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  • 11
    Electronic Resource
    Electronic Resource
    A double-blind study on the effect of discontinuation of gold therapy in patients with rheumatoid arthritis (1986)
    Springer
    Clinical rheumatology 5 (1986), S. 56-61 
    Details
    ISSN: 1434-9949
    Keywords: Chrysotherapy ; Serum Concentrations ; Controlled Study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the benefit of further gold treatment of rheumatoid arthritis (RA) patients who had already received more than 6 g of this metal, 24 such patients were included in a double-blind trial. Besides this “gold group” comprising 11 patients who received gold (Auromyose®) in the same dosage schedule as before the study, the trial included a “placebo group” comprising 13 patients who received gold in a suspension diluted 1/100. In either group clinical, laboratory, and radiological data did not differ after 6 and 24 months in relation to the results at entry except for the serum gold concentrations, which were lower in the placebo group. We conclude that discontinuation of the treatment in RA patients who have received more than 6 g gold is not harmful to the patients for at least two years after withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030968
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  • 12
    Electronic Resource
    Electronic Resource
    Comparison of the automated Bactec NR-660 with a conventional blood culture system (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 724-726 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Bactec NR-660 blood culturing system was compared with a conventional system using 347 consecutively obtained clinical blood samples tested simultaneously. Of 46 clinically relevant isolates, 12 were detected by the conventional system only, 5 by Bactec only and 29 by both methods (0.05〈p〈0.10). The difference could not be explained by the results of additional in vitro tests. Of 12 isolates considered contaminants, 7 were isolated in the conventional system only, 2 in the Bactec system only and 3 in both systems (0.05〈p〈0.10). The two systems were approximately equal in speed of detection. A high rate of false indications of growth in the Bactec system could be reduced by applying different CO2 cut-off values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963760
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  • 13
    Electronic Resource
    Electronic Resource
    Comparison of test systems for recognition of methicillin resistance inStaphylococcus aureus (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 968-973 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methicillin resistance inStaphylococcus aureus can be difficult to recognize because it may be expressed in only a small portion of the population. The optimal reference to use in comparing different test systems is controversial. In this study MIC values of ≤ 4 mg/l as observed in two experiments, each including 12 test systems (24 h incubation), were used to define strains as methicillin-susceptible. This strict standard was used to compare 24 quantitative and 36 agar diffusion test systems applied to 61 strains. These test systems included six agar media (Mueller Hinton, Oxoid and BBL; and Iso-Sensitest, Oxoid; all with and without 5% NaCl), three broth media of the same type, two incubation temperatures (30 °C and 37 °C), two incubation times (24 h and 48 h) and five disc types [methicillin 10µg (M 10), three types of methicillin 5µg (M 5) and oxacillin 1µg (O 1)]. Standardized high inocula were used. It was concluded that 24 h incubation is preferable to 48 h; at 24 h, differences in recognition of methicillin-resistantStaphylococcus aureus (MRSA) among 12 quantitative test systems were not statistically significant; incubation at 30 °C gave slighty better results in difussion tests. Reproducibility of quantitative data (Friedman test) was better on Mueller Hinton media (p〈0.001) than on Iso-Sensitest medium in both dilution and agar diffusion test systems. The rank order of discs was M 5〉M 10〉O 1 (p〈0.001). An inhibition zone of 〈13 mm with a M 5µg (BBL) disc should be interpreted as MRSA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967567
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  • 14
    Electronic Resource
    Electronic Resource
    Über die Ionenbeweglichkeit (1935)
    Springer
    The European physical journal 97 (1935), S. 681-689 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Es wird der Born-Effekt der Ionenbeweglichkeit, der seinen Grund in der Mitbewegung der Dipole des Lösungsmittels hat, genau berechnet. 1. Lösung der Gleichungen im Falle unendlicher Verdünnung. 2. Ausdehnung auf den Fall nicht unendlicher Verdünnung. Die Konzentrationsabhängigkeit ist in erster Näherung proportional c und nicht √c.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01342421
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  • 15
    Electronic Resource
    Electronic Resource
