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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor (1987)
    Springer
    Psychopharmacology 93 (1987), S. 193-200 
    Details
    ISSN: 1432-2072
    Keywords: Paroxetine ; 5-Hydroxytryptamine uptake ; Radioligand binding ; Antidepressants ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paroxetine was shown to be a potent (K i =1.1 nM) and specific inhibitor of [3H]-5-hydroxytryptamine (5-HT) uptake into rat cortical and hypothalamic synaptosomes in vitro. Lineweaver-Burk kinetic analysis determined that this inhibition was competitive in nature, implying a direct interaction with the 5-HT uptake transporter complex. Oral administration of paroxetine produced a dose-related inhibition of [3H]-5-HT uptake (ED 50=1.9 mg/kg) into rat hypothalamic synaptosomes ex vivo with little effect on [3H]-l-noradrenaline (NA) uptake (ED 50〉30 mg/kg). This selectivity for 5-HT uptake was maintained after oral dosing for 14 days. Paroxetine (ED 50 1–3 mg/kg PO) prevented the 5-HT depleting effect of p-chloroamphetamine (PCA) in rat brain, demonstrating 5-HT uptake blockade in vivo. Radioligand binding techniques in rat brain in vitro showed that paroxetine has little affinity for α1, α2 or β adrenoceptors, dopamine (D2), 5-HT1, 5-HT2 or histamine (H1) receptors at concentrations below 1000 nM. Paroxetine demonstrated weak affinity for muscarinic receptors (K i =89 nM) but was at least 15 fold weaker than amitriptyline (K i =5.1 nM). Paroxetine, therefore, provides a useful pharmacological tool for investigating 5-HT systems and furthermore should be an antidepressant with reduced tricyclic-like side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179933
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  • 2
    Electronic Resource
    Electronic Resource
    Novel reinforced reaction injection molding (RRIM) processing: Computer-controlled multiple-stream RRIM production of interpenetrating polymer networks and polyurethanes (1987)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 27 (1987), S. 1209-1215 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A four-stream computer-controlled reinforced reaction injection molding (RRIM) machine has been developed that attains high accuracy in dispense ratios throughout the injection period. This machine has been used for novel processing of polyurethanes, offering a route to varying product properties either throughout a shot or on a shotto-shot basis. It also has been used for what appears to be the first production on commercial scale RRIM equipment of a polyurethane-acrylic interpenetrating polymer network (IPN) in commercial cycle times of around 2 min.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760271602
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The aminolysis of poly(ethylene terephthalate) (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 33 (1987), S. 2503-2512 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070330719
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    Paper (German National Licenses)
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