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  • 1985-1989  (2)
  • Antihistamine  (1)
  • Tendon  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Feeding induced by blockade of histamine H1-receptor in rat brain (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 216-218 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Antihistamine ; H1-receptor ; feeding elicitation ; α-fluoromethylhistidine ; hypothalamic neuronal histamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by α-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01941710
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Antigen-induced tenosynovitis in hypersensitized rabbits: a model for rheumatoid tenosynovitis (1988)
    Springer
    Rheumatology international 8 (1988), S. 47-53 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Rabbit ; Tenosynovitis ; Antigen ; Tendon ; Rheumatoid arthritis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rabbits were first immunized and later challenged with the same antigen (bovine serum albumin, or ferritin) by injection into the tibialis anterior tendon. Inflammatory changes of the tenosynovium and epitenon included infiltration by neutrophils (early) and mononuclear cells (later) over a 6-week course of tenosynovitis. A pattern of antigen entrapment in the tendon together with immunoglobulin was shown by use of radiolabelled antigen and immunochemical staining. Half-life of antigen in the tissues averaged 5 days over the 6-week period. Changes in the epitenon included cellular necrosis, appearance of phagocytic cells, and disruption of the collagen matrix. Tissues of control animals (challenged without prior immunization) showed minimal changes and significantly less retention of antigen (P〉0.005). The model is relevant to the mechanism of tendon damage associated with antigen-driven chronic inflammation, as may be the case in rheumatoid arthritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00271834
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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