ISSN:
1432-069X
Keywords:
Aromatic retinoid
;
Langerhans cells
;
Ia antigens
;
Ia-reactive cloned T cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of orally administered aromatic retinoid (Ro 10-9359) on murine epidermal Langerhans cells (LC) was studied in vivo and in vitro. Daily administration of retinoid caused a transient increase in LC density, as determined by staining for Ia antigens, during the first few days of treatment and thereafter a continuing decrease that reached a maximum at 2 weeks. In addition, the morphology and location in the epidermis had been altered. When the treatment was continued to 4 weeks, the density of LC returned to normal. The Ia-antigen-presenting function of epidermal cells to an allo-Ia-reactive cloned T cell line was elevated at all stages of retinoid treatment examined. This elevation did not correlate with the density of histochemically stainable Ia+ LC. These findings suggest that orally administered retinoid profoundly alters the functional capacity of Ia+ LC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00413258
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