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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 5 (1987), S. 325-365 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 67 (1989), S. 1229-1235 
    ISSN: 1432-1440
    Keywords: PGE1, PGE2, PGI2, Iloprost ; cAMP ; Normal liver ; Hepatocellular cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The binding of prostaglandin (PG) E1 and Iloprost, a chemically stable PGI2-analogue, to purified plasma cell membranes (LPZM) from liver tissue samples obtained at surgery revealed heterogeneity of the binding sites identifying high and low affinity subpopulations. In contrast to these findings only high affinity binding sites were characterized for PGE2. Displacement studies exhibited the highest competition for the PGE1-sites by PGE1 and subsequently by PGE2, Iloprost, PGD2 and PGF2 α. The binding of PGE2 to the hepatic receptor could be best displaced by PGE2 and subsequently by PGE1 and Iloprost, PGD2 and PGF2 α. In addition, PGE1, PGE2 and Iloprost enhanced cAMP-production dose-dependently over baseline. Clinical studies revealed a remarkably lower binding capacity for PGE1 in hepatocellular cancer tissue than in noral liver parenchyma. The different binding behaviour of PGE1 (Iloprost) and PGE2 for the first time provides evidence that PGE1 and PGI2 like at platelet membranes occupate the same receptor also at human LPZM. Since a reasonable number of binding sites for these substances and an enhanced cAMP-production were shown in the liver, the study indicates a regulatory role of PGs in hepatic function.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0584
    Keywords: HLA-class II ; Hematopoietic progenitor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A panel of alloindifferent monoclonal antibodies (MAB's) was used in complement-dependent lysis to characterize human myeloid, erythroid and multipotential progenitors (CFU-GM, BFU-E, CFU-GEMM) for their expression of MHC class II HLA-DR, -DP, and -DQ products. 7–16 donors were tested in each system. MAB Tü 34, detecting DR products, caused reduction of CFU-GM by a mean of 89%, whereas BFU-E and CFU-GEMM were reduced by 67% and 66% respectively. 35% of CFU-GM, 27% of BFU-E and 32% of CFU-GEMM were lysed by MAB B7/21, recognizing HLA-DP determinants, while Tü 22, binding HLA-DQ antigens, lysed 32% only of CFU-GM and did not lyse the other progenitors. Employing the “broad” MAB Tü 39, which binds at least DR and DP, inhibition of colony formation by CFU-GM was generally greater than that caused by Tü 34 alone or even by combinations of Tü 34, Tü 22, and B7/21. This suggests that there may be a subset of DR−, DP−, DQ− hematopoietic progenitors, which nonetheless bind MAB Tü 39, previously proposed as a candidate for the recognition of novel class II antigens.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 42 (1989), S. 71-80 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 284-285 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Bone marrow transplantation ; Anti-CMV hypergammaglobulin ; Azyklovir ; Conditioning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow transplantation was performed between IV/82 and X/85 in 64 patients with acute leukemia (n=36), chronic myelogenous leukemia (CML;n=13), severe aplastic anemia (n=12), and neuroblastoma stage IV (n=3). Of these patients 57 received allogeneic marrow from HLA-ABCDR identical, MLC-negative sibling donors. Six transplants were performed with syngenic marrow and one with autologous marrow. Of the 64 patients 48 survived 40-1,250 days after transplantation, resulting in a survival rate (SR) of 75% and a survival probability (SP) of 71%. Of the 36 patients suffering from acute leukemia (SR=64%, SP=51%), patients with acute myelogenous leukemia (AML) in first complete remission (n=11; SR=81%, SP=76%), as well as patients with acute lymphatic leukemia (ALL) in 1st to 4th complete remission at the time of transplantation (n=14; SR=81%, SP=76%) show a favorable prognosis. A poor survival rate was seen for patients with AML when transplanted in second or partial remission (1/5; SR=20%), as well as for patients suffering from ALL and transplanted during relapse or partial remission (1/6; SR=16%). Of 13 patients suffering from CML 12 survived the transplantation free of relapse (SR=93%, SP=92%), and one patient died from varicella zoster pneumonia. Of the transplanted patients with severe aplastic anemia, 12 of 13 are surviving with complete hematologic reconstitution; one patient, however, died on day 10 from a sepsis. In our patient group, the SR as well as the SP has been improved through changes in the irradiation protocol concomitant with prophylactic application of anti-CMV hypergammaglobulin, as well as through additional oral medication of Azyklovir. The 41 patients (BMT No. 7–47) with total body irradiation at one time-show an SR of 44% and an SP of 41%. The following 46 patients (BMT No. 48–93) have reached an SR of 83% and an SP of 74% under the regimen of fractionated total body irradiation, plus prophylaxis with anti-CMV hypergammaglobulin and Azyklovir. Within this group, no fatal CMV pneumonia was encountered as opposed to six patients lost from CMV pneumonia in the first group.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Marine sediment location spread over a wide range of environments contain evidence of anoxic intervals dated early Late Cretaceous. In the north and south deep Atlantic deposition of anoxic layers followed a widespread sedimentary hiatus of Middle Cenomanian age. In the eastern-central parts of the Atlantic (Angola and Cape Verde basins) rythmic deposition of anoxic layers commenced in the Latermost Cenomanian and lasted as late as the Santonian. In the rest of the deep north Atlantic on the contrary anoxia duration was probably limited to the Cenomanian-Turonian boundary or thereabout. Late Cretaceous anoxic layer is not yet recorded south of the Walvis-Rio Grande Rises in the South Atlantic. In a number of locations in marginal and epicontinental seas in America, Africa and Europe previously related to the Tethys a few anoxic layers dated Cenomanian-Turonian are intercalated within thick oxic series. Coniacian to Santonian anoxic layers are limited to small areas in epeiric and marginal domains in the southern Alps, North Africa, Israel, North America (Santonian in the Western Interior) and (?) Australia all with no clear link with any ocean-wide event of early Senonian age. Rythmical alternation of oxic/anoxic layers helps to document the emplacement of sediment and disposition of anaerobic water masses. Development of anoxia at about the Cenomanian-Turonian boundary induced abnormal concentration of trace metals and a partial renewal of the marine fauna. To understand the relationship between a number of factors such as sea-level changes, climates, terrestrial influences, biogenic fertility, sedimentation rates, etc., is essential to explain of the very peculiar anoxic global event of early Late Cretaceous age.
