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  • 1
    Electronic Resource
    Electronic Resource
    Alkylating properties of phosphate esters. 1. Oxygen .fwdarw. nitrogen methyl transfer in dimethyl (2-pyridylmethyl) phosphate (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 265-267 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00352a033
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  • 2
    Electronic Resource
    Electronic Resource
    Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. XXV. Carbon-13 nuclear magnetic resonance spectral analysis of tobramycin and related antibiotics (1974)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 96 (1974), S. 3300-3305 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00817a045
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  • 3
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    Messias und Sündenvergebung in Jesaja 53-Targum (1972)
    Leiden : Periodicals Archive Online (PAO)
    Journal for the Study of Judaism in the Persian, Hellenistic, and Roman Period. 3 (1972) 117-148 
    Details
    ISSN: 0047-2212
    Topics: History , Theology and Religious Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:v021-1972-003-00-000008
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  • 4
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    Kearns, R., "Das Traditionsgefüge um den Menschensohn. Ursprüngliche Gestalt und älteste Veränderung im Urchristentum" (Book Review) (1989)
    Leiden : Periodicals Archive Online (PAO)
    Journal for the Study of Judaism in the Persian, Hellenistic, and Roman Period. 20 (1989) 238-240 
    Details
    ISSN: 0047-2212
    Topics: History , Theology and Religious Studies
    Notes: Reviews
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:v021-1989-020-00-000031
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  • 5
    Electronic Resource
    Electronic Resource
    Isomerism in parabutylchloral; x-ray crystallographic determinations of 2,4,6-tris(1′,1′,2′-trichloropropyl)-1,3,5-trioxanes (1985)
    Springer
    Journal of chemical crystallography 15 (1985), S. 333-349 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract α-Parabutylchloral (2,4,6-tris(1′,1′,2′-trichloropropyl)-1,3,5-trioxane, C12H15Cl9O3) crystallizes in the orthorhombic space groupP212121 (No. 19) witha=12.165(6),b=9.964(5),c=17.433(9) Å,Z=4. The finalR value is 0.043 for 1667 observed reflections.β-Parabutylchloral crystallizes in the orthorhombic space groupPna21 (No. 33), witha=12.387(6),b=10.488(5),c=16.605(8) Å,Z=4. The finalR value is 0.047 for 1417 observed reflections. Unlike the geometric isomersα- andβ-parachloral (CCl3CHO)3 which exist in boat andcis,cis-chair conformations, theα- andβ-forms of parabutylchloral (CH3CHClCCl2CHO)3 are now shown by X-ray crystallography not to be geometric isomers. Both forms exist incis,cis-chair conformations and the isomerism arises from the chirality of the side chains at theβ-carbon atoms. In theα-form only two of the side chains have the same chirality, but in theβ-form the chirality at all theβ-carbon atoms is the same. The X-ray results are supplemented by1H and13C nuclear magnetic resonance spectroscopy and by mass spectrometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01160726
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  • 6
    Electronic Resource
    Electronic Resource
    Erythropoietin und Hypertonie (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 914-919 
    Details
    ISSN: 1432-1440
    Keywords: Erythropoietin ; Hypertension ; Erythropoietin ; Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirksamkeit von rekombinantem humanem Erythropoietin (rhEpo) bei der Korrektur der Anämie des terminal niereninsuffizienten dialysepflichtigen Patienten ist in mehreren Studien belegt. Eine deutliche Verbesserung der physischen Leistungsfähigkeit konnte durch ergometrische Untersuchungen dokumentiert werden. Neben seltenen Shunt-Thrombosen ist die einzige relevante unerwünschte Wirkung von rhEpo die Entwicklung oder Aggravierung einer Hypertonie bei etwa 30% der behandelten Patienten. Bei ca. 2% der Patienten kam es zur hypertensiven Enzephalopathie mit zentralnervöser Symptomatik. Als Ursache für diese Hypertonie-Entwicklung ist ein Anstieg des peripheren Widerstands anzunehmen. Belege dafür sind Messungen des regionalen Blutflusses mit Plethysmographie vor und nach Anämie-Korrektur mit rhEpo. Ursache für den Widerstandsanstieg wiederum dürfte eine Zunahme der Vollblutviskosität und eine Abnahme der peripheren hypoxiebedingten Vasodilatation sein. Zur Prävention der hypertensiven Komplikationen bei rhEpo-Therapie werden eine langsame Hämatokrit-Korrektur über 12–16 Wochen und eine Begrenzung des Ziel-Hämatokrits auf 30–35 Vol. % bei strikter Blutdruck- und Volumenkontrolle empfohlen.
