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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic studies of high-dose metoclopramide with and without forced diuresis (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 572-574 
    Details
    ISSN: 1432-1440
    Keywords: Metoclopramide ; High dose Metoclopramide ; Pharmacokinetics ; Antiemetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of high-dose metoclopramide (10 mg/kg body wt. in five infusions of 2 mg/kg body wt. each) was studied in 11 patients (5 females, 6 males) in two groups: group A with and group B (consisting of five patients) without forced diuresis. When the drug was infused, forced diuresis had no influence on the pharmacokinetics of metoclopramide (serum level after the 1st infusion was 851±361 ng/ml in group A versus 840±348 ng/ml in group B; after the 5th infusion it was 2,005±588 ng/ml in group A versus 2,463±1,350 ng/ml in group B). There were significant differences in the 24-h serum levels (582±308 ng/ml in group A versus 379±170 ng/ml in group B;P〈0.05) and in the elimination half life (8.5±2.6 h in group A versus 6.1±1.1 h in group B;P〈0.05). The results demonstrate that the dosage regimen originally suggested by Gralla for cytostatic drugs, with forced diuresis for high-dose metoclopramide therapy, may also be applied, with no dosage reduction, with to other cytostatic drugs which do not require forced diuresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733203
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  • 2
    Electronic Resource
    Electronic Resource
    Activity of phagocytic granulocytes in patients with prostatic cancer (1986)
    Springer
    Urological research 14 (1986), S. 327-330 
    Details
    ISSN: 1434-0879
    Keywords: BCG vaccination ; External radiotherapy ; Chemilumenescence ; Polymorphonuclear neutrophils ; Prostatic carcinoma ; Estrogen therapy ; Estramustine therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chemilumenescence (CL) occurs due to the phagocytosis of bacteria and of tumor cells by polymorphonuclear neutrophils (PMN). Levels of CL were measured in patients with prostatic cancer and from normal subjects. Patients with advanced disease (stage C, D) showed no elevated CL levels as compared to healthy individuals or patients with minimal disease (stage A, B). Following external radiation therapy in patients with stage A-C prostatic carcinoma high levels of CL were recorded. Estrogen medication also resulted in increased CL levels, while estramustine did not affect phagocytic activity. Intradermal BCG vaccination caused increased PMN activity. Progressive prostatic cancer in hormone treated patients was associated with increased CL as compared to patients with stable or regressive disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262385
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  • 3
    Electronic Resource
    Electronic Resource
    The incidence of multiple meningiomas—Do solitary meningiomas exist? (1988)
    Springer
    Acta neurochirurgica 90 (1988), S. 15-22 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial tumours ; solitary tumours ; multiple tumours ; multicentricity ; meningiomas ; computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the advent of computed tomography (CT) the recognition of the occurrence of multiple intracranial meningiomas (MIM) in the same individual has been on the increase. In our material the incidence of MIM at first assessment of CT films was 20%, with distant multiplicity prevailing over the regional one. This incidence will probably change in the course of time as MIM develop not only concurrently but also consecutively. On the other hand our surgical macroscopic incidence of regional multiplicity alone was 49%. The discrepancy between the CT and surgical findings prompted us to reevaluate the CT studies of 100 consecutive patients. This reevaluation demonstrated: 1. in two cases, small meningiomas were overlooked at first assessment; 2. nineteen cases of solitary globoid meningiomas seemed to be the consequence of the coalescence of adjacent smaller masses. Thus, the CT incidence of MIM increased to 40%, with regional multiplicity prevailing over the distant one. The authors think that the aforesaid findings question the very existence of solitary meningiomas as a pathological entity. They would be the end product of a coalescence of multiple adjacent smaller growths. Accordingly, a more aggressive surgical approach is suggested to include the resection of a generous fringe of dura mater around the main tumour. As this is not always possible, or too risky, a comprehensive complement to surgery like radiotherapy could be given a reasonable randomized trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541261
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  • 4
    Electronic Resource
    Electronic Resource
    Percutaneous endoluminal angioplasty of post endarterectomy carotid stenoses (1987)
    Springer
    Neuroradiology 29 (1987), S. 186-189 
    Details
    ISSN: 1432-1920
    Keywords: Angioblasty ; Carotid artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Percutaneous transluminal angioplasty of the carotid artery was performed in four patients with recurrent stenosis following endarterectomy. Balloon catheter dilatation was successful in 3 of the 4 lesions. Post dilation angiography demonstrated an increase in luminal diameter: there were no neurological complications with the procedure. PTA appears to be an effective method of treating recurrent stenosis following carotid endarterectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327547
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  • 5
    Electronic Resource
    Electronic Resource
    Bioavailability of disopyramide in normal volunteers using unbound concentration (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 625-629 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; bioavailability ; saturable binding ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of disopyramide were determined in 10 healthy volunteers after a 300 mg oral dose and again after a 2mg/kg i.v. dose. The unbound clearance was 599 ml/min and the unbound renal clearance 310 ml/min. The terminal elimination rate constant of unbound drug was 0.180 h−1 after the i.v. dose and 0.203 h−1 after the oral dose. The absorption rate constant was 0.53−1 and the maximum peak concentration occurred after 3.2 h. The bioavailability was 0.809 using the area under the unbound plasma concentration time curve. Although a saturable plasma protein binding was found in all subjects the bioavailability using the total concentration, in contrast to theoretical expectations, showed the same value (0.813) as the unbound concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02456000
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  • 6
    Electronic Resource
    Electronic Resource
