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  • 1985-1989  (817)
  • Biochemistry and Biotechnology  (538)
  • Computational Chemistry and Molecular Modeling  (224)
  • Magnetic resonance imaging
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of cor triatriatum (1988)
    Springer
    Pediatric cardiology 9 (1988), S. 149-151 
    Details
    ISSN: 1432-1971
    Keywords: Cor triatriatum ; Magnetic resonance imaging ; Phase display
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Magnetic resonance imaging utilizing spin echo sequences was used to demonstrate cor triatriatum in an 18-year-old boy. Phase map images aided the diagnosis by demonstrating the presence of slowly flowing blood in the accessory atrial chamber. Magnetic resonance is an excellent modality for the noninvasive diagnosis of cor triatriatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02080555
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  • 2
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of avascular necrosis of the femoral head (1986)
    Springer
    Skeletal radiology 15 (1986), S. 133-140 
    Details
    ISSN: 1432-2161
    Keywords: Magnetic resonance imaging ; Osteonecrosis ; Bone disease, hip
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigates the role of magnetic resonance imaging (MR) in identifying avascular necrosis (AVN) of the femoral head and in monitoring its therapy. The detection of AVN, particularly in its early stages, is imperative to give therapeutic intervention the best opportunity for successful management. The results of magnetic resonance imaging are compared with those of the standard diagnostic modalities in evaluation of patients with the lesion. Examinations were performed at 0.12 T with a repetition time (TR) of 143 ms and times to echo (TE's) of 10 or 20 ms. This study represents a retrospective review of 90 hips which were examined in 45 consecutive patients. Of these, 52 hips were biopsied as part of treatment. MR was shown to be sensitive in the detection of AVN. Comparison of MR with radionuclide imaging showed comparable sensitivity and specificity. MR was also noted to be sensitive in the detection of early AVN. Preliminary results suggest that MR can monitor treatment of the affected hip, and may even be able to predict patient response to therapy. Although further work is necessary to determine the role of MR in the evaluation of the patient presenting with hip pain, MR is a sensitive method in detecting AVN and in monitoring its course in patients suspected of having the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00350207
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Spectroscopic studies on some phenylethylamine drugs: Molecular orbital calculations (1987)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 31 (1987), S. 855-869 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electronic absorption spectra of some phenylethylamine drugs, namely, d-pseudoepherine, l-pseudoephedrine, l-ephedrine, dl-ephedrine dl-norephedrine, phenylethylamine, methoxyphenamine, and l-noradrenaline were investigated in polar and nonpolar solvents. The observed transitions were interpreted, and the role of σ-π interaction was explored. Molecular orbital calculations were performed on representatives of the above group of compounds, namely, d-pseudoephedrine, l-ephedrine, and l-noradrenaline using the INDO procedures and adopting the best conformer of the molecule. The transition energy, band intensity, and dipole moments were calculated and corresponded satisfactorily with the experimental values.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560310603
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  • 4
    Electronic Resource
    Electronic Resource
    Vanadium containing bromoperoxidase: An example of an oxidoreductase with high operational stability in aqueous and organic mediaSend all correspondence to Ms. G. E. E. van Noppen, F.I.L., Publications Secretary, Laoratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD Amsterdam, The Netherlands. (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 30 (1987), S. 607-610 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The conversion is described of phenolsulphonephtalein (phenol red) to 3,3′,5,5′-tetrabromophenolsulphonephthalein (bromophenol blue) by bromoper-oxidase from the brown alga Ascophyllum nodosum. This reaction provides a convenient assay for the detection of bromoperoxidase activity in vitro. Bromoperoxidase was shown to be stable under turnover conditions for three weeks at room temperature, catalyzing the bromination of phenol red into bromophenol blue. When stored at room temperature in organic sol vents such as acetone, methanol, ethanol [present up to 60% (v/v)], and 1-propanol [40% (v/v)], bromoperoxidase was stable for more than one month. As far as we know this is the first example of an oxidoreductase which displays such great stability. This enhances the applicability of the enzyme in organic synthesis.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260300504
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  • 5
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging and angiography of the brain in embolic left atrial myxoma (1989)
    Springer
    Neuroradiology 31 (1989), S. 137-139 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Cerebral angiography ; Atrial myxoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of left atrial myxoma presenting exclusively with neurological symptoms, studied with magnetic resonance imaging (MRI) combined with cerebral angiography and computed tomography (CT) is reported. Typical angiographic findings suggested the diagnosis of myxoma. MRI showed multiple ischemic lesions disseminated throughout the entire brain, some of which had been clinically asymptomatic. Because of its sensitivity in identifying small cerebral infarcts, MRI should prove in the future to be a first-choice technique in the evaluation of the presence of and extent of cerebral involvement in embolic left atrial myxoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698841
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  • 6
    Electronic Resource
    Electronic Resource
    MRI of intracerebral haematoma at low field (0.15T) using T2 dependent partial saturation sequences (1988)
    Springer
    Neuroradiology 30 (1988), S. 367-371 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Intracerebral haematoma ; Low field MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Results of MRI at 0.15T in twelve successive patients with intracerebral haematoma are reviewed. Using T2 weighted spin echo (SE) and partial saturation (PS without a refocussing 180° pulse) sequences, low intensity areas were seen in eleven of the twelve cases. These included central regions (three cases), a peripheral rim (seven cases) and more diffuse patterns involving the brainstem and cerebral hemispheres (two cases). One case initially displayed a peripheral rim and later a central low intensity region. Central low intensity regions were seen in acute, subacute, and chronic cases. Follow up in five cases displayed an increase in signal within the haematoma in three cases and a decrease in signal intensity in two cases. Low signal intensity areas can be seen within and around intracerebral haematomas imaged with T2 weighted sequences at low field strength.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404099
