ISSN:
1432-1041
Keywords:
ramixotidine
;
oesophagitis
;
duodenal ulcer
;
gastro-oesophageal reflux
;
histamine H2-antagonist
;
intragastric pH monitoring
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9–100) vs 97 (27–188) mmol/l. The percentage of time with intraoesophageal pH 〈4 was less than 5% in all but three recordings, with a maximum value of 12%, and it was not significantly different after the two treatments.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558510
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