    Abstract: Résumé Le Crétacé supérieur a été une période favorable au développement de milieux anoxiques depuis les régions profondes de l'Atlantique et de la Tethys occidentale jusqu'aux mers épicontinentales adjacentes. Après une lacune sédimentaire datée du Cénomanien moyen et générale dans l'Atlantique, l'anaérobiose a duré de manière épisodique depuis le Cénomanien terminal jusqu'au Santonien dans la partie orientale de l'océan (bassins du Cap Vert et de l'Angola). Ailleurs, elle a été restreinte dans le temps aux alentours de la limite Cénomanien-Turonien, sauf au Sud de la ride Rio-Grande Walvis où elle n'a pas été reconnue encore par forage. Plusieurs couches de sédiments anoxiques présentes dans des séries plus ou moins épaisses, déposées en milieu aérobie sont connues également à la limite Cénomanien-Turonien, dans les mers épicontinentales fossiles d'Amérique, d'Afrique et d'Europe. Il semble donc que l'événement anoxique commençant à l'extrême fin du Cénomanien ait un caractère global. Des dépôts anoxiques d'âge Sénonien inférieur ont été repérés aussi sur des surfaces limitées dans les Alpes méridionales, en Afrique du Nord, en Amérique du Nord (Santonien du Western Interior Basin), en Israel et peut-être en Australie. L'êtude des alternances de couches aérobies et anaérobies de différents types permet la reconstitution de la disposition des masses d'eau anoxiques au moment du dépôt. L'événement anoxique du Cénomanien-Turonien a déterminé diverses anomalies géochimiques dans les sédiments ainsi qu'un renouvellement d'une partie de la faune benthique et planctonique. La compréhension des relations mutuelles complexes entre les différents facteurs qui régissent les caractéristiques des milieux océaniques est essentielle pour interpréter un événement aussi singulier que l'anoxie globale datée des alentours de la limite Cénomanien-Turonien.
    Notes: Zusammenfassung Während der oberen Kreide entstanden bevorzugt anoxische Bedingungen, sowohl in den tiefen Gebieten des Atlantiks und der westlichen Tethys, als auch in den naheliegenden epikontinentalen Meeren. Nach der im ganzen Atlantik vorkommenden sedimentären Lücke des mittleren Cenomans, dauerte die Anaerobiose, mit mehreren Unterbrechungen, vom obersten Cenoman bis zum Santon, jedenfalls im östlichen Teil des Ozeans (Cape-Verde und Angola Becken). Andernorts war sie zeitlich auf den Grenzbereich zwischen Cenoman und Turon beschränkt, außer im Süden des Rio Grande-Walvis Rückens, wo sie durch Bohrungen noch nicht festgestellt wurde. In den epikontinentalen Teilen des Paläo-ozeans Amerikas, Afrikas u. Europas kennt man auch mehrere anoxische Sedimentlagen, die in mächtige oxische Ablagerungen eingebettet sind. Also scheint das im obersten Cenoman beginnende anoxische Ereignis eine globale Bedeutung zu besitzen. Kleinere Flächen von anoxischen Ablagerungen des unteren Senons wurden auch in den südlichen Alpen, in Nordafrika, in Israel und vielleicht in Australien entdeckt. Sie stehen aber in keinem weltweiten Zusammenhang. Aus der Untersuchung der Wechsellagerung der oxischen und anoxischen Schichten läßt sich die Lage der oxischen Wassermassen zur Zeit der Ablagerung bestimmen. Das anoxische Cenoman-Turon Ereignis bewirkte verschiedene geochemische Unregelmäßigkeiten in den Sedimenten und hatte gleichfalls eine partielle Erneuerung der gesamten Fauna zur Folge. Um ein solch seltsames Ereignis, wie diese globale Anoxie um die Wende Cenoman-Turon zu verstehen, ist es nötig, das Zusammenwirken verschiedener Faktoren, wie Meeresspiegel- und Klimaschwankungen, kontinentale Einflüsse, organische Produktivität, Sedimentationsraten usw. zu erfassen.
    Type of Medium: Electronic Resource
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  • 8
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    Unknown
    Berlin, etc. : Periodicals Archive Online (PAO)
    Philologus. 43 (1884) 358 
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  • 9
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    Unknown
    Berlin, etc. : Periodicals Archive Online (PAO)
    Philologus. 45 (1886) 718 
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  • 10
    facet.materialart.
    Unknown
    Berlin, etc. : Periodicals Archive Online (PAO)
    Philologus. 47 (1889) 762 
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