    Does alpha1-acid glycoprotein reduce the unbound metabolic clearance of disopyramide in patients with renal impairment? (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 313-317 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; alpha1-acid glycoprotein ; renal dysfunction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of disopyramide was studied in 15 patients with renal dysfunction (4 with pyelonephritis, 7 with glomerular nephritis and 4 with interstitial nephritis). The elimination rate constant of unbound disopyramide was 0.094 h−1 and CLu/f (unbound clearance divided by bioavailability) was 245 ml/min. Both the unbound renal clearance (CLR) and CLu/f were highly correlated with the creatinine clearance (CLCR). The apparent unbound metabolic clearance in the patients was approximately two-fold lower than that previously reported in normal subjects. The estimated unbound metabolic clearance in the renal dysfunction patients showed a significant negative correlation with the α1-acid glycoprotein (AAG) concentration and only a weak, non-significant correlation with CLCR. As AAG in the renal dysfunction subjects was increased in comparison with normal values, it is possible that AAG is a factor in the decrease in the apparent unbound metabolic clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558271
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of flecainide in patients with mild and moderate renal failure compared with patients with normal renal function (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 711-714 
    Details
    ISSN: 1432-1041
    Keywords: flecainide ; pharmacokinetics ; moderate renal failure ; variability of elimination half-time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of flecainide after the oral administration of 100 mg to 8 patients without renal impairment and 8 patients with mild to moderate renal failure. Both groups gave comparable results with respect to the peak plasma concentrations and the time to peak. There was a significant correlation between renal flecainide clearance and endogenous creatinine clearance. The elimination half-time in the patients with impaired renal function was significantly longer (19.9, SD 9.9 h) than that in the patients with normal renal function (11.5, SD 4.2 h), but the variability in the elimination half-time in renal failure could not be explained on the basis of the available results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541300
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of tocainide in patients with severe renal failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 665-670 
    Details
    ISSN: 1432-1041
    Keywords: tocainide ; renal failure ; pharmacokinetics ; oral dosing ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels of tocainide have been followed after oral administration of 600 mg p.o. to 20 patients with renal failure due to various causes, and to 8 healthy controls. The peak plasma concentrations in the patients with pyelonephritis (3.80 µg/ml) and interstitial nephritis (3.74 µg/ml) but not in those with glomerulonephritis (3.17 µg/ml) differed from that in healthy volunteers (3.24 µg/ml). The renal clearance of tocainide was well correlated with the endogenous creatinine clearance and was dependent on urine pH. No difference in renal clearance was observed between the patients groups. It is suggested that the changes in plasma levels are a consequence of decreased renal clearance. Creatinine clearance was shown to be a poor estimator of tocainide clearance, which suggests that extrarenal clearance plays an important role in the handling of the drug in the body. The findings are used to suggest a safe dosage regimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607912
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  • 9
    Electronic Resource
    Electronic Resource
    Anreicherung von Gold- und Silberspuren durch Flotation wäßriger Lösungen mit nachfolgender flammenatomabsorptionsspektrometrischer Bestimmung (FAAS) (1985)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 322 (1985), S. 17-19 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Gold- und Silberionen können in wäßriger Lösung mittels Zinnoxidhydrat gefällt und nach Zugabe von 2-Phenylethylenphosphonsäure sowie Reagentien zur Schaumbildung durch Flotation leicht abgetrennt werden. Nach der Anreicherung kann durch Flammenabsorptionsspektrometrie eine quantitative Gehaltsbestimmung durchgeführt werden. Extraktion des Analyten mit i-Amylalkohol schaltet den Störeinfluß von Schwermetallionen bei der Goldbestimmung aus. Nach Flotation aus 1 l Lösung können Gehalte von ng · ml−1 ausreichend sicher und richtig bestimmt werden.
    Notes: Summary Gold and silver ions can be precipitated in aqueous solutions by means of stannic hydroxide and after addition of 2-phenylethylene phosphonic acid and foaming agents be easily separated by flotation. After enrichment a quantitative analysis can be carried out by flame atomic-absorption spectroscopy. The disturbing influence of heavy metal ions in gold assaying is eliminated by the extraction of the substance to be analyzed by means of i-amyl alcohol. After flotation of 1 l solution contents of ng · ml−1 can be analyzed with sufficient accuracy and precision.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493033
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  • 10
    Electronic Resource
    Electronic Resource
    75. Proktocolektomie mit direkter Ileoanostomie und vorgeschalteter Dünndarmtasche (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 429-432 
    Details
    ISSN: 1435-2451
    Keywords: Restorative proctocolectomy ; Direct ileoanal pouch anastomosis ; Indications ; Proktocolektomie ; Direkte pouchoanale Anastomose ; Indikationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Colon- und Rectumentfernung mit direkter pouchoanaler Anastomose ohne Erhalt eines rectalen Muskelmantels erweist sich bei 26 Patienten als gute Methode zur sicheren und dauerhaften Sanierung der Colitis ulcerosa und der Adenomatosis coli et recti, über auch zur Eliminierung des manifesten Carcinoms. Ihre Vorteile sind vor allen Dingen die gleichzeitige Aufrechterhaltung einer regelrechten Kontinenzfunktion bei niedrigem Operationsrisiko und geringer postoperativer Komplikationsneigung. Kontraindikationen zu dieser operativen Vorgehensweise ergeben sich nach wie vor bei Vorliegen eines Morbus Crohn. Einschränkungen erfährt die Methode darüber hinaus bei primär gestörter Schliessmuskelfunktion.
    Notes: Summary Our experiences with 26 patients show that total proctocolectomy with direct ileoanal pouch anastomosis and without maintenance of the rectal muscle cuff proves to be an excellent method for sucure and lasting treatment of UC and ACR as well as of manifest cancer. The advantage of this method is the maintenance of normal continence function at a lower operative risk and few postoperative complications. Contraindication for this operative approach is still Crohn' disease. Furthermore the indication is limited by primary dysfunction of the anal sphincter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297859
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