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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 267-279 
    ISSN: 1432-1912
    Keywords: Probenecid ; Cardiac Glykosides ; Distribution ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Distribution studies have been performed on mice with tritium labelled Digitoxin, Digoxin and Ouabain. Contrary to many other species Digitoxin does not lead to an accumulation of radioactivity in the mouse organs. Neither the liver, nor the muscle, nor the kidney concentrations ever reached plasma radioactivity levels; the highest organ concentrations in steady state were found in the liver,and attained between 40 and 50% of plasma radioactivity concentrations. Radiochromatographic controls of these experiments in the liver, bile and plasma showed that Digitoxin is metabolized to a very small extent only and is especially not subject to 12-β-hydroxylation: no Digoxin is demonstrable in liver, bile, plasma, and urine of the mouse following Digitoxin administration. Unlike with Digitoxin is the concentration of Digoxin and Ouabain in the mouse liver very effective. Liver radioactivity after 3H-Digoxin administration is found mostly to be 2–3 fold above plasma level concentrations whereas Ouabain—not metabolized in the mouse—may reach liver concentrations up to 35 times the plasma level. Radioactivity in bile reflects this behaviour: Ouabain bile levels reach the highest values (up to 200 fold) whereas Digitoxin never exceeds plasma radioactivity. When Probenecid was given together with the cardiac glykosides, Digitoxin plasma radioactivity fell to about half of the control values with a slight rise in liver and muscle concentrations. With Digoxin and even more with Ouabain Probenecid inhibited their accumulation in the liver leading to a redistribution into the plasma and muscles with subsequent higher muscle concentrations. The general Probenecid effect was to level out concentration gradients mostly pronounced in the Ouabain experiments where also the effect was achieved with the lowest Probenecid dose (20 mg/kg). A satisfactory explanation for this effet is not yet possible.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Infection 7 (1979), S. S151 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A report is given on findings with cefoxitin in the treatment of urinary tract infections, which are frequently encountered after gynaecological operations such as abdominal or vaginal hysterectomy, colporrhaphy and caesarian section. At the end of the ten day treatment with cefoxitin the patients, with two exceptions, were considered cured. Local and general tolerance could be described as good. The only adverse effect was diarrhoea which manifested itself after a treatment period of ten days or more. In the second section treatment of pyometra with local irrigations of cefoxitin is reported. The pyometra, caused byEscherichia coli, appeared at first to be a purulent cervicitis, repeated pathological swabs being taken. After several irrigations, each with 2 g of cefoxitin, the control cervical canal swab was sterile and the cytological smear clear. Simultaneously administered systemic treatment with cefoxitin would seem to be less important.
    Notes: Zusammenfassung Es wird über die Erfahrungen mit der Anwendung von Cefoxitin bei Harnwegsinfekten berichtet, wie sie häufig nach gynäkologischen Operationen, wie abdominalen oder vaginalen Hysterektomien, Kolporrhaphien, Sectio caesarea, auftreten. Im Anschluß an die meist zehn Tage dauernde Therapie mit Cefoxitin waren die Patientinnen, mit zwei Ausnahmen, als geheilt anzusehen. Die lokale und die allgemeine Verträglichkeit konnten als gut bezeichnet werden. Als bisher einzige Nebenwirkung trat eine Diarrhöe auf, welche nach einer mehr als zehn Tage dauernden Therapie bemerkt wurde. Im zweiten Abschnitt wird über die Behandlung einer Pyometra mit lokalen Spülungen mit Cefoxitin berichtet. Die durchEscherichia coli hervorgerufene Pyometra, welche zunächst nur als eitrige Zervizitis imponierte, war die Ursache für wiederholte pathologische Abstriche gewesen. Nach mehrmaliger Spülung mit je 2 g Cefoxitin war der Kontroll-Abstrich steril und der zytologische Abstrich einwandfrei. Eine gleichzeitig durchgeführte systemische Therapie mit Cefoxitin scheint dabei von untergeordneter Bedeutung gewesen zu sein.
    Type of Medium: Electronic Resource
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