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  • 1
    Electronic Resource
    Electronic Resource
    Intragastric and intraoesophagel pH monitoring in duodenal ulcer patients: effect of the new histamine H2-receptor antagonist ramixotidine (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: ramixotidine ; oesophagitis ; duodenal ulcer ; gastro-oesophageal reflux ; histamine H2-antagonist ; intragastric pH monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9–100) vs 97 (27–188) mmol/l. The percentage of time with intraoesophageal pH 〈4 was less than 5% in all but three recordings, with a maximum value of 12%, and it was not significantly different after the two treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558510
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Orocecal transit delay in obese patients (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 509-512 
    Details
    ISSN: 1573-2568
    Keywords: opioids ; naloxone ; gastrointestinal motility ; breath test ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Orocecal transit time was assessed with lactulose hydrogen breath test in 12 obese patients during intravenous infusion of placebo or naloxone 40 μg/kg/hr given in randomized order and in double-blind conditions. Transit time was also evaluated in 22 healthy controls. Orocecal transit was significantly (P〈0.01) longer in the obese patients during placebo treatment (median 130, range 100–200 min) than in the healthy controls (median 75, range 40–170 min). Compared with placebo, transit time in the obese subjects was delayed (P〈0.05) during naloxone treatment (median 150, range 100–230 min).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536325
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Repeatability of lactulose hydrogen breath test in subjects with normal or prolonged orocecal transit (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 1525-1527 
    Details
    ISSN: 1573-2568
    Keywords: breath test ; gastrointestinal motility ; constipation ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The within-subject repeatability of orocecal transit assessed with lactulose hydrogen breath test was evaluated in 15 healthy volunteers and 16 constipated or obese patients. The test was repeated twice in each subject. Mean (sd) transit time was 105 (63) and 103 (60) min in the first and second series of tests, respectively, showing that the first measurement did not affect the second. The within-subject repeatability of the test was related to the length of transit, the scatter of the differences between the first and second test being greater with the increase of the mean gastrointestinal transit time. The 95% coefficient of repeatability was 84 min for all measurements and 30 and 118 min, respectively, for transit times under and over 100 min. The lowest reproducibility of the test was found in constipated patients with prolonged orocecal transit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535941
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Lactose malabsorption and intolerance in Italians (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 1313-1316 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lactose malabsorption was assessed by the hydrogen breath test in 40 Italian patients with irritable bowel syndrome and 42 controls without abdominal disturbances. Sixty-five percent of patients were “low milk consumers” (0–250 ml milk per day) compared with 38% of controls (P〈0.02). Lactose loads of 25 and 50 g caused malabsorption in 82.5 and 87.5% patients and in 55 and 62% controls, respectively (patients vs controlsP〈0.02). Malabsorption was more frequent in the “low milk consumers” group (P〈0.05). During a four-month lactose-free diet as the only treatment 7.5% of patients became symptomfree (and remained so for a further eight-month diet), 52.5% improved, and 40% showed no change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299809
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Oral naloxone antagonizes loperamide-induced delay of orocecal transit (1987)
    Springer
    Digestive diseases and sciences 32 (1987), S. 829-832 
    Details
    ISSN: 1573-2568
    Keywords: naloxone ; loperamide ; orocecal transit ; hydrogen breath test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Orocecal transit time was determined by the lactulose hydrogen breath test in nine healthy volunteers after administration of placebo, loperamide (16 mgper os), and loperamide (16 mgper os) followed by oral naloxone at doses of 16 and 32 mg. The four tests were performed in double-blind conditions and in random sequences. Transit time (mean,sd) after loperamide (128.8 min, 32.9) was significantly increased (P〈0.05) compared with placebo (85.5 min, 35.7), loperamide followed by naloxone 16 mg (88.8 min, 46.2), and loperamide followed by naloxone 32 mg (84.4 min, 40.6). These results show that the peripheral opioid agonist loperamide delays orocecal transit in healthy subjects and that naloxoneper os at adequate doses antagonizes this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296704
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    Paper (German National Licenses)
    Fulltext
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