 
    Details
    ISSN: 1420-9071
    Keywords: Tephritidae ; Rhagoletis cerasi L ; oviposition-deterring pheromone ; constitution ; purification ; electrophysiology ; contactchemoreceptors ; oviposition behavior ; fast atom bombardment mass spectrometry ; two-dimensional mass spectrometry ; gas chromatography ; mass spectrometry ; 1H-NMR spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An oviposition-deterring pheromone (ODP) of the European cherry fruit flyRhagoletis cerasi L. was isolated from faeces using cellulose and several reverse phase TLC and HPLC procedures. The biological activity was evaluated by means of behavior tests and by electrophysiological recordings from tarsal contact chemoreceptors. The compound was structurally characterized as a N[15(β-glucopyranosyl)oxy-8-hydroxypalmitoyl]-taurine by spectroscopic means. The configurations of C-8 and C-15 of the fatty acid constituent remain to be established by synthetic work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01942834
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