ISSN:
1432-1041
Keywords:
co-dergocrine
;
platelet function
;
platelet proteins
;
prostaglandins
;
aggregation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In 20 healthy volunteers double-blind randomized study was done to examine the effect of codergocrine (Hydergin) on platelet function. All the volunteers were pretreated with 3×1 placebo for 1 week, followed by the randomized study in which 10 volunteers each received drug or placebo for 6 weeks. Various platelet function parameters, such as the peripheral platelet count, plasma thromboxane B2, platelet sensitivity to the antigaggregatory prostaglandins PGI2, PGE1 and PGD2, ADP-in-duced aggregation, collagen-induced aggregation, the WU-test, the platelet proteins platelet factor 4 and β-thromboglobulin, malondialdehyde, circulating endothelial cells and the intracellular c-AMP level in platelets were examined. Treatment with co-dergocrine decreased platelet activity to a significant extent, as shown by a number of platelet function parameters, such as thromboxane B2, WU-test, β-thromboglobulin, platelet factor 4, malondialdehyde and ADP-induced aggregation. The findings suggest that co-dergocrine might be able to decrease platelet activity and improve interaction with the walls of to a blood-vessel significant degree.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00607922
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