Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    ‘Tear gas’ for the diagnosis of diabetic autonomic neuropathy? (1982)
    Springer
    Diabetologia 23 (1982), S. 288-288 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252861
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prostaglandin E1 increases binding of 123I-low-density lipoprotein to the human liver in vivo (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 515-520 
    Details
    ISSN: 1432-1041
    Keywords: Prostaglandin E1 (PGE1) Hypercholesterolaemia ; low-density lipoprotein (LDL) ; LDL receptor ; human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Previous in vitro radioligand binding data have shown that prostaglandin E1 (PGE1) increases the number and the binding affinity of low-density lipoprotein (LDL) receptors of the human liver. Experimental data in normo- and hypercholesterolaemic rabbits have confirmed these findings, showing a significant increase in LDL-binding to the liver in vivo after prolonged PGE1 therapy. Methods: This study aimed to confirm the experimental and animal data in human in vivo. 123I-LDL binding to the liver was quantified in vivo in patients suffering from peripheral vascular disease, seven of them with heterozygous familial hypercholesterolaemia (HC) and five with normal total plasma cholesterol, after PGE1 administration (5 ng·kg−1·min−1; 6 h daily for 5 days/week for 5 weeks). LDL uptake by the liver was quantified by single photon emission computer tomography (SPECT). Results: The amount of LDL trapped by the liver in normocholesterolaemics (45.6%) was significantly higher than in hypercholesterolaemics (22.0%). PGE1 induced an increase in liver LDL binding, which was more pronounced in HC (+38.2%) than in normocholesterolaemic patients (+8.11%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195940
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Prostaglandin E1 decreases human arterial accumulation of radiolabeled apo B-containing lipoproteins in vivo (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 191-197 
    Details
    ISSN: 1432-1041
    Keywords: Key words Prostaglandin E1; low-density lipoprotein ; cholesterol ; atherosclerosis ; lesional imaging ; arterial apo B-containing lipoprotein influx,
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: An increased apo B-containing lipoprotein influx and cholesterol ester accumulation in arteries are well-known events in human atherogenesis. In vitro and experimental animal studies have provided evidence of a beneficial effect of PGE1 on both vascular apo B-containing lipoprotein accumulation and cholesterol ester content. Methods: We examined the effect of PGE1 (administered via an intravenous portable infusion pump at a rate of 5 ng PGE1 kg−1 ·  min−1 for 5 days a week, 6 h daily, over a total of 5 weeks) in ten patients (eight males, two females) on 123I-apo B-containing lipoprotein accumulation into the large arteries in vivo. Apo B-containing lipoprotein isolation was carried out by immunoaffinity chromatography and radiolabeling with the iodine monochloride method. 123I-apo B-containing lipoprotein accumulation was imaged and quantified by means of special computer software before and after 5 weeks of PGE1 therapy Results: PGE1 led to a significant decrease in maximal arterial apo B-containing lipoprotein retention. The mean decrease in the carotid and femoral arteries in type I lesions amounted to between 16.9% and 30.4%, and in type II lesions between 22.4% and 30.7%, 20 h after injection of radiolabeled apo B-containing lipoprotein. The type of arterial apo B-containing lipoprotein kinetic curves, however, remained unchanged. Conclusion: These findings indicate that PGE1 decreases the apo B-containing lipoprotein influx in the large arteries and the vascular cholesterol content, suggesting that PGE1 may lead to regression of lipid-rich lesions in human in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050273
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Prostaglandin E1 increases binding of 123I-low-density lipoprotein to the human liver in vivo (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 515-520 
    Details
    ISSN: 1432-1041
    Keywords: Key words Prostaglandin E1 (PGE1) Hypercholesterolaemia; low-density lipoprotein (LDL) ; LDL receptor ; human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Previous in vitro radioligand binding data have shown that prostaglandin E1 (PGE1) increases the number and the binding affinity of low-density lipoprotein (LDL) receptors of the human liver. Experimental data in normo- and hypercholesterolaemic rabbits have confirmed these findings, showing a significant increase in LDL-binding to the liver in vivo after prolonged PGE1 therapy. Methods: This study aimed to confirm the experimental and animal data in human in vivo. 123I-LDL binding to the liver was quantified in vivo in patients suffering from peripheral vascular disease, seven of them with heterozygous familial hypercholesterolaemia (HC) and five with normal total plasma cholesterol, after PGE1 administration (5 ng⋅kg−1 ⋅min−1 ; 6 h daily for 5 days/week for 5 weeks). LDL uptake by the liver was quantified by single photon emission computer tomography (SPECT). Results: The amount of LDL trapped by the liver in normocholesterolaemics (45.6%) was significantly higher than in hypercholesterolaemics (22.0%). PGE1 induced an increase in liver LDL binding, which was more pronounced in HC (+ 38.2%) than in normocholesterolaemic patients (+ 8.11%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Behaviour of impotence in type-1 diabetics after 12 months improved metabolic control
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 20 (1984), S. 1491 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(84)90667-8
