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  • 1985-1989  (2)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    The Serum Antibody Response Distributed in Subclasses and Isotypes after Intranasal and Subcutaneous Immunization with Influenza Virus Immunostimulating Complexes (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 27 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunostimulating complexes (iscoms) were prepared from influenza virus glycoproteins (A/PR8(H1N1)). Mice were inoculated with iscoms by local (oral or intranasal) as well ashy subcutaneous administration. It was shown that one subcutaneous or intranasal inoculation induced serum antibody responses of similar magnitude. The intranasal administration, however, induced somewhat higher IgA and IgM titres than that induced subcutaneous. After a second intranasal or subcutaneous inoculation a prominent increase of the IgG isotypes was found. The secondary IgA and IgM responses were of similar magnitude as those induced alter the primary inoculation. The antibody responses induced were evenly distributed within the IgG isotypes, although the highest titres recorded were of the IgG1 and IgG2 isotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02343.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inflammatory response and antigen localization following immunization with influenza virus ISCOMs (1989)
    Springer
    Inflammation 13 (1989), S. 641-649 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inflammatory response, antigen retention, and antigen localization was studied in mice after immunization with influenza virus glycoproteins presented in two physically defined forms-micelles and ISCOMS (immunostimulating complexes). Two hours after intraperitoneal injection, the proportion of polymorphonuclear leukocytes (PMNs) in peritoneal lavage cells increased from less than 1% to 82% in ISCOM-treated mice and from 〈1% to 41% of the total cell count in micelle-treated mice. For both treatment groups, the proportion of PMNs returned to around zero 24 h postimmunization. Total recovery of radioactive antigen was significantly greater (P〈0.05) in ISCOM-treated than in micelle-treated mice at one, two, and eight days postinjection. At all times tested, animals given ISCOMs had significantly more radioactive antigen in their spleens than animals given micelles. By electron microscopy ISCOMs were found to attach externally to the plasma membrane or within phagosomes of macrophages in close association with the membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00914308
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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