    Der Born-Effekt der Ionenbeweglichkeit. Die Waldensche Regel (1937)
    Springer
    The European physical journal 104 (1937), S. 100-112 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung 1. Nachdem ein schon früher besprochener Born-Effekt (in dieser Arbeit Born-Effekt erster Art genannt) eingehend diskutiert worden ist, wird auf einen Born-Effekt zweiter Art hingewiesen, an dem Born damals vorbeigegangen ist, und der Von einer unsymmetrischen Potentialverteilung um das Ion bedingt wird. — 2. Die erhaltene Formel zeigt sich qualitativ in guter Übereinstimmung mit den bei der Waldenschen Regel experimentell bestimmten Abweichungen. Für eine quantitative Prüfung sind einige der in der Formel auftretenden Größen leider nicht genügend bekannt. — 3. Der Born-Effekt zweiter Art bedingt eine Korrektur in der Onsagerschen Leitfähigkeitsformel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01337897
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  • 16
    Electronic Resource
    Electronic Resource
    Clinical evaluation of pneumococcal meningitis in adults over a twelve-year period (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 695-700 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A retrospective study was performed to review the clinical features and outcome of 39 episodes of pneumococcal meningitis in 36 adult patients over a 12-year period. Overall mortality was 33.3%. Only a few of the deaths were directly related to the central nervous system disease and most of them were due to cardiorespiratory failure. Univariate analysis showed that death was more likely to occur in patients with advanced age, an absence of neck stiffness, a high pulse rate, an associated pneumonia, internal complications, or a long duration of the disease (〉7 days) before treatment was started. Patients who died had a higher erythrocyte sedimentation rate and serum bilirubin level and a lower serum sodium level than those who survived. Discriminant analysis showed the development of internal complications to be the strongest predictive factor of a poor outcome of illness. Two other important predictors of a poor outcome were the absence of neck stiffness and associated pneumonia. The history of a skull fracture or head surgery was significantly correlated with a better than average prognosis. The incidence of sequelae in survivors at the time of discharge amounted to 72%. None of the clinical features were significantly correlated with the development of sequelae, except a higher cerebrospinal fluid protein content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963754
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  • 17
    Electronic Resource
    Electronic Resource
    Interconversion of F430 derivatives of methanogenic bacteria (1988)
    Springer
    Antonie van Leeuwenhoek 54 (1988), S. 207-220 
    Details
    ISSN: 1572-9699
    Keywords: Factor F430, Ni(II) tetrapyrrole ; methylcoenzyme M reduction ; methanogenesis ; Methanosarcina barkeri ; Methanobacterium thermoautotrophicum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract F430 is the prosthetic group of the methylcoenzyme M reductase of methanogenic bacteria. The compound isolated from Methanosarcina barkeri appears to be identical to the one obtained from the only distinctly related Methanobacterium thermoautotrophicum. F430 is thermolabile and in the presence of acetonitrile or C10 in4 sup- two epimerization products are obtained upon heating; in the absence of these compounds F430 is oxidized to 12, 13-didehydro-F430. The latter is stereoselectively reduced under H2 atmosphere to F430 by cell-free extracts of M. barkeri or M. thermoautotrophicum. H2 may be replaced by the reduced methanogenic electron carrier coenzyme F420.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443579
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  • 18
    Electronic Resource
    Electronic Resource
    Purification and characterization of the NADP-dependent glutamate dehydrogenase from Bacillus fastidiosus (1989)
    Springer
    Antonie van Leeuwenhoek 55 (1989), S. 303-311 
    Details
    ISSN: 1572-9699
    Keywords: Bacillus fastidiosus ; glutamate dehydrogenase ; nitrogen metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Ammonia assimilation in Bacillus fastidiosus proceeds via the NADP-dependent glutamate dehydrogenase. The enzyme, purified to homogeneity, is composed of identical subunits with a molecular weight of about 48 000 dalton. Presumably the enzyme is a hexamer. The enzyme is specific for NADP (H). The pH optima for the amination and deamination reactions are 7.7 and 8.6, respectively. The temperature optimum is 60°C. Furthermore, temperature stability and apparent Km values for substrates of both the amination and deamination reactions were determined. Several metabolites were tested for their effect on the enzyme activity. Only malate and fumarate showed some inhibitory effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398509
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