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  • 1985-1989  (2)
  • Anterior pituitary hormone  (1)
  • Prognosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 68 (1985), S. 87-92 
    ISSN: 1432-0533
    Keywords: Pituitary neoplasm ; Anterior pituitary hormone ; Amyloid ; Electron microscopy ; Bromocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accumulation of amyloid in pituitary adenomas was examined in relation to the types of adenoma and the effect of bromocriptine treatment. Amyloid had accumulated in 34 of 48 adenomas (71%). The occurrence in prolactin-secreting adenomas and growth hormone-secreting adenomas was 79%, respectively, while that in non-functioning adenomas was 50%. Treatment with bromocriptine enhanced the occurrence and extent of the amyloid accumulation in prolactin- or growth hormone-secreting adenomas. Electron microscopy revealed the initial appearance of the amyloid fibrils in the smooth endoplasmic reticulum and a possible sequential process of their release from the cells. The presence of secretory granules in vesicles containing amyloid fibrils and their simultaneous release with amyloid fibrils suggested that degradation of secretory granules was involved in the formation of amyloid.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 8 (1986), S. 151-158 
    ISSN: 1435-0130
    Keywords: Cutaneous angiosarcoma ; Prognosis ; Statistical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prognosis of 69 cases of cutaneous angiosarcoma reported in Japan during 1967–1982 was studied statistically. These cases were followed for a minimum of five years. They included 43 males and 26 females. The mean age was 66.8 years. The lesions were confined to the scalp-face region in 60 cases. There was a history of antecendent trauma at the tumor sites in 14 patients and of irradiation in 2 patients. The sites of metastases in order of frequency were the lung, liver and regional lymph nodes. Sixty-four patients died as a result of their tumor. Mean survival was 13.4 months. Five-year survival rate was 6.1%. Only two patients had long-term, disease-free survival. Duration between the onset and the initial visit, and survival period were not correlative. Tumor size was shown to be an important prognostic factor in the scalpface cases. No type of treatment has been particularly effective.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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