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  • 1985-1989  (6)
  • Biomechanical properties  (3)
  • Alzheimer's disease  (2)
  • Angiotensin II  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 67 (1985), S. 167-169 
    ISSN: 1432-0533
    Keywords: Hirano body ; Purkinje cell ; Alzheimer's disease ; Cerebellum ; Senile plaque
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cylindrical forms of Hirano bodies were observed in the perikaryon of a Purkinje cell in a case of Alzheimer's disease. Scattered, typical senile plaques were also seen in the cerebellar cortex.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 67 (1985), S. 296-299 
    ISSN: 1432-0533
    Keywords: Parkinsonism-dementia complex of Guam ; Nucleus raphe dorsalis ; Alzheimer's disease ; Morphometry ; Neurofibrillary tangles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently, morphometric analysis has shown that the nucleus raphe dorsalis, which is presumed to project diffuse serotonergic fibers to the telencephalon, is affected in Alzheimer's disease. A similar study was conducted in this report in two patients with parkinsonism-dementia complex of Guam and a Guamanian control. It demonstrated a significant reduction in the number of large neurons, and the presence of abundant Alzheimer's neurofibrillary tangles in this nucleus.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 80 (1989), S. 59-72 
    ISSN: 1573-4919
    Keywords: heart cells ; aortic cells ; Ca2- current ; K+ current ; slow Na+ current ; Angiotensin II ; calcium blockers ; potassium blockers ; patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The whole-cell voltage clamp technique was used to study the slow inward currents and K+ outward currents in single heart cells of embryonic chick and in rabbit aortic cells. In single heart cells of 3-day-old chick embryo three types of slow inward Na+ currents were found. The kinetics and the pharmacology of the slow INa, were different from those of the slow Ica in older embryos. Two types of slow inward currents were found in aortic single cells of rabbit; angiotensin 11 increased the sustained type and d-cAMP and d-cGMP decreased the slow transient component. Two types of outward K+ currents were found in both aortic and heart cells. Single channel analysis demonstrated the presence of a high single K+ channel conductance in aortic cells. In cardiac and vascular smooth muscles, slow inward currents do share some pharmacological properties, although the regulation of these channels by cyclic nucleotides and several drugs seems to be different.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 25 (1987), S. 631-637 
    ISSN: 1741-0444
    Keywords: Biomechanical impedance ; Biomechanical properties ; Impedance ; Living body structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A physical model for biomechanical impedance has already been proposed. This model is characterised by three impedance spectra: soft, intermediate and hard pattern. An impedance spectrum of the body surface represents mostly the soft pattern, The formative mechanisms of all three patterns have been unsolved until now. Because the physical model is expressed by experimental equations, its theoretical background is not apparent. In the paper a simulating material (simulator) is used, whose tactility is not unlike human skin, and the formative mechanism of biomechanical impedance is revealed through experiments on the simulator under various measuring conditions. The influences of the measuring circumstances, living body structure and physical constants of the body tissues on the experimental equations of the physical model are fully discussed. The formative mechanism of biomechanical impedance which represents the physical model is explained in terms of an equivalent mass, a dynamic equivalent stiffness, a dynamic viscosity and a composite characteristic. The dependence between body parts from which the measurements are taken and soft, intermediate and hard patterns are demonstrated.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 27 (1989), S. 75-81 
    ISSN: 1741-0444
    Keywords: Automatic diagnosis ; Biomechanical properties ; Mechanical mobility ; MT figure ; Periodontium ; Tooth mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Tooth mobility examination is important in planning dental treatment, as it may give an indication of alveolar bone loss and the condition of the periodontal ligament. In clinical dental diagnosis a manual tooth mobility examination is useful. However, its determination of tooth mobility is subjective and depends on the skill and experience of the clinician. The authors have previously reported on a device for measuring the biomechanical properties of human periodontium using an impedance head. Using this device, the mechanical mobility of periodontium can be measured and the mechanical parameters of the periodontal physical model are obtained. Tooth mobility is defined objectively on the basis of discriminant scores of mechanical parameters, and a mobility triangle (MT) figure is drawn as a record for visual interpretation. The paper describes the validation of the mechanical mobility measurements and their interpretation using mobility parameters and a personal computer to produce a mobility triangle figure. The method is compared favourably with clinical mobility measurement. The relationship of the model to underlying pathology is tested by measurements performed on various tooth model systems.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 24 (1986), S. 493-498 
    ISSN: 1741-0444
    Keywords: Biomechanical impedance ; Biomechanical properties ; Impedance ; Modelling of human body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract New experimental modelling of biomechanical impedance is proposed. The parameters which express the impedance characteristics are simply determined by impedance measurement. Audiofrequencies below about 1000 Hz and comparatively lower preloads (below about 6370 kg m−2) are chosen as the research domain. This model, however, can express wide range of body surface impedance not only in soft but also in stiff and intermediate tissues. It will never introduce the impracticably ideal conditions found in the mathematcial models proposed to date. Furthermore the parameters which express the model cannot be determined by impedance measurement alone. The impedance Z(jw) is expressed in two parts: the impedance Z1 (jw) at a higher frequency including a complex mass and the impedance Z2(jw) at a lower frequency including a complex compliance of Cole-Cole’s type. Z1(jw) is the property of body fluid and Z2(jw) is that of a viscoelastic body.
    Type of Medium: Electronic Resource
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