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Implanted constant basal rate insulin infusion devices for type 1 (Insulin-dependent) diabetic patients (1983)
    Springer
    Diabetologia 25 (1983), S. 78-81 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; implantation ; insulin pump ; basal rate infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multi-phase study was undertaken to compare the metabolic effect on unstable Type 1 diabetic patients of optimized conventional treatment with that of external or implantable insulin delivery devices. External units were programmed to simulate implantable constant basal rate insulin infusion pumps with additional insulin doses given by subcutaneous injection or delivered by the pump. The study was continued using external devices with an optimal, meal-adjusted insulin profile simulating programmable, remote-controlled, implantable devices. Such good metabolic control was achieved using the constant insulin infusion, supplemented by two subcutaneous injections of insulin daily, that it justified the implantation of constant rate pumps in five Type 1 patients. Patients with the implanted devices achieved a near-normal life style, experienced significantly fewer hypoglycaemic reactions and had significantly improved glycosylated haemoglobin A1 and mean blood glucose values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250891
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Differentialdiagnose von Erkrankungen der Achillessehne Ein klinisch-sonographisches Konzept (1996)
    Springer
    Der Radiologe 36 (1996), S. 38-46 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Achillessehne-Ultraschall ; Achillessehne-MRI ; Xanthomatose-Diagnose ; Achillessehne-Pathologie ; Ultraschalldiagnose ; Key words Achilles tendon ultrasonography ; Achilles tendon magnetic resonance imaging ; Achilles tendon pathology ; Xanthomatosis diagnosis ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Ultrasound of the Achilles tendon is a suitable means of differentiating various diseases of the tendon and the surrounding tissue. Different forms of degenerative disease (tendinitis, peritendinitis or bursitis, fibroosteitis, and Haglund's disease) can be discriminated from rheumatic and metabolic diseases. Congenital and developmental abnormalities can also be detected. Tendon degeneration mainly occurs in the ventral part of the medial third of the tendon (“critical zone”). Immature tissue in this area leads to temorary instability of the tendon with a high risk of rupture (”vulnerable phase”). With sonography, lesions of the Achilles tendon are visible early in the course of the disease.
    Notes: Zusammenfassung Die Sonographie der Achillessehne ist im Kontext mit der klinischen Untersuchung ein sehr probates Verfahren zur Differenzierung verschiedener Erkrankungen der Sehne und ihres Gleitlagers hinsichtlich Art und Schweregrad verschiedener Erkrankungen: Unterschiedliche Formen der Degeneration (Tendinose, Peritendinose bzw. Bursitis, Fibroostose und Haglund-Ferse) können von entzündlichen Systemerkrankungen und metabolisch-toxischen Veränderungen abgegrenzt werden. Auch angeborene bzw. entwicklungsbedingte Abnormitäten sind nachweisbar. Vor allem degenerative Veränderungen finden mit besonderer Häufigkeit im ventralen Teil des mittleren Sehnendrittels („kritische Zone“) statt. In Phasen größerer Belastung führen reaktive Umbauvorgänge zu einer passageren Instabilität mit höherem Rupturrisiko („vulnerable Phase“). Da Läsionen der Achillessehne mit modernen sonographischen Techniken sehr frühzeitig nachgewiesen werden können, kommt dieser Methode große diagnostische Bedeutung zu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050037
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Detection of early atherosclerotic lesions in the carotid artery: Experimental and preliminary human data (1997)
    Springer
    The international journal of angiology 6 (1997), S. 24-29 
    Details
    ISSN: 1615-5939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is a strong need to directly image, noninvasively, atheromatous lesions for early lesion detection, serial assessment of the presence and extent of disease, and treatment monitoring of atherosclerosis. The aim of this study was to investigate the value of polyclonal111Inhuman IgG (111In-HIG) in human carotid artery disease. A comparative study between111In-HIG and125I-LDL uptake in atheromatous lesions was also performed in 12 cholesterol-fed New Zealand white rabbits. Ultrasonographic and scintigraphic findings in 58 patients were compared. HIG was labeled with 500 µCi111Indium by the diethyleneaminepentaacetic anhydride (DTPA). After injection of 10 µCi125I-LDL, the respective entry into aortic segments was evaluated in the animals.111In-HIG accumulation was higher in reendothelialized areas, foam cells, at the edge of lesions, and in hyperlipidemic rabbits. Ultrasound examinations of the carotid arterial wall showed wall thickening in 45 patients and plaques in 44 patients. Scintigraphic imaging of the identical area provided increased uptake in 40 patients and no abnormal uptake of111In-HIG in 18 patients. There was, however, no significant correlation between the radiotracer retention and the ultrasonographic findings or laboratory and clinical parameters. The data provide evidence that the two imaging techniques for early atherosclerotic lesions are visualizing different aspects of atherogenesis: the functional (HIG) on the one side, and the morphological (ultrasonography) on the other side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01616229
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...