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  • 7
    Electronic Resource
    Electronic Resource
    The difluoroethylenes: A reconsideration of the “Cis effect” (1986)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 29 (1986), S. 61-72 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ab initio molecular orbital calculations have been carried out on all three isomers of difluoroethylene with geometry optimization. The calculations were done with a “double-zeta” basis set. After correction of the SCF energies for the effect of electron correlation, the 1,1-isomer is shown to be 8 kcal/mole lower in energy than the cis, which is 1 kcal/mole more stable than the trans. As the stabilization of the isomers increases, the distance between the fluorine atoms decreases: trans, 3.57 Å; cis, 2.77 Å; 1,1-isomer 2.20 Å. A simple explanation for these trends is based upon electrostatics and the small size and high electronegativity of the fluorine atom. As the fluorine atoms come closer together, the destabilization due to nuclear repulsions and electron repulsions is offset by the increased stabilizing electrons-nuclei attractions.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560290107
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  • 8
    Electronic Resource
    Electronic Resource
    Electrostatic interactions in the assembly of Escherichia coli aspartate transcarbamylase (1989)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 5 (1989), S. 66-77 
    Details
    ISSN: 0887-3585
    Keywords: subunit interactions ; allosteric regulation ; solvent accessibility ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Although ionizable groups are known to play important roles in the assembly, catalytic, and regulatory mechanisms of Escherichia coli aspartate transcarbamylase, these groups have not been characterized in detail. We report the application of static accessibility modified Tanford-Kirkwood theory to model electrostatic effects associated with the assembly of pair of chains, subunits, and the holoenzyme. All of the interchain interfaces except R1-R6 are stabilized by electrostatic interactions by -2 to -4 kcal-m-1 at pH 8. The pH dependence of the electrostatic component of the free energy of stabilization of intrasubunit contacts (C1-C2 and R1-R6) is qualitatively different from that of intersubunit contacts (C1-C4, C1-R1, and C1-R4). This difference may allow the transmission of information across subunit interfaces to be selectively regulated. Groups whose calculated pK or charge changes as a result of protein-protein interactions have been identified and the results correlated with available information about their function. Both the 240s loop of the c chain and the region near the Zn(II) ion of the r chain contain clusters of ionizable groups whose calculated pK values change by relatively large amounts upon assembly. These pK changes in turn extend to regions of the protein remote from the interface. The possibility that networks of ionizable groups are involved in transmitting information between binding sites is suggested.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340050108
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  • 9
    Electronic Resource
    Electronic Resource
    Crystallization of purified recombinant human interleukin-1β (1988)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 3 (1988), S. 121-129 
    Details
    ISSN: 0887-3585
    Keywords: bioactivity ; SK-hep-1 hepatoma ; interleukin-1 ; recombinant protein ; crystals ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The gene for human interleukin-1β was cloned from SK-hep-1 hepatoma cellular RNA and expressed at high levels in Escherichia coli both as the naturally processed form (rIL-1β) and as a variant with an additional sequence of three amino acids on the N-terminus (rIL-1β+). Expressed protein was purified to homogeneity by a sequence of steps, which included low pH incubation, adsorption and desorption from Procion Red Sepharose, sizing on a Superose 12 fast-performance liquid chromatography (FPLC) column, and anion exchange chromatography on QAE Sepharose. The final step provided a biologically active protein that migrates on twodimensional (2-D) gels as a single spot with a pI of 6.7 ± 0.2 and a molecular mass of 17,500 daltons. Concentrated solutions of rIL-1β have produced crystals by ammonium sulfate precipitation. The crystals are tetragonal, show the symmetry of space group P41 or its enantiomer, have lattice constants of a = 58.46 (1) and c = 77.02 (3) A, and scatter to at least 2 Å resolution. A structure determination based on these crystals is under way.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340030207
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  • 10
    Electronic Resource
    Electronic Resource
    Differences in crystal properties and ligand affinities of an antifluorescyl fab (4-4-20) in two solvent systems (1988)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 3 (1988), S. 155-160 
    Details
    ISSN: 0887-3585
    Keywords: monoclonal antibodies ; high-affinity combining sites ; MPD ; Effects of fluorescein binding ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: An antigen-binding fragment (Fab) from a murine monoclonal antibody (4-4-20) with high affinity for fluorescein was cocrystallized with ligand in polyethylene glycol (PEG) and 2-methl-2,4-pentanediol (MPD) in forms suitable for X-ray analyses. In MPD the affinity of the intact antibody for fluorescein was 300 times lower than the value (3.4 × 1010 M-1) obtained in aqueous buffers. This decreased affinity was manifested by the partial release of bound fluorescein when MPD was added to solutions of liganded Feb during crystallization trials, In PEG, the ligand remained firmly bound to the protein. The liganded Feb crystallized in the monoclinic space group P21 in PEG, with a = 58.6, b = 97.2, c = 44.5 Å and β = 95.2°. In MPD the space group was triclinic P1, with a = 58.3, b = 43.4, c = 42.3 Å, α = 83.9°, β = 87.6°, and γ = 84.5°. X-ray diffraction data were collected for both forms to 2.5-Å resolution. Surprisingly, the triclinic form of the liganed antifluorescyl Feb had the same space group, closely similar cell dimensions, and practically the same orientation in the unit cell as an unliganded Fab (BV04-01) with activity against single-stranded DNA.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340030304
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