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  • 1
    Electronic Resource
    Electronic Resource
    Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 188-192 
    Details
    ISSN: 1432-1335
    Keywords: Experimental nervous system tumor ; Radiation therapy ; Misonidazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rat brain tumor was used as a model to evaluate radiation therapy with and without misonidazole. BD-IX rats were implanted intracerebrally with an ethylnitrosourea-induced glioma. Three series of experiments were performed, with radiation given 14 days after inoculation of the glioma clone. In each series, the following radiation doses were given: 500 rads once, 1,000 rads once; and 1,000 rads twice, every time with or without two different doses of misonidazole. Radiation therapy significantly prolonged survival when compared to the longevity of the control group. The dose of 1,000 rads given twice was highly effective and the life-span of tumor-bearing rats increased from 72% to 121%. Misonidazole plus irradiation negated the prolongation of survival, achieved with radiation therapy alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390355
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of organic solvents on the activity of glucoamylase (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 1172-1177 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Hydrolyses of maltose, maltotriose, and soluble starch catalyzed by glucoamylase (Asp. Niger) were carried out in the aqueous solutions of methanol, ethanol, ethylene glycol, and 1,4-dioxane at 40°C and at the optimum pH in the respective solutions. By the kinetic analysis based on the subsite model, it was shown that the intrinsic rate constant, Kint, was electrostatically affected by the dielectric constant of the hydroorganic solutions. The affinity of the third subsite, A3, which affects the apparent rate constant, K0, was correlated with the ×Gtr's of maltose and amino acid side chains.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260280807
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of fetal hemoglobin in blood stains by high performance liquid chromatography (1989)
    Springer
    International journal of legal medicine 102 (1989), S. 437-444 
    Details
    ISSN: 1437-1596
    Keywords: Fetal hemoglobin, identification in blood stains ; Blood stains, identification of fetal hemoglobin ; Fetales Hämoglobin, in Blutspuren ; Blutspuren, Nachweis von fetalem Hämoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es wurde eine neue Methode zur Identifizierung von fetalem Hämoglobin (Hb F) in Blutspuren mit der umgekehrten Phase-Hochleistungsflüssigkeitschromatographie durchgeführt. Die Unterscheidung zwischen fetalen Blutspuren und denen von Erwachsenen erfolgte aufgrund der Existenz der Spitzen der γ-Ketten von Hb F. In den Chromatogrammen der untersuchten Blutspuren von Erwachsenen traten fast keine γ-Ketten auf. Diese Methode ermöglichte ferner die Bestimmung des Hb F-Wertes mit dem Flächenverhältnis der Globin-Ketten auf den Chromatogrammen. Hb F-Werte der sechs Fälle von Nabelschnurblutspuren auf dem Filterpapier lagen zwischen 81.1% und 91.3%. Die vorliegende Untersuchung zeigt, daß sich der Hb F-Wert für mindestens 12 Wochen nicht ändert. In der Praxis der Rechtsmedizin ist diese Methode im Hinblick auf die Einfachheit, hohe Empfindlichkeit, Schnelligkeit und Zuverlässigkeit sehr wertvoll.
    Notes: Summary A new method for the identification of fetal hemoglobin (Hb F) in blood stains by reverse-phase high performance liquid chromatography is described. Differentiation between fetal and adult blood stains is based on the existence of γ-chain peaks which are characteristic of Hb F. Very few γ chains appeared on chromatograms of all the adult blood stains examined. The level of Hb F could be determined by measuring the total of chromatogram γ-globin chain areas, and expressing it as a percentage of total Hb. Levels in six cord blood stains on filter paper ranged from 81.1% to 91.3% and remained constant for at least 12 weeks. This method is of great value for its simplicity, sensitivity and speed, and most importantly for its reliability in the field of forensic medicine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204074
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Polymerization in submonolayers of styrene monomer adsorbed from its vapor phase (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 26 (1988), S. 1519-1527 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The surface coverage of porous glass (PD = 500 Å) by styrene adsorbed from its vapor (0.1-6 torr) was studied in a vacuum electrobalance. The adsorption isotherm of the monomer was analyzed by the BET method, and a full monolayer coverage was found to form at a relative pressure of 0.11, weighing 6 mg per gram of glass. Polymerization in submonolayers of adsorbed styrene was initiated by thermal decomposition of predeposited BPO and found to continue until all initiator decomposed, sample cooled, or vapor removed, hence allowing a controlled film thickness. The films were extracted in THF and analyzed by computerized GPC. Molecular weights were in the range 18000-69000. These were related to the rates of polymerization by the usual statistical correlations.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1988.090260713
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    Paper (German National Licenses)
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