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  • 1
    Electronic Resource
    Electronic Resource
    Isradipine improves platelet function in hypertensives (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 43-46 
    Details
    ISSN: 1432-1041
    Keywords: Isradipine ; hypertension ; platelet function ; prostaglandin system ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of treatment for eight weeks with isradipine 1.25 mg twice daily for 4 weeks and thereafter 2.5 mg twice daily for 4 weeks on ex vivo platelet function was investigated in 10 male hypertensive patients, aged 51 (6.1) y. Systolic and diastolic blood pressure, platelet aggregation in response to ADP, serum thromboxane B2 and β-thromboglobulin levels were significantly decreased at rest before exercise ergometry, during exercise and at rest after exercise. The platelet count, platelet sensitivity and the plasma levels of 6-oxo-prostaglandin F1α were not affected by isradipine. It is concluded that a compound that lowers blood pressure and inhibits platelet activation may be of clinical benefit in the routine treatment of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314918
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enhanced mitotic activity induced by irradiation is abolished by PGI2 pretreatment
    Amsterdam : Elsevier
    Prostaglandins 41 (1991), S. 57-65 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(91)90105-O
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Autologous low-density lipoprotein labelling allows characterization of human atherosclerotic lesions in vivo as to presence of foam cells and endothelial coverage (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 948-951 
    Details
    ISSN: 1619-7089
    Keywords: Autologous low-density lipoprotein labelling ; Iodine-123 ; Iodine-131 ; Foam cells ; Endothelial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The monitoring of local vascular kinetics after injection of autologous radiolabelled low-density lipoprotein (LDL) allows characterization of human atherosclerotic lesions as to the presence of foam cells and the quality of endothelial coverage. The following evidence exists: (1) dynamic imaging reveals two types of visual LDL accumulation in the vascular bed, one increasing, becoming visible sometimes only as late as after 24 h, and the other one appearing very early on, but decreasing with time; (2) the accumulation of iodine-123 LDL or iodine-131 LDL in the vascular bed shows three major types of local kinetic curves, which correlate with scintigraphic findings; (3) the accumulation of radiolabelled LDL in the vascular bed of humans in vivo is similar to its uptake in de- and re-endothelialized vessels of experimental animals using 125I-LDL; (4) morphological control in endarteriectomy samples confirms the hypothesis that this promising new approach may for the first time allow the in vivo monitoring of preclinical lesions in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180413
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Prävalenz des Plasmafaktormangels in der Wiener Bevölkerung (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 779-783 
    Details
    ISSN: 1432-1440
    Keywords: Plasma factor deficiency ; Atherosclerosis ; Prostaglandin system ; Prostacyclin synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A screening investigation for the presence of risk factors for the development of atherosclerosis demonstrates a plasma factor deficiency in 0,8% in the Viennese population. These findings are in agreement with the data of a newborn screening performed earlier. All the persons were clinically healthy. In 4 of them at least 1 family member suffered from the same defect. The pathogenetic relevance of the plasma factor defect for thrombophilia at young age is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726578
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Beneficial effect of PGI2 on circulating endothelial cells (1988)
    Springer
    Basic research in cardiology 83 (1988), S. 597-601 
    Details
    ISSN: 1435-1803
    Keywords: circulatingendothelial cells ; atherosclerosis ; prostaglandinI2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endothelial damage is an early event in atherogenesis. Recent data present evidence that the counting of circulating endothelial cells in human peripheral blood may provide reliable information about endothelial integrity. We therefore assessed the influence of PGI2 on the number of circulating endothelial cells in patients suffering from peripheral vascular disease. As cigarette smokers and patients with hyperlipoproteinemia show an increased number of circulating endothelial cells, they were excluded from this investigation. PGI2 causes a certain drop in circulating endothelial cells. In parallel, a prolongation in platelet half-life can be noted. This is most pronounced at a daily duration of infusion between 4 an 12 h. A shorter duration of PGI2 therapy is less effective in reducing circulating endothelial cells. All of the three different doses used, however, were equally effective. Placebo controls were ineffective. These findings indicate that PGI2 might exert a rather long-lasting beneficial action on endothelial integrity and the hemostatic balance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01906953
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    Paper (German National Licenses)
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