    Notes: Summary Recombinant human erythropoietin (rhEpo) has been demonstrated in several studies to be effective in correcting the anemia of regular dialysis patients. This was accompanied by a significant improvement of the physical work capacity shown by exercise testing. The main side effect of rhEpo treatment has been the development or aggravation of hypertension in approximately 30% of the treated patients. In 2% hypertensive encephalopathy and convulsions occured. Data obtained by measurements of regional blood flow indicate the peripheral resistance did increase probably due to rise of blood viscosity and reversal of preexisting hypoxic vasodilatation. To avoid hypertensive complications anemia should be corrected slowly over a period of 12–16 weeks. Target hematocrit should not exceed 30–35 vol. %. Blood pressure and volume status should be monitored closely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728954
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  • 7
    Electronic Resource
    Electronic Resource
    Effekte einer Captopriltherapie auf die Natrium- und Wasserausscheidung bei Patienten mit Leberzirrhose und Aszites (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 774-783 
    Details
    ISSN: 1432-1440
    Keywords: Liver cirrhosis ; Ascites ; Renin-angictensin-aldosterone-system ; Renal functional impairment ; Sodium excretion ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ascites in patients with cirrhosis of the liver frequently is refractory to diuretic treatment. It was postulated that vasoconstriction of the renal cortex, mediated by activation of the renin-angiotensin-aldosterone-system (RAAS), may be one course of the disturbed sodium- and water-excretion in these patients. We therefore investigated in 14 cirrhotic patients with ascites under constant diuretic treatment the effects of low-dose captopril therapy on urinary sodium- and potassium-excretion, body weight, abdominal girth, serum-sodium,-potassium, creatinine-clearance, plasma-renin-activity (PRA), plasma-aldosterone (PA) and mean arterial pressure (MAP). After a control period of 4 days the patients received 2 × 6.25 mg/d captopril for 5 days and 4 × 6.25 mg/d for further 5 days. Treatment was followed by a second control period without captopril. PRA increased significantly after 2 days of captopril treatment. 2 × 6.25 mg/d captopril induced a significant increase in sodium excretion and a significant decrease of body weight. MAP decreased slightly but significantly without clinical signs of hypotension. 4 × 6.25 mg/d captopril resulted in a further reduction of body weight and a further enhancement of sodium excretion. Three days after withdrawal of captopril sodium output was significantly reduced again. Conclusion: In cirrhotic patients low-dose captopril seems to be efficient in the treatment of ascites resistant to diuretics without causing major side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745350
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  • 8
    Electronic Resource
    Electronic Resource
    Extrarenal actions of aldosterone antagonists in guinea pigs (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 9-18 
    Details
    ISSN: 1432-1912
    Keywords: Aldosterone Antagonists ; β-Methyl-Digoxin ; Guinea Pigs ; Potassium ; Cardiac Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of aldosterone antagonists on the cardiotoxicity of β-methyl-digoxin in guinea pigs were investigated in vivo and in vitro. 1. Three days of pretreatment with spironolactone influenced neither plasma concentrations, urinary output and tissue distribution of radioactivity after intravenous injection of β-methyl-digoxin nor the pattern of lipid soluble metabolites in the urine. 2. Spironolactone injected intraduodenally 1 h before the infusion of β-methyl-digoxin decreased the cardiotoxicity of the latter if hypokalemia was reduced or prevented by giving 0.4–1.0 mEq/kg KCl 1 h before β-methyl-digoxin. 3. Three days of pretreatment with canrenoate-K decreased the cardiotoxicity of β-methyl-digoxin in vivo without the administration of KCl. 4. Isolated hearts from guinea pigs pretreated with canrenoate-K for 3 days tolerated the perfusion with toxic concentrations of β-methyl-digoxin better than those from controls although the rate of potassium extrusion from the heart was not decreased. 5. The addition of canrenone to the fluid perfusing isolated hearts decreased the potassium extrusion produced by and the toxicity of β-methyl-digoxin. The results suggest that the decreased glycoside toxicity is due to the stimulation of inward transport of potassium by aldosterone-antagonists described in the preceding paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502063
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  • 9
    Electronic Resource
    Electronic Resource
    β-Methyl-digoxin (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 9-14 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac Glycosides ; Distribution ; Guinea Pigs ; Protein Binding ; Therapeutic Ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In guinea pigs under urethane anaesthesia the concentrations of radioactivity in the plasma, the liver and the heart and the protein binding of radioactivity were measured 1 h after the intravenous injection of 0.2 μmoles/kg β-methyldigoxin or digoxin. The distribution coefficients were calculated between the concentrations in the plasma water and the tissues. Apart from a slightly higher distribution coefficient for β-methyl-digoxin than for digoxin between liver and plasma water there was no significant difference between the two glycosides. In guinea pigs under barbital anaesthesia, cardiac failure was produced by additional doses of barbital-Na. Bemegride was given to counteract the effects of barbital on the vasomotor centre. β-Methyl-digoxin and digoxin were infused until cardiac arrest. For each animal the doses were calculated which led to an increase in cardiac performance by 50 g · cm/sec, arrhythmia, ventricular fibrillation or cardiac arrest. The therapeutic range was calculated from the doses producing arrhythmias and those increasing cardiac performance by 50 g · cm/sec (“therapeutic” dose). There was no difference between the “therapeutic” and toxic doses and the therapeutic ratios of β-methyl-digoxin and digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647399
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  • 10
    Electronic Resource
    Electronic Resource
    Die Behandlung gynäkologischer Karzinome mit Iridium-192-Kurzzeit-Afterloading (1987)
    Springer
    Archives of gynecology and obstetrics 242 (1987), S. 444-446 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die AL-Bestrahlungstechnik bei 71 Patientinnen wies eine geringe Nebenwirkungsrate auf, es gabkeine strahlungsbedingten Fisteln, die Tumorprogredienzrate war günstig. Wegen der kurzen Behandlungsdauer von 10–15 min konnte die Bestrahlungenambulant ohne Anästhesie durchgeführt werden, es gab keine Embolien. Frühkomplikationen bestanden zumeist aus Blasenstörungen nach Einlage der intravesicalen Meßsonde. Selten gab es Darmblutungen oder Diarrhoen. Nach unseren Ergebnissen ist die Afterloading-Methode der herkömmlichen Radium-Bestrahlung deutlich überlegen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01783204
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